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Query: NC_008593:609723:621356 Clostridium novyi NT, complete genome

Start: 621356, End: 626383, Length: 5028

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:609723:6185476185476212672721Clostridium novyi NT, complete genomeLeucine Rich Repeat domain protein6e-96353
NC_015425:641000:6498396498396525142676Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein1e-58229
NC_015425:641000:652519652519653220702Clostridium botulinum BKT015925 chromosome, complete genomeNPQTN cell wall surface anchor protein4e-1895.1
NC_015425:641000:647695647695648672978Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein3e-1172
NC_015425:641000:6486836486836498281146Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein3e-1068.9
NC_013929:3953046:396206539620653962988924Streptomyces scabiei 87.22 chromosome, complete genomehypothetical protein9e-1067.4
NC_007645:3227098:3234861323486132358651005Hahella chejuensis KCTC 2396, complete genomeLeucine-rich repeat (LRR) protein1e-0967
NC_007645:3630884:3656391365639136575031113Hahella chejuensis KCTC 2396, complete genomeLeucine-rich repeat (LRR) protein2e-0862.8
NC_015572:2186394:2214273221427322157871515Methylomonas methanica MC09 chromosome, complete genomeadenylate cyclase1e-0760.5
NC_007969:1095438:1113443111344311155842142Psychrobacter cryohalolentis K5, complete genomeLeucine-rich repeat, typical subtype3e-0758.9
NC_015376:2010009:2029236202923620305641329Burkholderia gladioli BSR3 chromosome chromosome 2, completeProtein kinase4e-0758.5
NC_007645:3227098:323749232374923238484993Hahella chejuensis KCTC 2396, complete genomeLeucine-rich repeat (LRR) protein6e-0758.2
NC_015167:1911758:1920276192027619217361461Cellulophaga lytica DSM 7489 chromosome, complete genomeleucine-rich repeat-containing protein1e-0657
NC_015761:1181186:1188971118897111914122442Salmonella bongori NCTC 12419, complete genomeleucine rich repeat virulence protein2e-0656.6
NC_015172:1471501:14866231486623149964213020Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomecell wall binding repeat 2-containing protein2e-0656.2
NC_007645:6647500:665151766515176652437921Hahella chejuensis KCTC 2396, complete genomeLeucine-rich repeat (LRR) protein4e-0655.5
NC_017243:1197586:120840812084081209286879Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein5e-0655.1
NC_015578:3694813:3706705370670537081081404Treponema primitia ZAS-2 chromosome, complete genomeadenylate cyclase6e-0654.7