Pre_GI: BLASTP Hits

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Query: NC_009089:1093832:1112621 Clostridium difficile 630, complete genome

Start: 1112621, End: 1113313, Length: 693

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1683199:170360717036071704299693Clostridium difficile BI1, complete genomephage DNA-binding protein8e-121432
NC_013315:1679000:169559216955921696284693Clostridium difficile CD196 chromosome, complete genomephage DNA-binding protein8e-121432
NC_015519:1081539:109554310955431096265723Tepidanaerobacter sp. Re1 chromosome, complete genomephage protein8e-69259
NC_006322:1415863:144051014405101441217708Bacillus licheniformis ATCC 14580, complete genomeYqaS1e-54213
NC_006270:1415001:143964814396481440355708Bacillus licheniformis ATCC 14580, complete genomePutative DNA binding protein1e-54213
NC_014376:1472304:149144514914451492146702Clostridium saccharolyticum WM1 chromosome, complete genomephage protein5e-54210
NC_020244:650109:653955653955654686732Bacillus subtilis XF-1, complete genomeputative DNA binding protein5e-53207
NC_014976:627935:674526674526675245720Bacillus subtilis BSn5 chromosome, complete genomeputative phage-related terminase small subunit9e-53206
NC_014551:576000:595487595487596242756Bacillus amyloliquefaciens DSM 7, complete genomeyqaS; phage-related terminase small subunit9e-52203
NC_009617:1897887:191596319159631916745783Clostridium beijerinckii NCIMB 8052 chromosome, complete genomephage-related terminase small subunit-like protein2e-50199
NC_000964:2670288:268882026888202689539720Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein2e-50198
NC_017191:2223740:222932922293292230084756Bacillus amyloliquefaciens XH7 chromosome, complete genomeDNA binding protein3e-50198
NC_017188:2221705:222729422272942228049756Bacillus amyloliquefaciens TA208 chromosome, complete genomeyqaS; phage-related terminase small subunit3e-50198
NC_021171:254000:258661258661259392732Bacillus sp. 1NLA3E, complete genomeputative DNA binding protein2e-49195
NC_009706:2023912:203678020367802037562783Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein3e-49194
NC_021182:554000:571398571398572165768Clostridium pasteurianum BC1, complete genomehypothetical protein1e-48192
NC_020272:2748733:278156827815682782323756Bacillus amyloliquefaciens IT-45, complete genomeDNA binding protein2e-48192
NC_019842:1172944:119214811921481192897750Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,DNA binding protein9e-48189
NC_015275:986382:988314988314989030717Clostridium lentocellum DSM 5427 chromosome, complete genomePhage terminase small subunit2e-45182
NC_019896:1483073:153011915301191530892774Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completehypothetical protein1e-39162
NC_009633:2592000:261453926145392615393855Alkaliphilus metalliredigens QYMF chromosome, complete genomeYqaS4e-38157
NC_009848:2755874:277581927758192776463645Bacillus pumilus SAFR-032, complete genometerminase small subunit2e-35149
NC_003212:2413824:242798024279802428720741Listeria innocua Clip11262, complete genomehypothetical protein2e-31135
NC_013891:1639694:165301716530171653769753Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomephage-related terminase small subunit, putative1e-1583.2
NC_008497:1111891:111633811163381117096759Lactobacillus brevis ATCC 367, complete genomehypothetical protein1e-0756.6
NC_012658:1405788:141285914128591413359501Clostridium botulinum Ba4 str. 657 chromosome, complete genometerminase small subunit3e-0755.5
NC_009697:3110772:312695631269563127447492Clostridium botulinum A str. ATCC 19397 chromosome, completephage terminase small subunit2e-0652.4
NC_009495:2479465:250173525017352502586852Clostridium botulinum A str. ATCC 3502 chromosome, complete genomephage terminase small subunit5e-0651.6