Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1292159 Clostridium difficile 630, complete genome

Start: 1292159, End: 1292512, Length: 354

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009089:1283000:12830001283000131493031931Clostridium difficile 630, complete genome1e-65247
NC_009089:581655:602302602302602655354Clostridium difficile 630, complete genomeputative conjugative transposon regulatory protein1e-21101
NC_009089:3889811:389417038941703894526357Clostridium difficile 630, complete genomeputative transposon-related DNA-binding protein3e-21100
NC_016630:1247251:125037812503781250731354Filifactor alocis ATCC 35896 chromosome, complete genometranscriptional regulator9e-2198.6
NC_013895:1332832:135496313549631355316354Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completeDNA-binding protein8e-2095.9
NC_021175:1597613:160681316068131607166354Streptococcus oligofermentans AS 1.3089, complete genometranscriptional regulator8e-2095.9
NC_017347:424500:426336426336426689354Staphylococcus aureus subsp. aureus T0131 chromosome, completeTranscriptional regulator, Tn9168e-2095.5
NC_017341:428500:429998429998430351354Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,putative transcriptional regulator8e-2095.5
NC_002758:434462:439169439169439522354Staphylococcus aureus subsp. aureus Mu50, complete genomeputative transcriptional regulator8e-2095.5
NC_008023:1070986:107307110730711073430360Streptococcus pyogenes MGAS2096, complete genomeTranscriptional regulator, MerR family6e-1682.8
NC_012781:700226:706700706700707065366Eubacterium rectale ATCC 33656, complete genomehypothetical protein3e-1373.9
NC_016627:4159406:418127141812714181597327Clostridium clariflavum DSM 19732 chromosome, complete genomeHelix-turn-helix protein6e-0959.7
NC_016048:3063888:309500030950003095257258Oscillibacter valericigenes Sjm18-20, complete genomeputative Xre family DNA-binding protein1e-0755.1
NC_015977:3324000:332771733277173328085369Roseburia hominis A2-183 chromosome, complete genomehypothetical protein3e-0753.9
NC_011837:3814000:383833038383303838653324Clostridium kluyveri NBRC 12016, complete genomehypothetical protein9e-0752.4
NC_009706:3882500:390682739068273907150324Clostridium kluyveri DSM 555 chromosome, complete genometranscriptional regulator9e-0752.4
NC_016048:4163225:419888941988894199212324Oscillibacter valericigenes Sjm18-20, complete genomeputative Xre family DNA-binding protein1e-0652
NC_016048:2873669:289392928939292894270342Oscillibacter valericigenes Sjm18-20, complete genomeputative Xre family DNA-binding protein6e-0649.7