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Query: NC_008593:609723:616718 Clostridium novyi NT, complete genome

Start: 616718, End: 617200, Length: 483

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014171:4708282:473116047311604731657498Bacillus thuringiensis BMB171 chromosome, complete genomeAsnC family transcriptional regulator5e-36150
NC_017208:4845281:486722148672214867718498Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeAsnC family transcriptional regulator5e-36150
NC_009617:4761000:477468747746874775166480Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeAsnC family transcriptional regulator7e-63239
NC_006396:1097000:111935011193501119844495Haloarcula marismortui ATCC 43049 chromosome I, complete sequenceleucine responsive regulatory protein2e-22104
NC_018868:282738:300482300482300970489Simiduia agarivorans SA1 = DSM 21679 chromosome, complete genomeleucine-responsive transcriptional regulator5e-0753.5
NC_020291:1810527:181602818160281816507480Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genometranscriptional regulator, AsnC family1e-64244
NC_008262:784878:820431820431820913483Clostridium perfringens SM101, complete genometranscriptional regulator, AsnC family5e-63239
NC_013741:424278:425724425724426212489Archaeoglobus profundus DSM 5631, complete genometranscriptional regulator, AsnC family3e-31134
NC_010995:20181:455864558646134549Cellvibrio japonicus Ueda107, complete genometranscriptional regulator, AsnC family6e-0960.1
NC_013926:614206:633121633121633582462Aciduliprofundum boonei T469 chromosome, complete genometranscriptional regulator, AsnC family8e-0649.7
NC_008261:817295:840440840440840922483Clostridium perfringens ATCC 13124, complete genometranscriptional regulator, AsnC family5e-63239
NC_009831:5107924:510792451079245108403480Shewanella sediminis HAW-EB3, complete genometranscriptional regulator, AsnC family6e-1166.6
NC_013156:980888:998757998757999179423Methanocaldococcus fervens AG86, complete genometranscriptional regulator, AsnC family3e-0650.8
NC_010723:2873886:288693528869352887414480Clostridium botulinum E3 str. Alaska E43, complete genometranscriptional regulator, AsnC family4e-63239
NC_013202:2042776:206226820622682062762495Halomicrobium mukohataei DSM 12286, complete genometranscriptional regulator, AsnC family2e-21101
NC_013887:1402980:141868614186861419108423Methanocaldococcus sp. FS406-22 chromosome, complete genometranscriptional regulator, AsnC family1e-0652.4
NC_010674:3049500:306338830633883063867480Clostridium botulinum B str. Eklund 17B, complete genometranscriptional regulator, AsnC family4e-63239