Pre_GI: BLASTP Hits

Some Help

Query: NC_009089:1093832:1107557 Clostridium difficile 630, complete genome

Start: 1107557, End: 1108363, Length: 807

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia



SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_020244:650109:650109650109650933825Bacillus subtilis XF-1, complete genomehypothetical protein5e-56217
NC_020272:2748733:278646427864642787288825Bacillus amyloliquefaciens IT-45, complete genomemethyltransferase1e-55216
NC_020272:1311932:133077813307781331602825Bacillus amyloliquefaciens IT-45, complete genomemethyltransferase6e-55214
NC_012491:3736167:375185137518513752666816Brevibacillus brevis NBRC 100599, complete genomeputative methyltransferase4e-53208
NC_016894:3988180:399678039967803997607828Acetobacterium woodii DSM 1030 chromosome, complete genomephage-like N6 adenine-specific DNA methylase2e-50199
NC_014376:787460:815901815901816695795Clostridium saccharolyticum WM1 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase7e-49194
NC_003210:2380419:239181323918132392625813Listeria monocytogenes EGD-e, complete genomehypothetical protein5e-45181
NC_003212:57061:862908629087102813Listeria innocua Clip11262, complete genomehypothetical protein3e-45181
NC_009523:907775:920981920981921856876Roseiflexus sp. RS-1 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase4e-36151
NC_009656:4527457:458478545847854585675891Pseudomonas aeruginosa PA7 chromosome, complete genomeDNA adenine methyltransferase1e-33143
NC_018080:5091772:510590551059055106795891Pseudomonas aeruginosa DK2 chromosome, complete genomeDNA adenine methyltransferase2e-33142
NC_017167:1648913:170173717017371702615879Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1D12 class N6 adenine-specific DNA methyltransferase3e-32139
NC_013205:1187812:120609912060991206932834Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,D12 class N6 adenine-specific DNA methyltransferase3e-32138
NC_013720:5769910:579898757989875799883897Pirellula staleyi DSM 6068, complete genomeD12 class N6 adenine-specific DNA methyltransferase2e-31136
NC_012724:1892000:189367518936751894580906Burkholderia glumae BGR1 chromosome 1, complete genomeD12 class N6 adenine-specific DNA methyltransferase6e-31134
NC_013722:218847:222836222836223684849Xanthomonas albilineans, complete genomeputative n6 adenine-specific dna methyltransferase protein1e-29130
NC_010002:5143869:515492951549295155789861Delftia acidovorans SPH-1, complete genomeD12 class N6 adenine-specific DNA methyltransferase5e-27121
NC_013222:3098409:311612231161223116817696Robiginitalea biformata HTCC2501, complete genomeputative methyltransferase5e-27121
NC_014220:2037560:205483220548322055653822Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase6e-27121
NC_012779:3016327:303101830310183031824807Edwardsiella ictaluri 93-146, complete genomeDNA adenine methyltransferase9e-27120
NC_012808:3897751:3899875389987539014791605Methylobacterium extorquens AM1, complete genomeD12 class N6 adenine-specific DNA methyltransferase2e-25116
NC_012808:1979000:199122419912241992111888Methylobacterium extorquens AM1, complete genomeadenine-specific DNA methyltransferase2e-25116
NC_007907:2534462:254911925491192549703585Desulfitobacterium hafniense Y51, complete genomehypothetical protein3e-25115
NC_011206:1233985:124016812401681241058891Acidithiobacillus ferrooxidans ATCC 53993, complete genomeD12 class N6 adenine-specific DNA methyltransferase7e-25114
NC_011206:123791:128217128217129107891Acidithiobacillus ferrooxidans ATCC 53993, complete genomeD12 class N6 adenine-specific DNA methyltransferase7e-25114
NC_014836:1606587:1621088162108816221311044Desulfurispirillum indicum S5 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase2e-22105
NC_019842:1172944:118561811856181186442825Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,Site-specific DNA methylase1e-21103
NC_007963:1582089:158968915896891590450762Chromohalobacter salexigens DSM 3043, complete genomeDNA adenine methylase1e-1997.1
NC_012779:3016327:301769130176913018449759Edwardsiella ictaluri 93-146, complete genomeDNA adenine methylase1e-1996.7
NC_015666:3606053:363075136307513631614864Halopiger xanaduensis SH-6 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase2e-1996.3
NC_019792:153661:157406157406158293888Natronobacterium gregoryi SP2 chromosome, complete genomesite-specific DNA methylase2e-1995.9
NC_015850:1279372:129195212919521292872921Acidithiobacillus caldus SM-1 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase4e-1995.5
NC_012559:1663214:167124416712441672011768Laribacter hongkongensis HLHK9, complete genomeProbable methyltransferase5e-1995.1
NC_014483:3339926:336025233602523361064813Paenibacillus polymyxa E681 chromosome, complete genomeSite-specific DNA methylase5e-1995.1
NC_014972:2771902:278007427800742780835762Desulfobulbus propionicus DSM 2032 chromosome, complete genomeDNA adenine methylase2e-1892.8
NC_009615:1001744:100387710038771004686810Parabacteroides distasonis ATCC 8503 chromosome, complete genomemethyltransferase2e-1790.1
NC_019964:2080444:209454320945432095421879Halovivax ruber XH-70, complete genomesite-specific DNA methylase2e-1789.4
NC_012030:81837:104041104041104895855Halorubrum lacusprofundi ATCC 49239 plasmid pHLAC01, completeD12 class N6 adenine-specific DNA methyltransferase1e-1687.4
NC_013202:418500:445975445975446829855Halomicrobium mukohataei DSM 12286, complete genomeD12 class N6 adenine-specific DNA methyltransferase1e-1687
NC_015177:1131173:113249411324941133324831Pedobacter saltans DSM 12145 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase3e-1685.9
NC_015711:8964410:8979776897977689811281353Myxococcus fulvus HW-1 chromosome, complete genomen6 adenine-specific DNA methyltransferase1e-1583.6
NC_012724:2202173:221359022135902214381792Burkholderia glumae BGR1 chromosome 1, complete genomeGp2722e-1583.2
NC_012846:986877:102308310230831023868786Bartonella grahamii as4aup, complete genomeadenine-specific DNA methyltransferase2e-1582.8
NC_012846:986877:102167210216721022487816Bartonella grahamii as4aup, complete genomeadenine-specific DNA methyltransferase3e-1582.4
NC_007651:2166000:216831721683172169288972Burkholderia thailandensis E264 chromosome I, complete sequenceDNA adenine methylase9e-1580.9
NC_007434:1809946:181917118191711819959789Burkholderia pseudomallei 1710b chromosome I, complete sequencegp279e-1580.9
NC_014623:3199248:3199248319924832006001353Stigmatella aurantiaca DW4/3-1 chromosome, complete genomen6 adenine-specific DNA methyltransferase9e-1580.9
NC_014623:3097675:3097675309767530990271353Stigmatella aurantiaca DW4/3-1 chromosome, complete genomen6 adenine-specific DNA methyltransferase8e-1580.9
NC_009850:1651410:165650816565081657290783Arcobacter butzleri RM4018, complete genomeN6 adenine-specific DNA methyltransferase, D12 class2e-1479.7
NC_019903:1312843:131778013177801318712933Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,site-specific DNA methylase3e-1479.3
NC_010161:1914000:193310719331071933928822Bartonella tribocorum CIP 105476, complete genomephage-related modification methylase3e-1479
NC_010161:1949637:196911019691101969931822Bartonella tribocorum CIP 105476, complete genomephage-related modification methylase3e-1479
NC_010161:1324381:134371113437111344532822Bartonella tribocorum CIP 105476, complete genomephage-related modification methylase3e-1479
NC_002927:3827211:383460238346023835393792Bordetella bronchiseptica RB50, complete genomemodification methylase3e-1479
NC_015381:1202061:121846112184611219246786Burkholderia gladioli BSR3 chromosome 1, complete sequenceDNA adenine methylase5e-1478.6
NC_012724:3070386:308106930810693081809741Burkholderia glumae BGR1 chromosome 1, complete genomegp275e-1478.2
NC_019903:1345585:135280213528021353734933Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,site-specific DNA methylase6e-1478.2
NC_015381:3457784:347117134711713471956786Burkholderia gladioli BSR3 chromosome 1, complete sequencegp276e-1477.8
NC_015381:2109500:211653721165372117322786Burkholderia gladioli BSR3 chromosome 1, complete sequenceDNA adenine methylase7e-1477.8
NC_019903:1745849:175062817506281751566939Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,site-specific DNA methylase1e-1377
NC_015381:3091500:311175631117563112541786Burkholderia gladioli BSR3 chromosome 1, complete sequencegp271e-1377
NC_009706:1972000:197993219799321980759828Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein1e-1377
NC_009706:2023912:204826520482652049092828Clostridium kluyveri DSM 555 chromosome, complete genomeDNA methylase1e-1377
NC_011837:1969144:197976819797681980595828Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-1377
NC_021184:3571014:358577835857783586710933Desulfotomaculum gibsoniae DSM 7213, complete genomesite-specific DNA methylase4e-1375.1
NC_008390:2018201:203368920336892034477789Burkholderia cepacia AMMD chromosome 1, complete sequenceD12 class N6 adenine-specific DNA methyltransferase5e-1375.1
NC_010546:4923496:101041010411072969Cyanothece sp. ATCC 51142 chromosome circular, complete sequenceputative site-specific DNA-methyltransferase9e-1373.9
NC_018866:1402259:141263914126391413574936Dehalobacter sp. DCA chromosome, complete genomehypothetical protein1e-1273.9
NC_007907:5185510:519096951909695191904936Desulfitobacterium hafniense Y51, complete genomehypothetical protein1e-1273.9
NC_015160:937317:937317937317938159843Odoribacter splanchnicus DSM 20712 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase2e-1273.2
NC_005773:2177184:219452521945252195319795Pseudomonas syringae pv. phaseolicola 1448A, complete genomeprophage PSPPH02, putative adenine modification methytransferase4e-1272
NC_015856:1152021:117670911767091177263555Collimonas fungivorans Ter331 chromosome, complete genomeprophage PSPPH02 adenine modification methytransferase4e-1272
NC_007907:5297477:530299853029985303933936Desulfitobacterium hafniense Y51, complete genomehypothetical protein4e-1272
NC_020209:3262000:327234632723463273140795Pseudomonas poae RE*1-1-14, complete genomeD12 class N6 adenine-specific DNA methyltransferase1e-1170.5
NC_004578:3817330:383004238300423830836795Pseudomonas syringae pv. tomato str. DC3000, complete genomeDNA adenine methylase, putative1e-1170.5
NC_020301:669000:707879707879708697819Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomeadenine-specific DNA methyltransferase1e-1170.5
NC_005773:2177184:218385621838562184650795Pseudomonas syringae pv. phaseolicola 1448A, complete genomeprophage PSPPH02, putative adenine modification methytransferase1e-1170.1
NC_005773:5636606:565239656523965653190795Pseudomonas syringae pv. phaseolicola 1448A, complete genomeprophage PSPPH06, putative adenine modification methytransferase1e-1170.1
NC_010337:565730:580123580123581058936Heliobacterium modesticaldum Ice1, complete genomed12 class n6 adenine-specific DNA methyltransferase superfamily2e-1169.7
NC_016830:4999946:501431450143145015108795Pseudomonas fluorescens F113 chromosome, complete genomeprophage adenine modification methytransferase3e-1169.3
NC_007626:506532:5114845114845126501167Magnetospirillum magneticum AMB-1, complete genomeSite-specific DNA methylase3e-1168.9
NC_014376:3064787:307158830715883072409822Clostridium saccharolyticum WM1 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase3e-1168.9
NC_011837:3272752:328090132809013281734834Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-1168.6
NC_009706:3341250:334939933493993350232834Clostridium kluyveri DSM 555 chromosome, complete genomeDNA methylase4e-1168.6
NS_000195:526983:557966557966558742777Candidatus Cloacamonas acidaminovoransputative N6 adenine-specific DNA methyltransferase, D12 class6e-1168.2
NC_007494:739403:744384744384745190807Rhodobacter sphaeroides 2.4.1 chromosome 2, complete sequenceputative adenine-specific DNA methyltransferase5e-1168.2
NC_015733:1976752:198370119837011984471771Pseudomonas putida S16 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase8e-1167.8
NC_017986:4124335:413120141312014131971771Pseudomonas putida ND6 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase1e-1067
NC_007493:628243:646227646227647033807Rhodobacter sphaeroides 2.4.1 chromosome 1, complete sequenceN6 adenine-specific DNA methyltransferase, D12 class2e-1066.6
NC_011963:3073283:308649130864913087270780Rhodobacter sphaeroides KD131 chromosome 1, complete sequenceD12 class N6 adenine-specific DNA methyltransferase2e-1066.6
NC_007493:207932:223468223468224274807Rhodobacter sphaeroides 2.4.1 chromosome 1, complete sequencePutative N-6 adenine-specific DNA methylase2e-1066.6
NC_011958:923789:942015942015942821807Rhodobacter sphaeroides KD131 chromosome 2, complete genomeD12 class N6 adenine-specific DNA methyltransferase2e-1066.2
NC_009050:427000:427065427065427871807Rhodobacter sphaeroides ATCC 17029 chromosome 2, complete sequenceD12 class N6 adenine-specific DNA methyltransferase2e-1066.2
NC_011963:325806:341174341174341953780Rhodobacter sphaeroides KD131 chromosome 1, complete sequenceD12 class N6 adenine-specific DNA methyltransferase2e-1066.2
NS_000195:219785:239076239076239891816Candidatus Cloacamonas acidaminovoransN6 adenine-specific DNA methyltransferase, D12 class3e-1065.9
NC_011963:1482042:150132215013221502023702Rhodobacter sphaeroides KD131 chromosome 1, complete sequenceD12 class N6 adenine-specific DNA methyltransferase3e-1065.9
NS_000195:219785:238294238294239079786Candidatus Cloacamonas acidaminovoransputative N6 adenine-specific DNA methyltransferase, D12 class3e-1065.5
NC_007494:867901:889223889223890029807Rhodobacter sphaeroides 2.4.1 chromosome 2, complete sequenceAdenine-specific DNA methyltransferase6e-1064.7
NS_000195:526983:557148557148557969822Candidatus Cloacamonas acidaminovoransputative N6 adenine-specific DNA methyltransferase, D12 class1e-0963.9
NC_009437:685214:702936702936703808873Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeDNA adenine methylase2e-0962.8
NC_018870:484000:501570501570502397828Thermacetogenium phaeum DSM 12270 chromosome, complete genomeDNA adenine methylase Dam3e-0962.4
NC_014931:4490526:449619444961944497003810Variovorax paradoxus EPS chromosome, complete genomeDNA adenine methylase1e-0860.8
NC_014364:2111685:212945021294502129836387Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase1e-0860.1
NC_019904:1616742:162405716240571624908852Echinicola vietnamensis DSM 17526 chromosome, complete genomeDNA adenine methylase Dam1e-0860.1
NC_007908:1946902:195719019571901958011822Rhodoferax ferrireducens T118, complete genomeDNA adenine methylase3e-0859.3
NC_009051:1455183:147118414711841472035852Methanoculleus marisnigri JR1, complete genomeDNA adenine methylase6e-0858.2
NC_015573:2463123:247378724737872474626840Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomeDNA adenine methylase8e-0857.8
NC_014910:3727887:374454637445463745481936Alicycliphilus denitrificans BC chromosome, complete genomeDNA adenine methylase1e-0757.4
NC_021184:3497000:350319535031953503812618Desulfotomaculum gibsoniae DSM 7213, complete genomesite-specific DNA methylase2e-0756.6
NC_012724:1308000:131762613176261317976351Burkholderia glumae BGR1 chromosome 1, complete genomeD12 class N6 adenine-specific DNA methyltransferase2e-0756.2
NC_010793:1922000:192615419261541926963810Orientia tsutsugamushi str. Ikeda, complete genomeN6 adenine-specific DNA-methyltransferase3e-0755.8
NC_007963:1552761:156348015634801564292813Chromohalobacter salexigens DSM 3043, complete genomeDNA adenine methylase3e-0755.8
NC_009012:2927793:294181129418112942653843Clostridium thermocellum ATCC 27405, complete genomeDNA adenine methylase3e-0755.8
NC_007517:3524715:3535829353582935377451917Geobacter metallireducens GS-15, complete genomeDNA adenine methylase5e-0755.1
NC_008497:32160:4830348303493281026Lactobacillus brevis ATCC 367, complete genomeSite-specific DNA methylase5e-0755.1
NC_009659:3815966:3825792382579238276961905Janthinobacterium sp. Marseille chromosome, complete genomeDNA adenine methylase7e-0754.7
NC_009328:2161116:217781121778112178653843Geobacillus thermodenitrificans NG80-2 chromosome, complete genomeadenine-specific DNA methyltransferase1e-0653.9
NC_004557:363628:380624380624381466843Clostridium tetani E88, complete genomeputative adenine-specific DNA methyltransferase2e-0653.5
NC_015510:2907815:292062329206232921420798Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomeDNA adenine methylase6e-0651.6
NC_014751:946155:968124968124968900777Mycoplasma leachii PG50 chromosome, complete genomeDNA adenine methylase6e-0651.6
NC_015177:1131173:115688111568811157648768Pedobacter saltans DSM 12145 chromosome, complete genomeD12 class N6 adenine-specific DNA methyltransferase7e-0651.2
NC_012778:1819559:182985418298541830735882Eubacterium eligens ATCC 27750, complete genomesite-specific DNA-methyltransferase (adenine-specific)7e-0651.2