Pre_GI: BLASTP Hits

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Query: NC_009089:1093832:1115979 Clostridium difficile 630, complete genome

Start: 1115979, End: 1117472, Length: 1494

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009089:1093832:10873831087383114439857016Clostridium difficile 630, complete genome01038
NC_017179:1683199:1706968170696817085031536Clostridium difficile BI1, complete genomephage protein0682
NC_010001:3614314:3632037363203736335931557Clostridium phytofermentans ISDg, complete genomephage head morphogenesis protein, SPP1 gp7 family2e-102373
NC_017294:115500:1345681345681361511584Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomephage head morphogenesis protein3e-102372
NC_015913:117966:1352581352581368411584Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomehead morphogenesis protein3e-102372
NC_013517:1501276:1502714150271415046391926Sebaldella termitidis ATCC 33386, complete genomephage head morphogenesis protein, SPP1 gp7 family1e-98360
NC_012658:1810640:1830909183090918319311023Clostridium botulinum Ba4 str. 657 chromosome, complete genomephage head morphogenesis protein, SPP1 gp7 family9e-78291
NC_017297:2531750:2548457254845725494791023Clostridium botulinum F str. 230613 chromosome, complete genomephage head morphogenesis protein6e-77288
NC_009012:2927793:2948505294850529499141410Clostridium thermocellum ATCC 27405, complete genomephage putative head morphogenesis protein, SPP1 gp7 family2e-54213
NC_020134:420500:4352584352584365891332Clostridium stercorarium subsp. stercorarium DSM 8532, completephage head morphogenesis protein, SPP1 gp7 family1e-51204
NC_014376:1472304:1494842149484214964161575Clostridium saccharolyticum WM1 chromosome, complete genomephage head morphogenesis protein, SPP1 gp7 family4e-49196
NC_014498:1983740:2009696200969620112791584Streptococcus pneumoniae 670-6B chromosome, complete genomephage putative head morphogenesis protein, SPP1 gp7 family4e-41169
NC_012466:1754388:1764250176425017658331584Streptococcus pneumoniae JJA, complete genomephage putative head morphogenesis protein, SPP1 gp7 family9e-41168
NC_016077:1388775:1409072140907214108771806Acidaminococcus intestini RyC-MR95 chromosome, complete genomeputative head protein6e-40165
NC_015519:1081539:1098996109899611005371542Tepidanaerobacter sp. Re1 chromosome, complete genomephage head morphogenesis protein, SPP1 gp7 family3e-39163
NC_009674:2985878:3004242300424230052671026Bacillus cytotoxicus NVH 391-98 chromosome, complete genomeSPP1 family phage head morphogenesis protein2e-33144
NC_017200:1137639:1137639113763911386641026Bacillus thuringiensis serovar finitimus YBT-020 chromosome,SPP1 family phage head morphogenesis protein1e-31138
NC_014319:1613611:162675116267511627695945Leuconostoc gasicomitatum LMG 18811, complete genomephage protein4e-31136
NC_017294:403422:412234412234413118885Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomehypothetical protein2e-28127
NC_008530:646207:6599656599656614971533Lactobacillus gasseri ATCC 33323, complete genomePhage Mu protein F like protein2e-27124
NC_017353:887581:906346906346907296951Staphylococcus lugdunensis N920143, complete genomephage Mu protein F-like protein1e-24115
NC_012891:1573435:158791015879101588818909Streptococcus dysgalactiae subsp. equisimilis GGS_124 chromosome 1,phage protein1e-24114
NC_008024:804157:821155821155822063909Streptococcus pyogenes MGAS10750, complete genomephage protein1e-24114
NC_008022:771767:789889789889790797909Streptococcus pyogenes MGAS10270, complete genomephage protein1e-24114
NC_015930:1105882:1126065112606511271621098Lactococcus garvieae ATCC 49156, complete genomephage minor head protein2e-24114
NC_009332:1050353:1050353105035310517951443Streptococcus pyogenes str. Manfredo chromosome, complete genomephage minor head protein9e-24112
NC_011375:749693:7677477677477691891443Streptococcus pyogenes NZ131 chromosome, complete genomephage-associated protein9e-24112
NC_006086:35599:5346053460549111452Streptococcus pyogenes MGAS10394, complete genomeunknown phage protein1e-23111
NC_004070:1431146:1431146143114614325941449Streptococcus pyogenes MGAS315, complete genomehypothetical protein1e-23111
NC_004606:446427:4642914642914657391449Streptococcus pyogenes SSI-1, complete genomehypothetical protein1e-23111
NC_015558:1425271:143049614304961431416921Streptococcus parauberis KCTC 11537 chromosome, complete genomephage protein2e-23110
NC_007297:1406796:1405391140539114068301440Streptococcus pyogenes MGAS5005, complete genomephage protein3e-23110
NC_008021:1401249:1399844139984414012921449Streptococcus pyogenes MGAS9429, complete genomephage protein3e-23110
NC_012471:2080902:2084998208499820864461449Streptococcus equi subsp. equi 4047, complete genomephage minor head protein4e-23109
NC_020450:1726234:1735896173589617370021107Lactococcus lactis subsp. lactis IO-1 DNA, complete genomeNAD+--asparagine ADP-ribosyltransferase6e-23109
NC_007297:1001981:100307110030711003979909Streptococcus pyogenes MGAS5005, complete genomephage protein7e-23108
NC_015737:53682:643056430565192888Clostridium sp. SY8519, complete genomehypothetical protein3e-22107
NC_014925:578759:6030636030636044121350Staphylococcus pseudintermedius HKU10-03 chromosome, completehypothetical protein5e-22106
NC_013893:2310495:233131623313162332281966Staphylococcus lugdunensis HKU09-01 chromosome, complete genomehypothetical protein8e-22105
NC_008527:1036757:1054382105438210554251044Lactococcus lactis subsp. cremoris SK11, complete genomePhage Mu protein F like protein1e-21104
NC_015601:627217:6469536469536483081356Erysipelothrix rhusiopathiae str. Fujisawa, complete genomephage head morphogenesis protein, SPP1 gp7 family4e-21103
NC_015558:1389369:139266013926601393580921Streptococcus parauberis KCTC 11537 chromosome, complete genomephage protein8e-2099
NC_017351:643674:663233663233664228996Staphylococcus aureus subsp. aureus 11819-97 chromosome, completephage head morphogenesis , SPP1 gp7 family domain protein1e-1997.8
NC_009487:921884:940114940114941109996Staphylococcus aureus subsp. aureus JH9 chromosome, completeSPP1 family phage head morphogenesis protein1e-1997.8
NC_009632:921759:939989939989940984996Staphylococcus aureus subsp. aureus JH1 chromosome, completeSPP1 family phage head morphogenesis protein1e-1997.8
NC_007795:1922000:194623419462341947229996Staphylococcus aureus subsp. aureus NCTC 8325, complete genomephage putative head morphogenesis protein, SPP1 gp7 family domain protein2e-1997.4
NC_009782:920272:938212938212939207996Staphylococcus aureus subsp. aureus Mu3, complete genomehypothetical protein2e-1997.4
NC_002758:918827:936768936768937763996Staphylococcus aureus subsp. aureus Mu50, complete genomehypothetical protein2e-1997.4
NC_009641:1979053:200238720023872003382996Staphylococcus aureus subsp. aureus str. Newman chromosome,phage head morphogenesis protein2e-1997.4
NC_009641:1105075:111874611187461119741996Staphylococcus aureus subsp. aureus str. Newman chromosome,phage head morphogenesis protein2e-1997.4
NC_007622:1842000:186698018669801867912933Staphylococcus aureus RF122, complete genomehypothetical phage-related protein6e-1995.9
NC_014377:1227850:124857012485701249451882Thermosediminibacter oceani DSM 16646 chromosome, complete genomephage head morphogenesis protein, SPP1 gp7 family7e-1995.9
NC_014554:2159782:2162547216254721642321686Lactobacillus plantarum subsp. plantarum ST-III chromosome,prophage minor head protein1e-1895.1
NC_013891:1639694:164959016495901650354765Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomephage minor head protein, putative2e-1687.8
NC_015425:1295261:1312456131245613137271272Clostridium botulinum BKT015925 chromosome, complete genomeminor head protein5e-1686.3
NC_008593:1362218:1380741138074113820121272Clostridium novyi NT, complete genomeminor head protein7e-1582.4
NC_014307:1:2937629376305271152Ralstonia solanacearum CFBP2957 chromosome, complete genomemembrane protein8e-1479
NC_003485:1061344:1065343106534310669681626Streptococcus pyogenes MGAS8232, complete genomehypothetical protein8e-1272.4
NC_011375:1482324:1482897148289714844591563Streptococcus pyogenes NZ131 chromosome, complete genomehypothetical protein2e-1170.9
NC_008021:779380:7968527968527984141563Streptococcus pyogenes MGAS9429, complete genomephage protein4e-1170.1
NC_002737:780857:7979177979177995421626Streptococcus pyogenes M1 GAS, complete genomehypothetical protein6e-1169.3
NC_012471:1752483:1763176176317617647411566Streptococcus equi subsp. equi 4047, complete genomephage Mu protein F like protein1e-1068.2
NC_021182:2765000:278014027801402781042903Clostridium pasteurianum BC1, complete genomephage putative head morphogenesis protein, SPP1 gp7 family2e-0964.3
NC_012491:3736167:373616737361673737075909Brevibacillus brevis NBRC 100599, complete genomeputative minor head protein3e-0963.9
NC_009656:2422083:2444251244425124453301080Pseudomonas aeruginosa PA7 chromosome, complete genomehypothetical protein1e-0862
NC_016887:1680338:1687707168770716927765070Nocardia cyriacigeorgica GUH-2, complete genomehypothetical protein2e-0860.8
NC_019977:1189242:120847512084751209332858Methanomethylovorans hollandica DSM 15978, complete genomephage putative head morphogenesis protein, SPP1 gp7 family4e-0859.7
NC_010322:3831444:3847681384768138487241044Pseudomonas putida GB-1 chromosome, complete genomeSPP1 family phage head morphogenesis protein8e-0858.9
NC_013198:1095591:112621111262111127203993Lactobacillus rhamnosus GG, complete genomephage protein, Mu protein F4e-0756.6
NC_008525:780500:799459799459800424966Pediococcus pentosaceus ATCC 25745, complete genomePhage Mu protein F like protein5e-0756.2
NC_019673:1456999:1466696146669614679731278Saccharothrix espanaensis DSM 44229 complete genomehypothetical protein8e-0755.5