Query: NC_008593:1461771 Clostridium novyi NT, complete genome
Start: 1461771, End: 1484982, Length: 23212
Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria
General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.
Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!
Subject Island | Start | End | Length | Subject Host Description | E-value | Bit score | Visual BLASTN | Visual BLASTP |
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NC_014328:1307490* | 1307490 | 1331216 | 23727 | Clostridium ljungdahlii ATCC 49587 chromosome, complete genome | 9e-105 | 389 | BLASTN svg | BLASTP svg |
NC_003030:1811820* | 1811820 | 1835053 | 23234 | Clostridium acetobutylicum ATCC 824, complete genome | 3e-98 | 367 | BLASTN svg | BLASTP svg |
NC_021182:2422226* | 2422226 | 2447353 | 25128 | Clostridium pasteurianum BC1, complete genome | 3e-86 | 327 | BLASTN svg | BLASTP svg |
NC_003366:2057656* | 2057656 | 2082099 | 24444 | Clostridium perfringens str. 13, complete genome | 4e-64 | 254 | BLASTN svg | BLASTP svg |
NC_008262:1950205* | 1950205 | 1969678 | 19474 | Clostridium perfringens SM101, complete genome | 2e-62 | 248 | BLASTN svg | BLASTP svg |
NC_015687:1811573* | 1811573 | 1834638 | 23066 | Clostridium acetobutylicum DSM 1731 chromosome, complete genome | 7e-44 | 186 | BLASTN svg | BLASTP svg |
NC_006831:622906 | 622906 | 647329 | 24424 | Ehrlichia ruminantium str. Gardel, complete genome | 2e-16 | 95.6 | BLASTN svg | BLASTP svg |
NC_006832:627057 | 627057 | 651669 | 24613 | Ehrlichia ruminantium str. Welgevonden, complete genome | 2e-16 | 95.6 | BLASTN svg | BLASTP svg |
NC_005295:647275 | 647275 | 671824 | 24550 | Ehrlichia ruminantium str. Welgevonden, complete genome | 2e-16 | 95.6 | BLASTN svg | BLASTP svg |
NC_014720:1161841* | 1161841 | 1181484 | 19644 | Caldicellulosiruptor kronotskyensis 2002 chromosome, complete | 5e-14 | 87.7 | BLASTN svg | BLASTP svg |
NC_004193:375416* | 375416 | 683449 | 308034 | Oceanobacillus iheyensis HTE831, complete genome | 2e-13 | 85.7 | BLASTN svg | BLASTP svg |
NC_003454:1346500* | 1346500 | 1365862 | 19363 | Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete | 7e-13 | 83.8 | BLASTN svg | BLASTP svg |
NC_014657:673500* | 673500 | 694314 | 20815 | Caldicellulosiruptor owensensis OL chromosome, complete genome | 1e-11 | 79.8 | BLASTN svg | BLASTP svg |
NC_002952:1291444* | 1291444 | 1314909 | 23466 | Staphylococcus aureus subsp. aureus MRSA252, complete genome | 7e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_014377:1089894* | 1089894 | 1109099 | 19206 | Thermosediminibacter oceani DSM 16646 chromosome, complete genome | 7e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_015949:1180755* | 1180755 | 1216930 | 36176 | Caldicellulosiruptor lactoaceticus 6A chromosome, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_014721:1777644* | 1777644 | 1816005 | 38362 | Caldicellulosiruptor kristjanssonii 177R1B chromosome, complete | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_014657:1193985* | 1193985 | 1215351 | 21367 | Caldicellulosiruptor owensensis OL chromosome, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_014652:1032711* | 1032711 | 1073951 | 41241 | Caldicellulosiruptor hydrothermalis 108 chromosome, complete | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_012034:1783912* | 1783912 | 1823670 | 39759 | Anaerocellum thermophilum DSM 6725, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_009437:2367842* | 2367842 | 2411500 | 43659 | Caldicellulosiruptor saccharolyticus DSM 8903, complete genome | 3e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_013517:2633574* | 2633574 | 2656132 | 22559 | Sebaldella termitidis ATCC 33386, complete genome | 1e-08 | 69.9 | BLASTN svg | BLASTP svg |
NC_019978:2036779* | 2036779 | 2059290 | 22512 | Halobacteroides halobius DSM 5150, complete genome | 1e-08 | 69.9 | BLASTN svg | BLASTP svg |
NC_016012:805680* | 805680 | 827841 | 22162 | Candidatus Arthromitus sp. SFB-rat-Yit, complete genome | 2e-07 | 65.9 | BLASTN svg | BLASTP svg |
NC_011772:4321117* | 4321117 | 4339226 | 18110 | Bacillus cereus G9842, complete genome | 2e-07 | 65.9 | BLASTN svg | BLASTP svg |
NC_009782:1327340* | 1327340 | 1350800 | 23461 | Staphylococcus aureus subsp. aureus Mu3, complete genome | 2e-07 | 65.9 | BLASTN svg | BLASTP svg |
NC_014150:1304573* | 1304573 | 1324439 | 19867 | Brachyspira murdochii DSM 12563 chromosome, complete genome | 7e-07 | 63.9 | BLASTN svg | BLASTP svg |
NC_013515:347671* | 347671 | 396366 | 48696 | Streptobacillus moniliformis DSM 12112, complete genome | 7e-07 | 63.9 | BLASTN svg | BLASTP svg |
NC_010830:923266 | 923266 | 945017 | 21752 | Candidatus Amoebophilus asiaticus 5a2, complete genome | 3e-06 | 61.9 | BLASTN svg | BLASTP svg |