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Query: NC_009089:1093832:1104178 Clostridium difficile 630, complete genome

Start: 1104178, End: 1105173, Length: 996

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1133510:1144977114497711459811005Clostridium difficile BI1, complete genomehypothetical protein6e-121434
NC_009699:2552195:2558468255846825594931026Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-39162
NC_012658:1405788:1408652140865214097011050Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-31137
NC_009697:2558286:2583575258357525846241050Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein8e-30131
NC_016012:1312352:1329789132978913308231035Candidatus Arthromitus sp. SFB-rat-Yit, complete genomehypothetical protein4e-2099
NC_017297:2531750:2558608255860825596331026Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-39162
NC_010516:2676746:2701931270193127029801050Clostridium botulinum B1 str. Okra, complete genomehypothetical protein5e-32138
NC_012563:1681639:1696913169691316979621050Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein3e-31135
NC_015913:1422444:1439899143989914409211023Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomehypothetical protein6e-22105
NC_020291:5808856:5830296583029658313331038Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein1e-34147
NC_009699:3429817:3453755345375534548041050Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-31137
NC_017294:1385576:1406295140629514073321038Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomehypothetical protein5e-22105
NC_014614:2333890:2353835235383523548511017Clostridium sticklandii, complete genomehypothetical protein4e-0859.3
NC_013315:1123733:1135200113520011362041005Clostridium difficile CD196 chromosome, complete genomehypothetical protein6e-121434
NC_012563:2680246:2686417268641726874421026Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein6e-39161
NC_017297:3428429:3452369345236934534181050Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-31137
NC_010418:188138:2012522012522022771026Clostridium botulinum A3 str. Loch Maree plasmid pCLK, completehypothetical protein1e-26120
NC_016894:3329562:3335424333542433364311008Acetobacterium woodii DSM 1030 chromosome, complete genomehypothetical protein5e-1168.9
NC_016627:3659500:3660568366056836615931026Clostridium clariflavum DSM 19732 chromosome, complete genomenucleoid-associated protein1e-44180