Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1293051 Clostridium difficile 630, complete genome

Start: 1293051, End: 1294400, Length: 1350

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014828:501342:5029105029105043131404Ethanoligenens harbinense YUAN-3 chromosome, complete genomeRelaxase/mobilization nuclease family protein1e-95350
NC_009089:478328:5056165056165069471332Clostridium difficile 630, complete genomeputative mobilization protein9e-87321
NC_012471:1197534:1234253123425312356261374Streptococcus equi subsp. equi 4047, complete genomeconjugative transposon mobilization protein4e-86318
NC_016630:1247251:1272247127224712735781332Filifactor alocis ATCC 35896 chromosome, complete genomerelaxase4e-85315
NC_009089:2150062:2170086217008621714171332Clostridium difficile 630, complete genomeputative conjugative transposon mobilization protein3e-84312
NC_016630:434500:4346024346024359991398Filifactor alocis ATCC 35896 chromosome, complete genomerelaxase/Mobilization nuclease domain protein8e-83308
NC_013895:1332832:1350229135022913515601332Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completerelaxase/mobilization nuclease domain protein9e-83307
NC_012470:1390285:1415776141577614171071332Streptococcus equi subsp. zooepidemicus, complete genomerelaxase/mobilisation protein1e-81303
NC_013316:2033906:2112394211239421137251332Clostridium difficile R20291, complete genomeputative conjugative transposon mobilization protein1e-80300
NC_015977:3215770:3263524326352432649271404Roseburia hominis A2-183 chromosome, complete genomehypothetical protein4e-80298
NC_014828:2038692:2050820205082020522261407Ethanoligenens harbinense YUAN-3 chromosome, complete genomeRelaxase/mobilization nuclease family protein2e-79296
NC_015278:176508:1828351828351841661332Aerococcus urinae ACS-120-V-Col10a chromosome, complete genomerelaxase/mobilization nuclease domain protein1e-79296
NC_004668:2198027:2220066222006622214781413Enterococcus faecalis V583, complete genomehypothetical protein4e-78292
NC_016048:2873669:2883806288380628852031398Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-69263
NC_018867:10238:4887748877500611185Dehalobacter sp. CF chromosome, complete genomehypothetical protein1e-67257
NC_014828:637523:6652706652706666761407Ethanoligenens harbinense YUAN-3 chromosome, complete genome2e-63243
NC_011837:238160:2444542444542458841431Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-62240
NC_009706:238160:2444542444542458601407Clostridium kluyveri DSM 555 chromosome, complete genomeRLX-like protein2e-62239
NC_012781:700226:7072357072357086501416Eubacterium rectale ATCC 33656, complete genomehypothetical protein6e-61235
NC_018867:121512:1223021223021236871386Dehalobacter sp. CF chromosome, complete genomeRelaxase2e-45184
NC_016048:2907702:2966363296636329674271065Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein8e-42171
NC_006087:765081:7713317713317729051575Leifsonia xyli subsp. xyli str. CTCB07, complete genomemobilization protein1e-40167
NC_014246:57021:7816878168796281461Mobiluncus curtisii ATCC 43063 chromosome, complete genomeputative mobilization protein2e-37157
NC_015385:2050648:2061439206143920631061668Treponema succinifaciens DSM 2489 chromosome, complete genomeRelaxase/mobilization nuclease family protein1e-33144
NC_015977:3424178:3512461351246135139091449Roseburia hominis A2-183 chromosome, complete genomehypothetical protein1e-32140
NC_008023:1070986:1085863108586310873381476Streptococcus pyogenes MGAS2096, complete genomeRelaxase4e-29129
NC_015214:1853106:1864211186421118654191209Lactobacillus acidophilus 30SC chromosome, complete genomehypothetical protein2e-28127
NC_016077:702000:7086737086737101091437Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein6e-25115
NC_014638:183115:2168002168002186921893Bifidobacterium bifidum PRL2010 chromosome, complete genomerelaxase3e-22106
NC_006663:1:2288322883238991017Staphylococcus epidermidis RP62A plasmid pSERP, complete sequencerlx protein, putative4e-21102
NC_016749:1914481:1944707194470719463351629Streptococcus macedonicus ACA-DC 198, complete genomehypothetical protein1e-20101
NC_014616:169311:184787184787185671885Bifidobacterium bifidum S17 chromosome, complete genomeRelaxase3e-20100
NC_004368:1160535:1166876116687611685251650Streptococcus agalactiae NEM316, complete genomehypothetical protein2e-1997.4
NC_015052:1313311:1336225133622513378561632Bifidobacterium longum subsp. infantis 157F, complete genomehypothetical protein5e-1995.9
NC_014824:263491:274436274436275094659Ruminococcus albus 7 plasmid pRUMAL01, complete sequence2e-1893.6
NC_009012:3823879:3841627384162738430181392Clostridium thermocellum ATCC 27405, complete genomeRelaxase/mobilization nuclease domain containing protein1e-1791.3
NC_009442:867625:8844608844608863251866Streptococcus suis 05ZYH33 chromosome, complete genomechromosome segregation ATPase9e-1375.1
NC_014624:1768226:1785877178587717875201644Eubacterium limosum KIST612 chromosome, complete genomerelaxase/mobilization nuclease family protein1e-1067.8
NC_015275:3407358:3431721343172134328541134Clostridium lentocellum DSM 5427 chromosome, complete genomeRelaxase/mobilization nuclease family protein2e-1067.4
NC_015737:831792:8321218321218332541134Clostridium sp. SY8519, complete genomehypothetical protein7e-1065.5
NC_015977:3424178:3466782346678234680711290Roseburia hominis A2-183 chromosome, complete genomehypothetical protein2e-0653.9
NC_012470:1946968:195423519542351954627393Streptococcus equi subsp. zooepidemicus, complete genome4e-0653.1
NC_012891:1277966:1292370129237012938541485Streptococcus dysgalactiae subsp. equisimilis GGS_124 chromosome 1,hypothetical protein8e-0652