Pre_GI: BLASTP Hits

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Query: NC_009089:1093832:1105182 Clostridium difficile 630, complete genome

Start: 1105182, End: 1105907, Length: 726

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009089:1093832:10873831087383114439857016Clostridium difficile 630, complete genome5e-136483
NC_004668:2198027:225599522559952256852858Enterococcus faecalis V583, complete genomehypothetical protein3e-1892
NC_015573:569625:581582581582582421840Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomephosphoadenosine phosphosulfate reductase4e-1581.6
NC_018870:1695588:171869017186901719511822Thermacetogenium phaeum DSM 12270 chromosome, complete genomephosphoadenosine phosphosulfate reductase3e-1479
NC_013887:407771:4259364259364273601425Methanocaldococcus sp. FS406-22 chromosome, complete genomephosphoadenosine phosphosulfate reductase3e-1375.5
NC_013156:381910:4032834032834047071425Methanocaldococcus fervens AG86, complete genomephosphoadenosine phosphosulfate reductase2e-1169.7
NC_016631:4113794:415525841552584156064807Granulicella mallensis MP5ACTX8 chromosome, complete genomephosphoadenosine phosphosulfate reductase2e-1169.3
NC_014253:142026:1543271543271554601134Methanohalobium evestigatum Z-7303 chromosome, complete genomephosphoadenosine phosphosulfate reductase5e-1168.2
NC_015564:2870631:288979428897942890648855Amycolicicoccus subflavus DQS3-9A1 chromosome, complete genomephosphoadenosine phosphosulfate reductase7e-1167.4
NC_008596:1302000:132023013202301321078849Mycobacterium smegmatis str. MC2 155, complete genomephosphoadenosine phosphosulfate reductase1e-1067
NC_009975:917337:9382089382089394941287Methanococcus maripaludis C6, complete genomephosphoadenosine phosphosulfate reductase2e-1066.2
NC_016613:1159980:116244411624441163343900Vibrio sp. EJY3 chromosome 1, complete sequencephage-like protein2e-1066.2
NC_017059:2491924:250410125041012504919819Rhodospirillum photometricum DSM 122, complete genomephosphoadenosine phosphosulfate reductase3e-1065.5
NC_009135:1654131:1675813167581316770991287Methanococcus maripaludis C5, complete genomephosphoadenosine phosphosulfate reductase8e-1064.3
NC_014820:582443:624061624061624900840Cenarchaeum symbiosum A, complete genome3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase1e-0963.5
NC_013956:595320:607501607501608343843Pantoea ananatis LMG 20103 chromosome, complete genomehypothetical protein1e-0963.2
NC_014820:582443:595773595773596612840Cenarchaeum symbiosum A, complete genome3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase2e-0962.8
NC_013929:3722867:375552737555273756360834Streptomyces scabiei 87.22 chromosome, complete genomehypothetical protein5e-0961.6
NC_009051:1118486:1137103113710311385121410Methanoculleus marisnigri JR1, complete genomephosphoadenosine phosphosulfate reductase7e-0961.2
NC_014394:738365:738365738365739207843Gallionella capsiferriformans ES-2 chromosome, complete genomephosphoadenosine phosphosulfate reductase1e-0860.5
NC_013093:626473:648541648541649371831Actinosynnema mirum DSM 43827, complete genomephosphoadenosine phosphosulfate reductase3e-0859.3
NC_004547:3207776:322053232205323221371840Erwinia carotovora subsp. atroseptica SCRI1043, complete genomeputative phage-related protein4e-0858.5
NC_014222:1437672:1440138144013814418111674Methanococcus voltae A3 chromosome, complete genomephosphoadenosine phosphosulfate reductase4e-0858.5
NC_016051:1803880:1824817182481718259501134Thermococcus sp. AM4 chromosome, complete genomeiron-sulfur protein5e-0858.2
NC_008758:143907:151744151744152583840Polaromonas naphthalenivorans CJ2 plasmid pPNAP02, completephosphoadenosine phosphosulfate reductase7e-0857.8
NC_011205:609464:631775631775632647873Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853phosphoadenosine phosphosulfate reductase family protein1e-0757
NC_011750:5045927:505556150555615056439879Escherichia coli IAI39 chromosome, complete genomeputative phosphoadenosine phosphosulfate reductase from phage origin4e-0755.1
NC_006905:368942:388012388012388884873Salmonella enterica subsp. enterica serovar Choleraesuis strNin-like protein4e-0755.1
NC_012759:4132527:414666441466644147554891Escherichia coli BW2952 chromosome, complete genomeNin-like protein5e-0754.7
NC_013595:9547254:957306895730689573904837Streptosporangium roseum DSM 43021, complete genomephosphoadenosine phosphosulfate reductase1e-0653.9
NC_008825:1258500:126842712684271269269843Methylibium petroleiphilum PM1, complete genomeputative phage-related protein3e-0652.4
NC_013282:1200993:120867112086711209540870Cronobacter turicensis, complete genomeUncharacterized nin region protein ORF2906e-0651.2
NC_015865:3657:4615346153480481896Thermococcus sp. 4557 chromosome, complete genomehypothetical protein6e-0651.2