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Query: NC_009089:1093832:1113303 Clostridium difficile 630, complete genome

Start: 1113303, End: 1114544, Length: 1242

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009089:1093832:10873831087383114439857016Clostridium difficile 630, complete genome0848
NC_013315:1679000:1696262169626216975151254Clostridium difficile CD196 chromosome, complete genomephage terminase large subunit0836
NC_017179:1683199:1704280170428017055301251Clostridium difficile BI1, complete genomephage terminase large subunit0836
NC_017294:403422:4096454096454108861242Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomePBSX family phage terminase large subunit9e-54211
NC_015913:117966:1317191317191329661248Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomePBSX family phage terminase, large subunit6e-54211
NC_017294:115500:1310291310291322761248Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomePBSX family phage terminase large subunit6e-54211
NC_013517:1480368:1499974149997415012661293Sebaldella termitidis ATCC 33386, complete genomephage terminase, large subunit, PBSX family3e-52206
NC_014633:99744:1218591218591231271269Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencephage terminase, large subunit, PBSX family4e-51202
NC_008021:779380:7940627940627953571296Streptococcus pyogenes MGAS9429, complete genometerminase large subunit5e-49195
NC_002737:780857:7951337951337964221290Streptococcus pyogenes M1 GAS, complete genomeputative terminase, large subunit - phage associated6e-49195
NC_003485:1061344:1068463106846310697581296Streptococcus pyogenes MGAS8232, complete genomeputative terminase, large subunit1e-48194
NC_011375:1482324:1485954148595414872431290Streptococcus pyogenes NZ131 chromosome, complete genomeLarge terminase7e-49194
NC_009674:2985878:3006621300662130079251305Bacillus cytotoxicus NVH 391-98 chromosome, complete genomePBSX family phage terminase large subunit9e-44177
NC_012466:1754388:1767277176727717685751299Streptococcus pneumoniae JJA, complete genomephage terminase, large subunit, pbsx family7e-43175
NC_014498:1983740:2012723201272320140211299Streptococcus pneumoniae 670-6B chromosome, complete genomephage terminase large subunit1e-42174
NC_012563:2680246:2679018267901826802561239Clostridium botulinum A2 str. Kyoto, complete genomephage terminase, large subunit, pbsx family1e-41170
NC_007622:1842000:1869528186952818708171290Staphylococcus aureus RF122, complete genomephage-associated terminase large subunit2e-41170
NC_014925:578759:6003396003396016131275Staphylococcus pseudintermedius HKU10-03 chromosome, completePhage terminase, large subunit5e-41169
NC_009513:870837:8859128859128872071296Lactobacillus reuteri F275, complete genomephage terminase, large subunit, PBSX family4e-41169
NC_010609:880196:8952718952718965661296Lactobacillus reuteri JCM 1112, complete genomephage terminase4e-41169
NC_009632:921759:9371389371389384331296Staphylococcus aureus subsp. aureus JH1 chromosome, completePBSX family phage terminase large subunit2e-39163
NC_009487:921884:9372639372639385581296Staphylococcus aureus subsp. aureus JH9 chromosome, completePBSX family phage terminase large subunit2e-39163
NC_021182:1911088:1925829192582919270701242Clostridium pasteurianum BC1, complete genomephage terminase, large subunit, PBSX family1e-36154
NC_014319:1613611:1629255162925516305381284Leuconostoc gasicomitatum LMG 18811, complete genomephage terminase large subunit1e-33144
NC_009012:2927793:2945643294564329468991257Clostridium thermocellum ATCC 27405, complete genomephage terminase, large subunit, PBSX family1e-30134
NC_007503:1486000:1503623150362315048851263Carboxydothermus hydrogenoformans Z-2901, complete genomeprophage LambdaCh01, terminase, large subunit, PBSX family1e-29130
NC_019842:1172944:1192884119288411941581275Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,terminase large subunit4e-29129
NC_014551:576000:5962295962295975031275Bacillus amyloliquefaciens DSM 7, complete genomephage terminase, large subunit, pbsx family1e-28127
NC_007168:2349894:2378207237820723794721266Staphylococcus haemolyticus JCSC1435, complete genomeputative phage terminase large subunit8e-28125
NC_008023:1426687:1426687142668714279731287Streptococcus pyogenes MGAS2096, complete genomeTerminase large subunit8e-28125
NC_008021:1401249:1402797140279714040831287Streptococcus pyogenes MGAS9429, complete genometerminase large subunit8e-28125
NC_007297:1406796:1408344140834414096211278Streptococcus pyogenes MGAS5005, complete genometerminase large subunit7e-28125
NC_012471:2080902:2087954208795420892311278Streptococcus equi subsp. equi 4047, complete genomephage terminase, large subunit2e-27124
NC_004606:446427:4615064615064627831278Streptococcus pyogenes SSI-1, complete genomehypothetical protein2e-27124
NC_004070:1431146:1434102143410214353791278Streptococcus pyogenes MGAS315, complete genomeputative terminase large subunit - phage associated2e-27124
NC_011375:749693:7649567649567662331278Streptococcus pyogenes NZ131 chromosome, complete genometerminase large subunit2e-27123
NC_006086:35599:5066950669519551287Streptococcus pyogenes MGAS10394, complete genomeTerminase large subunit2e-27123
NC_009332:1050353:1053309105330910545861278Streptococcus pyogenes str. Manfredo chromosome, complete genomephage terminase, large subunit2e-27123
NC_013893:2310495:2333731233373123350051275Staphylococcus lugdunensis HKU09-01 chromosome, complete genomePhage terminase, large subunit1e-26120
NC_000964:2670288:2687532268753226888271296Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein4e-26119
NC_014328:3434478:3454202345420234554341233Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative phage terminaselarge subunit2e-25117
NC_006270:1415001:1440355144035514416291275Bacillus licheniformis ATCC 14580, complete genomePhage terminase, large subunit2e-25117
NC_017353:887581:9035189035189047981281Staphylococcus lugdunensis N920143, complete genomephage terminase large subunit family protein2e-25117
NC_006322:1415863:1441214144121414424911278Bacillus licheniformis ATCC 14580, complete genomehypothetical protein2e-25117
NC_009641:1979053:2004935200493520062781344Staphylococcus aureus subsp. aureus str. Newman chromosome,phage terminase large subunit3e-25116
NC_007795:1922000:1948782194878219500591278Staphylococcus aureus subsp. aureus NCTC 8325, complete genomephage terminase, large subunit, PBSX family3e-25116
NC_009641:1105075:1115916111591611171931278Staphylococcus aureus subsp. aureus str. Newman chromosome,phage terminase large subunit3e-25116
NC_017351:643674:6604006604006616771278Staphylococcus aureus subsp. aureus 11819-97 chromosome, completephage terminase, large subunit, PBSX family3e-25116
NC_002758:918827:9339389339389352151278Staphylococcus aureus subsp. aureus Mu50, complete genomelarge terminase3e-25116
NC_009782:920272:9353829353829366591278Staphylococcus aureus subsp. aureus Mu3, complete genomehypothetical protein3e-25116
NC_014976:627935:6732386732386745331296Bacillus subtilis BSn5 chromosome, complete genomeputative phage-related terminase large subunit3e-25116
NC_016077:1278104:1283833128383312850891257Acidaminococcus intestini RyC-MR95 chromosome, complete genomephage terminase large subunit6e-25115
NC_009706:3341250:3341250334125033426021353Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein1e-24114
NC_011837:3272752:3272752327275232741041353Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-24114
NC_021171:254000:2593892593892607141326Bacillus sp. 1NLA3E, complete genomeputative phage-like terminase large subunit, skin element YqaT1e-24114
NC_015425:1295261:1309743130974313110021260Clostridium botulinum BKT015925 chromosome, complete genomephage terminase, large subunit, PBSX family3e-24113
UCMB5137:861734:8625318625318638291299Bacillus atrophaeus UCMB-5137PBSX defective prophage terminase (large subunit)4e-24112
NC_016935:6464201:6474500647450064757831284Paenibacillus mucilaginosus 3016 chromosome, complete genomepbsx family phage terminase large subunit4e-24112
NC_012471:1752483:1766248176624817674951248Streptococcus equi subsp. equi 4047, complete genomephage terminase, large subunit6e-24112
NC_012658:1810640:1828195182819518294541260Clostridium botulinum Ba4 str. 657 chromosome, complete genomephage terminase large subunit, PBSX family1e-23110
NC_012891:1573435:1590112159011215913861275Streptococcus dysgalactiae subsp. equisimilis GGS_124 chromosome 1,terminase large subunit1e-22107
NC_014376:1472304:1492139149213914934251287Clostridium saccharolyticum WM1 chromosome, complete genomephage terminase, large subunit, PBSX family8e-22105
NC_007297:1001981:1005273100527310065471275Streptococcus pyogenes MGAS5005, complete genometerminase large subunit9e-22105
NC_006582:2944237:2971567297156729728471281Bacillus clausii KSM-K16, complete genometerminase large subunit G2p1e-21104
NC_006270:2850354:2855237285523728565321296Bacillus licheniformis ATCC 14580, complete genomePhage terminase, large subunit protein1e-21104
NC_006322:2851215:2856098285609828573931296Bacillus licheniformis ATCC 14580, complete genomeYqaT1e-21104
NC_008022:771767:7872977872977885951299Streptococcus pyogenes MGAS10270, complete genomeTerminase large subunit1e-21104
NC_008024:804157:8185638185638198611299Streptococcus pyogenes MGAS10750, complete genomeTerminase large subunit1e-21104
NC_015144:237467:2544482544482557881341Weeksella virosa DSM 16922 chromosome, complete genomephage terminase, large subunit, PBSX family4e-21102
NC_009495:2479465:2500396250039625017421347Clostridium botulinum A str. ATCC 3502 chromosome, complete genometerminase large subunit6e-21102
NC_009615:1001744:1013850101385010151181269Parabacteroides distasonis ATCC 8503 chromosome, complete genomephage large subunit terminase2e-20100
NC_013170:311045:3313493313493326291281Cryptobacterium curtum DSM 15641, complete genomephage terminase, large subunit, PBSX family4e-1996.3
NC_020450:1726234:1738930173893017402221293Lactococcus lactis subsp. lactis IO-1 DNA, complete genometerminase, large subunit, PBSX family5e-1789.4
NC_009848:2755874:2774509277450927758221314Bacillus pumilus SAFR-032, complete genometerminase large subunit1e-1687.8
NC_013282:1200993:1228537122853712297661230Cronobacter turicensis, complete genomehypothetical protein3e-1686.7
NC_015519:1081539:1096255109625510975081254Tepidanaerobacter sp. Re1 chromosome, complete genomephage terminase, large subunit, PBSX family6e-1479
NC_020054:2260500:2283650228365022849781329Fibrella aestuarina BUZ 2 drat genomePBSX phage terminase large subunit8e-1478.6
NC_007712:2806500:2842271284227128435121242Sodalis glossinidius str. 'morsitans', complete genomehypothetical protein2e-1377.4
NC_014657:914071:9187599187599199731215Caldicellulosiruptor owensensis OL chromosome, complete genomephage terminase, large subunit, pbsx family4e-1376.3
NC_017045:119046:1249451249451262431299Riemerella anatipestifer ATCC 11845 = DSM 15868 chromosome,pbsx family phage terminase large subunit5e-1272.8
NC_014738:2094000:2119696211969621209941299Riemerella anatipestifer ATCC 11845 = DSM 15868 chromosome,pbsx family phage terminase large subunit5e-1272.8
NC_015859:952500:9798429798429810441203Corynebacterium variabile DSM 44702 chromosome, complete genomehypothetical protein1e-1068.2
NC_004557:1141558:1154592115459211559351344Clostridium tetani E88, complete genomephage terminase large subunit3e-0963.5
NC_014136:1879049:1897368189736818986661299Leuconostoc kimchii IMSNU11154 chromosome, complete genomeputative terminase large subunit phage5e-0962.8
NC_013171:896802:9137289137289149661239Anaerococcus prevotii DSM 20548, complete genomephage terminase, large subunit, PBSX family7e-0962.4
NC_020244:650109:6547726547726559681197Bacillus subtilis XF-1, complete genometerminase large subunit7e-0858.9
NC_009632:361229:3791313791313803391209Staphylococcus aureus subsp. aureus JH1 chromosome, completePBSX family phage terminase large subunit2e-0757
NC_009487:362475:3790613790613802691209Staphylococcus aureus subsp. aureus JH9 chromosome, completePBSX family phage terminase large subunit2e-0757
NC_017341:1976000:2002289200228920034971209Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,phage terminase, large subunit3e-0756.6
NC_015558:1813500:1818129181812918194391311Streptococcus parauberis KCTC 11537 chromosome, complete genomeputative terminase large subunit3e-0756.6
NC_018867:1837941:1849030184903018504901461Dehalobacter sp. CF chromosome, complete genomephage terminase, large subunit, PBSX family9e-0755.1
NC_018866:1790564:1819251181925118207111461Dehalobacter sp. DCA chromosome, complete genomephage terminase, large subunit, PBSX family9e-0755.1
NC_003212:57061:9360193601949321332Listeria innocua Clip11262, complete genomeputative terminase large subunit from Bacteriophage A1183e-0653.5
NC_021182:2536000:2555154255515425564251272Clostridium pasteurianum BC1, complete genomephage terminase, large subunit, PBSX family5e-0652.8