Pre_GI: BLASTP Hits

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Query: NC_009089:1093832:1097768 Clostridium difficile 630, complete genome

Start: 1097768, End: 1098283, Length: 516

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009706:3341250:335375833537583354246489Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein3e-1064.3
NC_009800:289000:296307296307296666360Escherichia coli HS, complete genomehypothetical protein8e-0753.1
NC_014925:578759:589478589478589963486Staphylococcus pseudintermedius HKU10-03 chromosome, completehypothetical protein2e-0652
NC_004129:4368356:438674843867484387281534Pseudomonas fluorescens Pf-5, complete genomehypothetical protein4e-0650.8
NC_011837:3272752:328526032852603285748489Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-1064.3
NC_009641:1105075:110507511050751105554480Staphylococcus aureus subsp. aureus str. Newman chromosome,hypothetical protein2e-0652
NC_010610:535790:543201543201543686486Lactobacillus fermentum IFO 3956, complete genomehypothetical protein4e-0650.8
NC_008555:1204000:121776512177651218244480Listeria welshimeri serovar 6b str. SLCC5334, complete genomehypothetical protein1e-0859.3
NC_008258:269806:282426282426282908483Shigella flexneri 5 str. 8401, complete genomehypothetical protein1e-0652.4
NC_010371:57683:629196291963455537Finegoldia magna ATCC 29328 plasmid pFMC, complete sequencehypothetical protein4e-0650.8
NC_002927:3716894:375919237591923759698507Bordetella bronchiseptica RB50, complete genomehypothetical protein3e-0961.2
NC_017328:303987:314367314367314807441Shigella flexneri 2002017 chromosome, complete genomehypothetical protein1e-0652.8
NC_013450:854790:862162862162862641480Staphylococcus aureus subsp. aureus ED98, complete genomehypothetical protein4e-0650.8
NC_003212:2293425:231435323143532314829477Listeria innocua Clip11262, complete genomehypothetical protein7e-0650.1
NC_017353:887581:895261895261895746486Staphylococcus lugdunensis N920143, complete genomesiphovirus Gp157 family protein5e-0857.4