Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1296275 Clostridium difficile 630, complete genome

Start: 1296275, End: 1300306, Length: 4032

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012781:700226:7344437344437354921050Eubacterium rectale ATCC 33656, complete genomehypothetical protein8e-118426
NC_012781:2552723:2563267256326725643161050Eubacterium rectale ATCC 33656, complete genomehypothetical protein8e-118426
NC_018867:10238:3771937719395181800Dehalobacter sp. CF chromosome, complete genomeDNA repair protein RadC1e-59232
NC_014828:1905479:190547919054791906192714Ethanoligenens harbinense YUAN-3 chromosome, complete genomeAntirestriction ArdA family protein3e-39165
NC_017167:1648913:1726187172618717277881602Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1hypothetical protein1e-37159
NC_016630:434500:4368074368074382401434Filifactor alocis ATCC 35896 chromosome, complete genomeantirestriction protein (ArdA)7e-37157
NC_017167:2298962:2333988233398823355891602Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1hypothetical protein2e-36155
NC_015520:2612767:261451626145162615409894Mahella australiensis 50-1 BON chromosome, complete genomehypothetical protein2e-33145
NC_013205:576583:5942285942285955051278Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,4e-33144
NC_013206:21288:450524505245900849Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446hypothetical protein1e-32143
NC_015943:72000:884688846889430963Haloarcula hispanica ATCC 33960 chromosome chromosome II, completeLtrC-like protein6e-32140
NC_019962:1750497:182793618279361828874939Natrinema pellirubrum DSM 15624, complete genomehypothetical protein9e-32140
NC_015977:2966971:296697129669712967684714Roseburia hominis A2-183 chromosome, complete genomehypothetical protein1e-31139
NC_009706:238160:260396260396261100705Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein4e-31138
NC_011837:238160:260396260396261100705Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-31138
NC_019962:1909103:194084019408401941775936Natrinema pellirubrum DSM 15624, complete genomehypothetical protein2e-30135
NC_012781:2552723:256253925625392563252714Eubacterium rectale ATCC 33656, complete genomehypothetical protein3e-30135
NC_009455:173374:2016662016662032101545Dehalococcoides sp. BAV1 chromosome, complete genomehypothetical protein4e-30134
NC_004368:1160535:1170113117011311733643252Streptococcus agalactiae NEM316, complete genomehypothetical protein1e-29132
NC_013890:191616:1947901947901963341545Dehalococcoides sp. GT chromosome, complete genomeprotein of unknown function DUF1922e-29132
NC_013966:107526:107526107526108455930Haloferax volcanii DS2 plasmid pHV4, complete sequenceLtrC-like protein1e-26122
NC_012030:141719:164071164071165000930Halorubrum lacusprofundi ATCC 49239 plasmid pHLAC01, completeLtrC-like protein4e-26121
NC_011206:200000:2199482199482250985151Acidithiobacillus ferrooxidans ATCC 53993, complete genomedomain of unknown function DUF17387e-25117
NC_011206:1264639:1264639126463912690124374Acidithiobacillus ferrooxidans ATCC 53993, complete genomedomain of unknown function DUF17383e-24115
NC_012483:3672768:369465936946593695630972Acidobacterium capsulatum ATCC 51196, complete genomehypothetical protein2e-23112
NC_012483:1408500:143994514399451440925981Acidobacterium capsulatum ATCC 51196, complete genomehypothetical protein3e-23111
NC_020418:116500:147805147805148389585Morganella morganii subsp. morganii KT, complete genomehypothetical protein3e-23111
NC_016631:4113794:414247041424704143366897Granulicella mallensis MP5ACTX8 chromosome, complete genomehypothetical protein7e-21103
NC_009339:252174:2664652664652675081044Mycobacterium gilvum PYR-GCK plasmid pMFLV01, complete sequenceLtrC-like protein8e-21103
NC_007323:81837:9132891328930971770Bacillus anthracis str. 'Ames Ancestor' plasmid pXO2, completehypothetical protein8e-20100
NC_010170:3944228:398048739804873981287801Bordetella petrii, complete genomehypothetical protein3e-1999
NC_009974:53865:722067220673129924Herpetosiphon aurantiacus ATCC 23779 plasmid pHAU02, completehypothetical protein5e-1997.8
NC_014394:993465:101246010124601013368909Gallionella capsiferriformans ES-2 chromosome, complete genomehypothetical protein4e-1481.6
NC_012781:3315614:3323853332385333266092757Eubacterium rectale ATCC 33656, complete genomehypothetical protein2e-1379.3
NC_013132:3959258:398207039820703982606537Chitinophaga pinensis DSM 2588, complete genomedomain of unknown function DUF17386e-1377.8
NC_015573:1573621:158995515899551590803849Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomehypothetical protein2e-1275.9
NC_016943:4692561:4712503471250347145932091Blastococcus saxobsidens DD2, complete genomeintegrase family protein (modular protein)5e-1274.7
NC_009615:4693164:4701132470113247022741143Parabacteroides distasonis ATCC 8503 chromosome, complete genomehypothetical protein1e-1173.6
NC_009614:915605:9229569229569240831128Bacteroides vulgatus ATCC 8482 chromosome, complete genomehypothetical protein3e-1172
NC_007644:362000:362392362392363306915Moorella thermoacetica ATCC 39073, complete genomehypothetical protein4e-1068.2
NC_004663:3216518:322582132258213226372552Bacteroides thetaiotaomicron VPI-5482, complete genomehypothetical protein6e-1067.4
NC_019903:1312843:132502313250231325583561Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,hypothetical protein1e-0966.6
NC_019903:1345585:136057413605741361140567Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,hypothetical protein7e-0964.3
NC_018866:1402259:140654914065491407106558Dehalobacter sp. DCA chromosome, complete genomehypothetical protein7e-0963.9
NC_015144:237467:260157260157261095939Weeksella virosa DSM 16922 chromosome, complete genomehypothetical protein2e-0862.4
NC_019903:1745849:175763117576311758191561Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,hypothetical protein2e-0862.4
NC_014376:3064787:307047730704773071034558Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein3e-0862
NC_013216:1442044:144439214443921445273882Desulfotomaculum acetoxidans DSM 771, complete genomehypothetical protein3e-0861.6
NC_010337:565730:587146587146587706561Heliobacterium modesticaldum Ice1, complete genomehypothetical protein1e-0760.1
NC_013768:1830419:184788718478871848435549Listeria monocytogenes 08-5923, complete genomehypothetical protein3e-0758.5
NC_013766:1859634:188115618811561881704549Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein3e-0758.5
NC_009253:897684:909505909505910341837Desulfotomaculum reducens MI-1 chromosome, complete genomehypothetical protein5e-0758.2
NC_021184:3571014:357914235791423579702561Desulfotomaculum gibsoniae DSM 7213, complete genomehypothetical protein1e-0657
NC_007907:3872805:3890214389021438912451032Desulfitobacterium hafniense Y51, complete genomehypothetical protein9e-0757
NC_015954:1222776:123057712305771230828252Halophilic archaeon DL31 chromosome, complete genomeLtrC-like protein2e-0655.8
NC_018866:1328623:133148713314871332353867Dehalobacter sp. DCA chromosome, complete genomehypothetical protein7e-0654.3
NC_018867:1407163:141002714100271410893867Dehalobacter sp. CF chromosome, complete genomehypothetical protein7e-0654.3
NC_018866:1328623:1334051133405113352231173Dehalobacter sp. DCA chromosome, complete genomehypothetical protein7e-0654.3
NC_018867:1407163:1412591141259114137631173Dehalobacter sp. CF chromosome, complete genomehypothetical protein7e-0654.3