Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1291809 Clostridium difficile 630, complete genome

Start: 1291809, End: 1292030, Length: 222

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009089:370555:387748387748387936189Clostridium difficile 630, complete genomehypothetical protein7e-23105
NC_013316:371953:389145389145389333189Clostridium difficile R20291, complete genomehypothetical protein3e-22103
NC_014376:3399366:341116734111673411352186Clostridium saccharolyticum WM1 chromosome, complete genometransposase-like protein3e-1683.6
NC_012781:700226:706236706236706424189Eubacterium rectale ATCC 33656, complete genomehypothetical protein9e-1682
NC_009706:56000:669406694067119180Clostridium kluyveri DSM 555 chromosome, complete genometransposase2e-1477.8
NC_018870:757416:788163788163788390228Thermacetogenium phaeum DSM 12270 chromosome, complete genomeputative transposase2e-1374.7
NC_016048:2907702:292234829223482922524177Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein3e-1373.9
NC_014393:4775452:483404548340454834224180Clostridium cellulovorans 743B chromosome, complete genometransposase3e-1373.6
NC_010337:616304:624990624990625169180Heliobacterium modesticaldum Ice1, complete genomehypothetical protein9e-1372.4
NC_018866:1328623:134617413461741346347174Dehalobacter sp. DCA chromosome, complete genomehypothetical protein1e-1272
NC_009706:3882500:390335439033543903533180Clostridium kluyveri DSM 555 chromosome, complete genometransposase2e-1270.9
NC_011837:3814000:382144938214493821694246Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-1270.1
NC_014410:800500:800584800584800772189Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,hypothetical protein5e-1269.7
NC_019903:1312843:133614213361421337074933Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,DNA-binding domain-containing protein2e-1168.2
NC_016791:3891272:389633838963383896538201Clostridium sp. BNL1100 chromosome, complete genomehypothetical protein2e-1167.8
NC_014376:3399366:341842234184223418604183Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein2e-1167.8
NC_011830:4187362:419974841997484199945198Desulfitobacterium hafniense DCB-2, complete genomehypothetical protein2e-1167.4
NC_021184:1484352:149057514905751490781207Desulfotomaculum gibsoniae DSM 7213, complete genomehypothetical protein4e-1166.6
NC_009706:3882500:388994638899463890128183Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein5e-1166.2
NC_015977:3215770:323249632324963232672177Roseburia hominis A2-183 chromosome, complete genomehypothetical protein2e-1064.7
NC_015977:2807782:283401428340142834193180Roseburia hominis A2-183 chromosome, complete genomehypothetical protein2e-1064.3
NC_014328:2990790:300050030005003000694195Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein5e-1063.2
NC_015172:850802:866990866990867163174Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomehypothetical protein9e-1062.4
NC_012658:3678000:369105636910563691250195Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative transposase1e-0962
NC_015977:3324000:332739333273933327572180Roseburia hominis A2-183 chromosome, complete genomehypothetical protein1e-0962
NC_015437:697051:7041617041617052281068Selenomonas sputigena ATCC 35185 chromosome, complete genomeDNA adenine methylase6e-0959.7
NC_008346:331820:345497345497345727231Syntrophomonas wolfei subsp. wolfei str. Goettingen, complete6e-0959.3
NC_004557:2037500:204821120482112048780570Clostridium tetani E88, complete genomeputative transposase1e-0858.5
NC_015172:1195782:121584512158451216027183Syntrophobotulus glycolicus DSM 8271 chromosome, complete genometranscriptional regulator, AraC family2e-0858.2
NC_015172:1002872:101047010104701010676207Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomehypothetical protein3e-0857.4
NC_015520:1683616:1701237170123717024151179Mahella australiensis 50-1 BON chromosome, complete genomehypothetical protein3e-0857.4
NC_016894:3935161:3935161393516139362191059Acetobacterium woodii DSM 1030 chromosome, complete genomeMerR family transcriptional regulator3e-0857
NC_010376:49185:517155171552617903Finegoldia magna ATCC 29328, complete genomehypothetical protein5e-0856.6
NC_013216:426877:439141439141440076936Desulfotomaculum acetoxidans DSM 771, complete genometranscriptional regulator, AraC family4e-0753.5