Pre_GI: BLASTP Hits

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Query: NC_008593:609723:618547 Clostridium novyi NT, complete genome

Start: 618547, End: 621267, Length: 2721

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:609723:6213566213566263835028Clostridium novyi NT, complete genomehypothetical protein7e-93342
NC_015425:641000:647695647695648672978Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein3e-34147
NC_015425:641000:6486836486836498281146Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein1e-33145
NC_015425:641000:6498396498396525142676Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein1e-24115
NC_007645:3227098:3234861323486132358651005Hahella chejuensis KCTC 2396, complete genomeLeucine-rich repeat (LRR) protein8e-1480.1
NC_015572:2186394:2214273221427322157871515Methylomonas methanica MC09 chromosome, complete genomeadenylate cyclase8e-1376.6
NC_015172:1471501:14866231486623149964213020Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomecell wall binding repeat 2-containing protein1e-1172.4
NC_007645:3630884:3656391365639136575031113Hahella chejuensis KCTC 2396, complete genomeLeucine-rich repeat (LRR) protein2e-1172.4
NC_015578:3694813:3706705370670537081081404Treponema primitia ZAS-2 chromosome, complete genomeadenylate cyclase4e-1170.9
NC_015425:641000:652519652519653220702Clostridium botulinum BKT015925 chromosome, complete genomeNPQTN cell wall surface anchor protein2e-1068.6
NC_007969:1095438:1113443111344311155842142Psychrobacter cryohalolentis K5, complete genomeLeucine-rich repeat, typical subtype2e-1068.6
NC_013929:3953046:396206539620653962988924Streptomyces scabiei 87.22 chromosome, complete genomehypothetical protein1e-0965.9
NC_007969:1095438:1110881111088111131542274Psychrobacter cryohalolentis K5, complete genomeLeucine-rich repeat, typical subtype1e-0965.9
NC_007645:3227098:323749232374923238484993Hahella chejuensis KCTC 2396, complete genomeLeucine-rich repeat (LRR) protein2e-0965.1
NC_017243:1197586:120840812084081209286879Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein4e-0964.3
NC_015578:2341026:2358771235877123611882418Treponema primitia ZAS-2 chromosome, complete genomeleucine Rich Repeat domain-containing protein5e-0963.9
NC_015761:1181186:1188971118897111914122442Salmonella bongori NCTC 12419, complete genomeleucine rich repeat virulence protein5e-0963.9
NC_015376:2010009:2029236202923620305641329Burkholderia gladioli BSR3 chromosome chromosome 2, completeProtein kinase9e-0963.2
NC_015578:3495034:3511948351194835136601713Treponema primitia ZAS-2 chromosome, complete genomesmall GTP-binding protein1e-0862.8
NC_007645:6647500:665151766515176652437921Hahella chejuensis KCTC 2396, complete genomeLeucine-rich repeat (LRR) protein3e-0861.2
NC_009348:1968826:1980504198050419818771374Aeromonas salmonicida subsp. salmonicida A449, complete genomeSerine/threonine protein kinase4e-0861.2
NC_015424:2510764:2514813251481325161831371Aeromonas veronii B565 chromosome, complete genomeserine/threonine protein kinase5e-0860.5
NC_012225:2198987:221784722178472218446600Brachyspira hyodysenteriae WA1, complete genomeputative leucine rich repeat protein1e-0759.3
NC_007969:2885249:289061228906122891502891Psychrobacter cryohalolentis K5, complete genomeleucine-rich repeat3e-0758.2
NS_000195:219785:21978521978523012210338Candidatus Cloacamonas acidaminovoransputative Phosphoprotein phosphatase7e-0757
NC_003366:255480:2910562910562932872232Clostridium perfringens str. 13, complete genomehypothetical protein2e-0655.8
NC_008150:3711953:3723173372317337250531881Yersinia pestis Antiqua, complete genomeputative antigenic leucine-rich repeat protein2e-0655.8
NC_008149:3648139:3669702366970236715821881Yersinia pestis Nepal516, complete genomeantigenic leucine-rich repeat protein2e-0655.8
NC_017168:4509918:4526115452611545279951881Yersinia pestis A1122 chromosome, complete genomeputative antigenic leucine-rich repeat protein2e-0655.8
NC_017154:848500:8700868700868719331848Yersinia pestis D106004 chromosome, complete genomeantigenic leucine-rich repeat protein2e-0655.8
NC_010465:804249:8173048173048191721869Yersinia pseudotuberculosis YPIII, complete genomeputative antigenic leucine-rich repeat protein3e-0654.7
NC_008262:227354:2628832628832651142232Clostridium perfringens SM101, complete genomeLPXTG-motif cell wall anchor domain protein4e-0654.3
NC_012488:349862:3604113604113657385328Listeria monocytogenes Clip81459, complete genomeinternalin proteins, peptidoglycan bound protein (LPXTG motif)8e-0653.1
NC_015167:1911758:1920276192027619217361461Cellulophaga lytica DSM 7489 chromosome, complete genomeleucine-rich repeat-containing protein9e-0653.1