Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1282293 Clostridium difficile 630, complete genome

Start: 1282293, End: 1283006, Length: 714

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018704:2417902:242905824290582429768711Amphibacillus xylanus NBRC 15112, complete genomeputative two-component system response regulator1e-22106
NC_016894:77853:840308403084764735Acetobacterium woodii DSM 1030 chromosome, complete genometwo component transcriptional regulator5e-22104
NC_008261:576923:593925593925594641717Clostridium perfringens ATCC 13124, complete genomeDNA-binding response regulator2e-21102
NC_009922:42696:456394563946355717Alkaliphilus oremlandii OhILAs, complete genometwo component transcriptional regulator, LytTR family4e-21101
NC_013316:2033906:207459320745932075183591Clostridium difficile R20291, complete genomehypothetical protein7e-2097.4
NC_014624:287500:304428304428305174747Eubacterium limosum KIST612 chromosome, complete genomeResponse regulator of the LytR/AlgR family8e-1890.5
NC_011898:3159411:319241031924103193168759Clostridium cellulolyticum H10, complete genometwo component transcriptional regulator, LytTR family4e-1788.6
NC_016048:308342:328892328892329599708Oscillibacter valericigenes Sjm18-20, complete genomeputative two-component response regulator1e-1687
NC_012778:207415:217309217309218022714Eubacterium eligens ATCC 27750, complete genometwo-component system, LytT family, response regulator9e-1787
NC_013174:501326:500595500595501329735Jonesia denitrificans DSM 20603, complete genometwo component transcriptional regulator, LytTR family4e-1581.6
NC_015977:3424178:347917734791773479884708Roseburia hominis A2-183 chromosome, complete genomeresponse regulator of the lytr/algr family protein4e-1581.6
NC_015690:8614000:862677486267748627514741Paenibacillus mucilaginosus KNP414 chromosome, complete genometwo-component response regulator6e-1580.9
NC_014376:2921769:293831329383132939053741Clostridium saccharolyticum WM1 chromosome, complete genometwo component transcriptional regulator, LytTR family9e-1580.5
NC_016627:1485799:149181114918111492536726Clostridium clariflavum DSM 19732 chromosome, complete genomeresponse regulator of the LytR/AlgR family1e-1479.7
NC_016048:375676:399488399488400183696Oscillibacter valericigenes Sjm18-20, complete genomeputative two-component response regulator3e-1375.5
NC_014376:3796990:380806238080623808787726Clostridium saccharolyticum WM1 chromosome, complete genometwo component transcriptional regulator, LytTR family3e-1375.5
NC_014376:1842290:186064418606441861369726Clostridium saccharolyticum WM1 chromosome, complete genometwo component transcriptional regulator, LytTR family6e-1374.3
NC_014152:2849991:286797228679722868697726Thermincola sp. JR, complete genometwo component transcriptional regulator, LytTR family9e-1373.9
NC_014363:1973670:198281319828131983520708Olsenella uli DSM 7084 chromosome, complete genometwo component transcriptional regulator, LytTR family1e-1273.2
NC_015275:3407358:342575034257503426475726Clostridium lentocellum DSM 5427 chromosome, complete genometwo component transcriptional regulator, LytTR family5e-1271.2
NC_014614:608946:611958611958612692735Clostridium sticklandii, complete genomehypothetical protein4e-1168.6
NC_014616:54500:567695676957485717Bifidobacterium bifidum S17 chromosome, complete genometwo-component response regulator8e-1167.4
NC_009828:600349:601856601856602527672Thermotoga lettingae TMO, complete genometwo component transcriptional regulator, LytTR family1e-1066.6
NC_015172:850802:866232866232866960729Syntrophobotulus glycolicus DSM 8271 chromosome, complete genometwo component transcriptional regulator, LytTR family4e-1065.1
NC_015977:3424178:347591234759123476646735Roseburia hominis A2-183 chromosome, complete genometwo-component system response regulator protein5e-1064.7
NC_007907:2249607:225088322508832251608726Desulfitobacterium hafniense Y51, complete genomehypothetical protein8e-1063.9
NC_014624:3316916:332634833263483326935588Eubacterium limosum KIST612 chromosome, complete genomeLytTR family two component transcriptional regulator2e-0963.2
NC_007644:1638083:165823516582351658972738Moorella thermoacetica ATCC 39073, complete genometranscriptional regulator, LytR/AlgR family2e-0962.8
NC_014633:837588:857228857228857983756Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceLytTR family two component transcriptional regulator7e-0961.2
NC_020210:2969862:296986229698622970776915Geobacillus sp. GHH01, complete genomeresponse regulator receiver protein8e-0960.8
NC_012778:841934:882083882083882793711Eubacterium eligens ATCC 27750, complete genomehypothetical protein9e-0960.5
NC_014934:11341:366453664537337693Cellulophaga algicola DSM 14237 chromosome, complete genometwo component transcriptional regulator, lyttr family2e-0859.7
NC_013222:2795919:281526028152602815907648Robiginitalea biformata HTCC2501, complete genometwo-component system response regulator protein3e-0858.9
NC_010658:2529033:255507825550782555812735Shigella boydii CDC 3083-94, complete genomeresponse regulator7e-0857.8
NC_008258:2473000:249696424969642497698735Shigella flexneri 5 str. 8401, complete genomeputative 2-component transcriptional regulator7e-0857.8
NC_004337:2478461:250322425032242503958735Shigella flexneri 2a str. 301, complete genomeputative 2-component transcriptional regulator7e-0857.8
CP002516:1419413:142028314202831421017735Escherichia coli KO11, complete genometwo component transcriptional regulator, LytTR family7e-0857.8
NC_013941:2928000:296958729695872970321735Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein7e-0857.8
NC_016822:2678691:270562327056232706357735Shigella sonnei 53G, complete genomeLytTR family two component transcriptional regulator7e-0857.8
NC_016902:1419413:142028314202831421017735Escherichia coli KO11FL chromosome, complete genomeLytTR family two component transcriptional regulator7e-0857.8
NC_004668:3053119:306801830680183068746729Enterococcus faecalis V583, complete genomeresponse regulator9e-0857.4
NC_017316:2581781:259771425977142598442729Enterococcus faecalis OG1RF chromosome, complete genomeresponse regulator9e-0857
NC_011969:1816746:183901118390111839655645Bacillus cereus Q1 chromosome, complete genomemethyl-accepting/DNA response regulator1e-0757
NC_009615:2311352:231296223129622313666705Parabacteroides distasonis ATCC 8503 chromosome, complete genometwo-component system response regulator1e-0756.6
NC_015167:313506:335892335892336584693Cellulophaga lytica DSM 7489 chromosome, complete genomeLytTR family two component transcriptional regulator2e-0756.2
NC_015589:3852217:386341738634173864118702Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeresponse regulator receiver2e-0755.8
NC_012778:1946924:197010019701001970786687Eubacterium eligens ATCC 27750, complete genometwo-component system, LytT family, response regulator LytT2e-0755.8
NC_012673:2064298:208338020833802084360981Exiguobacterium sp. AT1b, complete genomeresponse regulator receiver protein5e-0754.7
NC_010520:1146000:116684911668491167565717Clostridium botulinum A3 str. Loch Maree, complete genomeLytTr DNA-binding domain family6e-0754.3
NC_008536:1778500:179196917919691792745777Solibacter usitatus Ellin6076, complete genomeresponse regulator receiver protein1e-0653.9
NC_011830:3904034:392032539203253921080756Desulfitobacterium hafniense DCB-2, complete genometwo component transcriptional regulator, LytTR family1e-0653.5
NC_009616:99647:116610116610117290681Thermosipho melanesiensis BI429 chromosome, complete genomeLytTR family two component transcriptional regulator2e-0653.1
NC_014633:583858:604072604072604797726Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceLytTR family two component transcriptional regulator2e-0653.1
NC_020541:3655223:367719736771973678060864Rhodanobacter sp. 2APBS1, complete genomeresponse regulator of the LytR/AlgR family1e-0653.1
NC_013132:5250385:525430752543075254627321Chitinophaga pinensis DSM 2588, complete genomeresponse regulator receiver protein2e-0652.8
NC_009785:387910:407897407897408631735Streptococcus gordonii str. Challis substr. CH1, complete genomeResponse regulator of the LytR/AlgR family4e-0651.6
NC_019968:1304450:131481713148171315533717Prevotella dentalis DSM 3688 chromosome 2, complete sequenceresponse regulator of the LytR/AlgR family5e-0651.6
NC_019968:1084288:112808911280891128805717Prevotella dentalis DSM 3688 chromosome 2, complete sequenceresponse regulator of the LytR/AlgR family5e-0651.6