Pre_GI: BLASTP Hits

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Query: NC_009089:1093832:1114550 Clostridium difficile 630, complete genome

Start: 1114550, End: 1115989, Length: 1440

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1683199:1705536170553617069781443Clostridium difficile BI1, complete genomephage portal protein0883
NC_014551:576000:5975255975255989761452Bacillus amyloliquefaciens DSM 7, complete genomephage portal protein, SPP1 family4e-97355
NC_017341:1976000:2000857200085720022751419Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,phage portal protein, SPP1 family7e-84311
NC_009632:361229:3802933802933817711479Staphylococcus aureus subsp. aureus JH1 chromosome, completeSPP1 family phage portal protein2e-83310
NC_009487:362475:3802833802833817011419Staphylococcus aureus subsp. aureus JH9 chromosome, completeSPP1 family phage portal protein2e-83310
NC_007168:2349894:2376770237677023781131344Staphylococcus haemolyticus JCSC1435, complete genomehypothetical protein6e-81301
NC_020134:420500:4338074338074352401434Clostridium stercorarium subsp. stercorarium DSM 8532, completeportal protein1e-74280
NC_009012:2927793:2946915294691529483481434Clostridium thermocellum ATCC 27405, complete genomephage portal protein, SPP1 family1e-74280
NC_015519:1081539:1097522109752210989641443Tepidanaerobacter sp. Re1 chromosome, complete genomephage portal protein, SPP1 family1e-73277
NC_017297:2531750:2549469254946925509201452Clostridium botulinum F str. 230613 chromosome, complete genomephage portal protein, SPP1 family1e-65251
NC_010001:3614314:3633580363358036349681389Clostridium phytofermentans ISDg, complete genomephage portal protein, SPP1 family6e-65248
NC_012658:1810640:1829468182946818309191452Clostridium botulinum Ba4 str. 657 chromosome, complete genomephage portal protein, SPP1 family2e-64247
NC_014376:1472304:1493436149343614948421407Clostridium saccharolyticum WM1 chromosome, complete genomephage portal protein, SPP1 family3e-58226
NC_008530:646207:6585636585636599751413Lactobacillus gasseri ATCC 33323, complete genomePhage portal protein, SPP1 Gp6-like2e-50200
NC_013517:1501276:1501276150127615027271452Sebaldella termitidis ATCC 33386, complete genomeportal protein SPP19e-46184
NC_015425:1295261:1311015131101513124691455Clostridium botulinum BKT015925 chromosome, complete genomephage portal protein, SPP1 Gp6-like protein7e-44178
NC_015913:117966:1338771338771352651389Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomephage portal protein8e-43175
NC_008593:1362218:1381999138199913834621464Clostridium novyi NT, complete genomePhage portal protein, SPP1 Gp6-like2e-42174
NC_017294:115500:1332501332501345751326Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomephage portal protein, SPP1 family6e-42172
NC_017294:403422:4109454109454121561212Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomephage portal protein, SPP1 family6e-27122
NC_004668:295417:3089483089483104801533Enterococcus faecalis V583, complete genomeportal protein3e-26120
NC_006322:1415863:1442488144248814439031416Bacillus licheniformis ATCC 14580, complete genomehypothetical protein4e-1686.3
NC_006270:1415001:1441626144162614430411416Bacillus licheniformis ATCC 14580, complete genomephage related protein4e-1686.3
NC_020272:2748733:2778964277896427803671404Bacillus amyloliquefaciens IT-45, complete genomephage Portal protein5e-1686.3
NC_017200:1137639:1136309113630911376521344Bacillus thuringiensis serovar finitimus YBT-020 chromosome,SPP1 family phage portal protein4e-1583.2
NC_012491:3736167:3737072373707237386191548Brevibacillus brevis NBRC 100599, complete genomeputative portal protein7e-1582.4
NC_009674:2985878:3005254300525430066091356Bacillus cytotoxicus NVH 391-98 chromosome, complete genomeSPP1 family phage portal protein1e-1481.6
NC_014925:578759:6016256016256030701446Staphylococcus pseudintermedius HKU10-03 chromosome, completePhage portal protein6e-1479.3
NC_017188:2221705:2224665222466522260981434Bacillus amyloliquefaciens TA208 chromosome, complete genomehypothetical protein2e-1377.8
NC_017191:2223740:2226700222670022280761377Bacillus amyloliquefaciens XH7 chromosome, complete genomephage-like protein2e-1377.8
NC_013893:2310495:2332268233226823337191452Staphylococcus lugdunensis HKU09-01 chromosome, complete genomephage protein3e-1377
NC_011375:749693:7662497662497677811533Streptococcus pyogenes NZ131 chromosome, complete genomephage-associated protein8e-1272
NC_012471:2080902:2086406208640620879381533Streptococcus equi subsp. equi 4047, complete genomephage portal protein2e-1171.2
NC_013891:1639694:1650344165034416517351392Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomephage portal protein, SPP1, putative2e-1171.2
NC_009332:1050353:1051761105176110532931533Streptococcus pyogenes str. Manfredo chromosome, complete genomephage portal protein2e-1170.9
NC_008021:1401249:1401249140124914027811533Streptococcus pyogenes MGAS9429, complete genomeportal protein4e-1170.1
NC_007297:1406796:1406796140679614083281533Streptococcus pyogenes MGAS5005, complete genomeportal protein4e-1170.1
NC_004606:446427:4627994627994643311533Streptococcus pyogenes SSI-1, complete genomehypothetical protein3e-1170.1
NC_006086:35599:5197151971535031533Streptococcus pyogenes MGAS10394, complete genomePortal protein3e-1170.1
NC_009641:327325:3397903397903412141425Staphylococcus aureus subsp. aureus str. Newman chromosome,phage portal protein3e-1170.1
NC_004070:1431146:1432554143255414340231470Streptococcus pyogenes MGAS315, complete genomehypothetical protein3e-1170.1
NC_008525:780500:7980757980757994781404Pediococcus pentosaceus ATCC 25745, complete genomePhage portal protein, SPP1 Gp6-like1e-1068.2
NC_009641:1105075:1117204111720411187391536Staphylococcus aureus subsp. aureus str. Newman chromosome,phage portal protein3e-1067
NC_009641:1979053:2003389200338920049241536Staphylococcus aureus subsp. aureus str. Newman chromosome,phage portal protein3e-1067
NC_012466:1754388:1765796176579617670971302Streptococcus pneumoniae JJA, complete genomephage portal protein, SPP1 family3e-1067
NC_014498:1983740:2011242201124220125431302Streptococcus pneumoniae 670-6B chromosome, complete genomephage portal protein, SPP1 family3e-1067
NC_007795:1922000:1947236194723619487711536Staphylococcus aureus subsp. aureus NCTC 8325, complete genomephage portal protein, SPP1 family4e-1066.6
NC_012891:1573435:1588787158878715901121326Streptococcus dysgalactiae subsp. equisimilis GGS_124 chromosome 1,portal protein5e-1066.2
NC_017351:643674:6616886616886632261539Staphylococcus aureus subsp. aureus 11819-97 chromosome, completephage portal protein, SPP1 family7e-1065.9
NC_016641:2587000:2610361261036126116711311Paenibacillus terrae HPL-003 chromosome, complete genomehypothetical protein6e-1065.9
NC_012673:1:1973519735213181584Exiguobacterium sp. AT1b, complete genomeportal protein SPP11e-0965.1
NC_007622:1842000:1867976186797618695171542Staphylococcus aureus RF122, complete genomehypothetical phage-related protein2e-0964.3
NC_009632:921759:9384449384449399821539Staphylococcus aureus subsp. aureus JH1 chromosome, completeSPP1 family phage portal protein5e-0963.2
NC_009487:921884:9385699385699401071539Staphylococcus aureus subsp. aureus JH9 chromosome, completeSPP1 family phage portal protein5e-0963.2
NC_002758:918827:9352269352269367611536Staphylococcus aureus subsp. aureus Mu50, complete genomehypothetical protein5e-0962.8
NC_009782:920272:9366709366709382051536Staphylococcus aureus subsp. aureus Mu3, complete genomehypothetical protein5e-0962.8
NC_003485:1061344:1066949106694910684511503Streptococcus pyogenes MGAS8232, complete genomephage protein8e-0962.4
NC_014377:961259:9875359875359888451311Thermosediminibacter oceani DSM 16646 chromosome, complete genomeBacteriophage portal protein, SPP1 Gp67e-0962.4
NC_008021:779380:7953697953697968711503Streptococcus pyogenes MGAS9429, complete genomeportal protein7e-0962.4
NC_011375:1482324:1484440148444014859421503Streptococcus pyogenes NZ131 chromosome, complete genomehypothetical protein7e-0962.4
NC_014377:1227850:1249444124944412507211278Thermosediminibacter oceani DSM 16646 chromosome, complete genomephage portal protein, SPP1 family1e-0861.6
NC_008024:804157:8198618198618211861326Streptococcus pyogenes MGAS10750, complete genomePortal protein2e-0860.8
NC_008022:771767:7885957885957899201326Streptococcus pyogenes MGAS10270, complete genomePortal protein2e-0860.8
NC_014319:1613611:1627688162768816292531566Leuconostoc gasicomitatum LMG 18811, complete genomephage portal protein3e-0860.5
NC_010520:2101515:2125335212533521266031269Clostridium botulinum A3 str. Loch Maree, complete genomephage portal protein, SPP1 family2e-0757.8
NC_008527:1036757:1053017105301710543781362Lactococcus lactis subsp. cremoris SK11, complete genomePhage portal protein, SPP1 Gp6-like2e-0757.8
NC_007297:1001981:1003948100394810052731326Streptococcus pyogenes MGAS5005, complete genomeportal protein2e-0757.8
NC_008497:1111891:1112747111274711142701524Lactobacillus brevis ATCC 367, complete genomePhage portal protein, SPP1 Gp6-like2e-0757.4
NC_012471:1752483:1764734176473417662361503Streptococcus equi subsp. equi 4047, complete genomephage portal protein3e-0757
NC_015558:1389369:1393591139359113951291539Streptococcus parauberis KCTC 11537 chromosome, complete genomeportal protein5e-0756.2
NC_008526:1924761:1926061192606119274881428Lactobacillus casei ATCC 334, complete genomePhage portal protein, SPP1 Gp6-like7e-0755.8
NC_015558:1425271:1431403143140314327131311Streptococcus parauberis KCTC 11537 chromosome, complete genomeportal protein9e-0755.5
NC_010516:2305110:2327007232700723282841278Clostridium botulinum B1 str. Okra, complete genomephage portal protein, SPP1 family3e-0653.9
NC_009253:2315958:2324311232431123256331323Desulfotomaculum reducens MI-1 chromosome, complete genomephage portal protein, SPP13e-0653.5
NC_013171:896802:9149749149749164431470Anaerococcus prevotii DSM 20548, complete genomephage portal protein, SPP1 family5e-0653.1
NC_009253:389835:3971033971033984251323Desulfotomaculum reducens MI-1 chromosome, complete genomephage portal protein, SPP15e-0652.8