Pre_GI: BLASTP Hits

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Query: NC_009089:1093832:1093832 Clostridium difficile 630, complete genome

Start: 1093832, End: 1094164, Length: 333

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1683199:168719916871991687747549Clostridium difficile BI1, complete genomephage regulatory protein1e-21102
NC_014964:2272413:229248922924892292878390Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completehelix-turn-helix domain-containing protein7e-1269.3
NC_009633:2592000:263151726315172631879363Alkaliphilus metalliredigens QYMF chromosome, complete genomehelix-turn-helix domain-containing protein1e-1168.6
NC_015573:2040500:204189420418942042295402Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomehelix-turn-helix domain-containing protein2e-1168.2
NC_003212:57061:785057850578981477Listeria innocua Clip11262, complete genomehypothetical protein1e-1065.5
NC_014538:2158131:218091821809182181331414Thermoanaerobacter sp. X513 chromosome, complete genomehelix-turn-helix domain-containing protein1e-1065.1
NC_014964:35862:358623586236251390Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completehelix-turn-helix domain-containing protein8e-1062.4
NC_010321:35855:358553585536244390Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeXRE family transcriptional regulator8e-1062.4
NC_015601:627217:628845628845629261417Erysipelothrix rhusiopathiae str. Fujisawa, complete genomeXRE family transcriptional regulator1e-0962
NC_015519:1081539:108566910856691086064396Tepidanaerobacter sp. Re1 chromosome, complete genomehelix-turn-helix domain-containing protein1e-0961.6
NC_015428:1483768:150354015035401503917378Lactobacillus buchneri NRRL B-30929 chromosome, complete genomehelix-turn-helix domain-containing protein1e-0961.6
NC_013892:1272448:128399912839991284364366Xenorhabdus bovienii SS-2004 chromosome, complete genomeDNA-binding protein2e-0961.6
NC_011837:3272752:329170232917023292304603Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-0961.6
NC_009706:3341250:336020033602003360802603Clostridium kluyveri DSM 555 chromosome, complete genometranscriptional regulator2e-0961.6
NC_014657:2127500:214037221403722140905534Caldicellulosiruptor owensensis OL chromosome, complete genomehelix-turn-helix domain protein5e-0959.7
NC_009495:2479465:252016025201602520594435Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeDNA-binding phage protein5e-0959.7
NC_012034:2555447:257988525798852580199315Anaerocellum thermophilum DSM 6725, complete genometranscriptional regulator, XRE family7e-0959.3
NC_011660:2924397:292631729263172926793477Listeria monocytogenes HCC23 chromosome, complete genomegp338e-0959.3
NC_021175:2063611:207187220718722072216345Streptococcus oligofermentans AS 1.3089, complete genomeCro/CI family transcriptional regulator8e-0958.9
NC_013205:526281:535213535213535704492Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,transcriptional regulator, XRE family2e-0858.2
NC_000964:521975:530691530691531074384Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein2e-0857.8
NC_009513:870837:873129873129873464336Lactobacillus reuteri F275, complete genometranscriptional regulator, XRE family2e-0857.8
NC_010516:2328288:234697823469782347427450Clostridium botulinum B1 str. Okra, complete genometranscriptional regulator2e-0857.8
NC_010610:755000:763466763466763780315Lactobacillus fermentum IFO 3956, complete genomehypothetical protein2e-0857.4
NC_008526:1924761:194300319430031943248246Lactobacillus casei ATCC 334, complete genomeTranscriptional regulator, xre family4e-0856.6
NC_010999:1245239:125530312553031255641339Lactobacillus casei, complete genomeRepressor (Gp132 protein)6e-0856.2
NC_013198:1095591:110846011084601108798339Lactobacillus rhamnosus GG, complete genomeprophage protein, DNA-binding protein1e-0755.1
NC_012658:1810640:181110518111051811530426Clostridium botulinum Ba4 str. 657 chromosome, complete genomeimmunity repressor protein1e-0755.1
NC_013798:1778758:179057017905701790932363Streptococcus gallolyticus UCN34, complete genomeputative transcriptional regulator, Cro/CI family1e-0755.1
NC_009706:1972000:199149419914941992135642Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein1e-0755.1
NC_013921:1915377:192814219281421928690549Thermoanaerobacter italicus Ab9 chromosome, complete genometranscriptional regulator, XRE family2e-0754.7
NC_006270:1415001:142528614252861425654369Bacillus licheniformis ATCC 14580, complete genomeprobable transcriptional regulator (phage-related)2e-0754.7
NC_006322:1415863:142614914261491426517369Bacillus licheniformis ATCC 14580, complete genomeYqaE2e-0754.7
NC_003919:1716831:172547517254751725804330Xanthomonas axonopodis pv. citri str. 306, complete genometranscriptional regulator2e-0754.3
NC_016894:3988180:400563340056334006028396Acetobacterium woodii DSM 1030 chromosome, complete genomeputative phage repressor3e-0753.9
NC_013205:526281:537615537615537833219Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,plasmid maintenance system antidote protein, XRE family4e-0753.5
NC_015958:2174731:218947921894792190027549Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehelix-turn-helix domain-containing protein4e-0753.5
NC_014319:587977:593128593128593592465Leuconostoc gasicomitatum LMG 18811, complete genomePbsX transcriptional repressor4e-0753.5
NC_017025:1651870:166594816659481666286339Flavobacterium indicum GPTSA100-9, complete genometranscriptional regulator, XRE family4e-0753.5
NC_004129:195347:205065205065205427363Pseudomonas fluorescens Pf-5, complete genomeDNA-binding protein, putative6e-0752.8
NC_014759:4133809:415013541501354150905771Marivirga tractuosa DSM 4126 chromosome, complete genomehelix-turn-helix domain protein7e-0752.8
NC_010001:649000:650678650678651022345Clostridium phytofermentans ISDg, complete genometranscriptional regulator, XRE family9e-0752.4
NC_021182:4367736:438581243858124386150339Clostridium pasteurianum BC1, complete genomeputative transcriptional regulator8e-0752.4
NC_007644:280000:287262287262287648387Moorella thermoacetica ATCC 39073, complete genometranscriptional regulator, XRE family8e-0752.4
NC_014551:576000:577723577723578103381Bacillus amyloliquefaciens DSM 7, complete genomehypothetical protein1e-0652
NC_009328:293000:362637362637363419783Geobacillus thermodenitrificans NG80-2 chromosome, complete genomehypothetical protein2e-0651.2
NC_015573:2463123:248662424866242486842219Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomehelix-turn-helix domain-containing protein2e-0651.2
NC_003212:1248000:124920512492051249633429Listeria innocua Clip11262, complete genomehypothetical protein2e-0651.2
NC_015875:190041:192949192949193464516Streptococcus pseudopneumoniae IS7493 chromosome, complete genomeXRE family transcriptional regulator2e-0651.2
NC_016077:1278104:129394612939461294317372Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein3e-0650.8
NC_020291:795500:818708818708819061354Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative transcriptional regulator2e-0650.8
NC_010001:69000:909309093091751822Clostridium phytofermentans ISDg, complete genometranscriptional regulator, XRE family2e-0650.8
NC_015977:3011177:302804130280413028793753Roseburia hominis A2-183 chromosome, complete genomehypothetical protein3e-0650.4
NC_015732:982774:9996799996791000284606Spirochaeta caldaria DSM 7334 chromosome, complete genomehelix-turn-helix domain-containing protein4e-0650.4
NC_016048:751000:769269769269769643375Oscillibacter valericigenes Sjm18-20, complete genomeputative Xre family DNA-binding protein5e-0650.1
NC_009633:168266:191711191711192133423Alkaliphilus metalliredigens QYMF chromosome, complete genomeXRE family transcriptional regulator6e-0649.7
NC_017068:1852708:191313019131301913660531Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative Xre family transcriptional regulator6e-0649.7
NC_014479:509919:530075530075530860786Bacillus subtilis subsp. spizizenii str. W23 chromosome, completehelix-turn-helix domain-containing protein7e-0649.3
NC_016510:2312481:232574323257432326075333Flavobacterium columnare ATCC 49512 chromosome, complete genomehelix-turN-helix domain protein8e-0648.9