Pre_GI: BLASTP Hits

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Query: NC_008593:609723:614967 Clostridium novyi NT, complete genome

Start: 614967, End: 616343, Length: 1377

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014150:1902241:1902241190224119045172277Brachyspira murdochii DSM 12563 chromosome, complete genomeTetratricopeptide TPR_2 repeat protein4e-1066.6
NC_010511:637214:6417186417186448883171Methylobacterium sp. 4-46 chromosome, complete genomepeptidase C14 caspase catalytic subunit p205e-1066.2
NC_011894:2549076:2561841256184125649093069Methylobacterium nodulans ORS 2060, complete genomepeptidase C14 caspase catalytic subunit p206e-1065.9
NC_011894:7421867:7434437743443774374032967Methylobacterium nodulans ORS 2060, complete genomepeptidase C14 caspase catalytic subunit p205e-0962.8
NC_008312:2690000:2690649269064926918961248Trichodesmium erythraeum IMS101, complete genomeheat shock protein DnaJ-like2e-0860.8
NC_013223:1349000:136274613627461363693948Desulfohalobium retbaense DSM 5692, complete genomeTPR repeat-containing protein3e-0860.5
NC_019977:1245894:1262204126220412649452742Methanomethylovorans hollandica DSM 15978, complete genomeputative endonuclease related to Holliday junction resolvase4e-0859.7
NC_011894:6295807:6299486629948663026563171Methylobacterium nodulans ORS 2060, complete genomepeptidase C14 caspase catalytic subunit p205e-0859.7
NC_011894:3029964:3038773303877330411272355Methylobacterium nodulans ORS 2060, complete genomepeptidase C14 caspase catalytic subunit p207e-0858.9
NC_015519:2739347:274317527431752743702528Tepidanaerobacter sp. Re1 chromosome, complete genomehypothetical protein1e-0758.2
NC_009012:1595498:1602930160293016040901161Clostridium thermocellum ATCC 27405, complete genomechaperone protein DnaJ2e-0757.8
NC_011894:2503639:2517451251745125199072457Methylobacterium nodulans ORS 2060, complete genomepeptidase C14 caspase catalytic subunit p202e-0757.4
NC_014836:2620871:2642534264253426436641131Desulfurispirillum indicum S5 chromosome, complete genomechaperone protein DnaJ5e-0756.2
NC_000916:31459:415174151742203687Methanothermobacter thermautotrophicus str. Delta H, completeTPR-repeat-containing protein6e-0755.8
NC_014408:1018448:1026328102632810275481221Methanothermobacter marburgensis str. Marburg chromosome, completetetratricopeptide repeat domain-containing protein7e-0755.8
NC_003454:249304:2679022679022697881887Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeTetratricopeptide repeat family protein9e-0755.5
NC_004842:1132441:1143119114311911442581140Anaplasma marginale str. St. Maries, complete genomeDNAJ protein8e-0755.5
NC_012026:1135041:1147323114732311484621140Anaplasma marginale str. Florida, complete genomeDNAJ protein (dnaJ)8e-0755.5
NC_000916:31459:5142651426525651140Methanothermobacter thermautotrophicus str. Delta H, completeO-linked GlcNAc transferase8e-0755.5
NC_013532:85371:99424994241005661143Anaplasma centrale str. Israel, complete genomechaperone protein DnaJ7e-0755.5
NC_008312:4731692:4731692473169247340342343Trichodesmium erythraeum IMS101, complete genomeTPR repeat1e-0655.1
NC_016627:3205333:3213891321389132150421152Clostridium clariflavum DSM 19732 chromosome, complete genomechaperone protein DnaJ1e-0655.1
NC_018515:4148037:4157715415771541588271113Desulfosporosinus meridiei DSM 13257 chromosome, complete genomechaperone protein DnaJ2e-0654.3
NC_002570:1426000:1434608143460814357201113Bacillus halodurans C-125, complete genomeheat-shock protein (activation of DnaK)2e-0653.9
NC_015416:223968:241305241305242090786Methanosaeta concilii GP-6 chromosome, complete genomeTPR-repeat-containing protein2e-0653.9
NC_003909:1139556:1153354115335411591465793Bacillus cereus ATCC 10987, complete genomestage V sporulation protein K3e-0653.5
NC_014935:711765:730717730717731604888Nitratifractor saLSUginis DSM 16511 chromosome, complete genomeheat shock protein dnaj domain protein3e-0653.5
NC_007517:1676604:1706070170607017082592190Geobacter metallireducens GS-15, complete genomeTetratricopeptide TPR_44e-0653.1
NC_000963:205546:2214412214412225531113Rickettsia prowazekii str. Madrid E, complete genomeDNAJ PROTEIN (dnaJ)5e-0652.8
NC_017048:547712:5636065636065647181113Rickettsia prowazekii str. GvV257 chromosome, complete genomechaperone protein DnaJ5e-0652.8
NC_017049:203748:2196412196412207531113Rickettsia prowazekii str. Chernikova chromosome, complete genomechaperone protein DnaJ5e-0652.8
NC_017050:205547:2214422214422225541113Rickettsia prowazekii str. Katsinyian chromosome, complete genomechaperone protein DnaJ5e-0652.8
NC_017051:203752:2196452196452207571113Rickettsia prowazekii str. Dachau chromosome, complete genomechaperone protein DnaJ5e-0652.8
NC_017056:205558:2214502214502225621113Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genomechaperone protein DnaJ5e-0652.8
NC_017057:205771:2216652216652227771113Rickettsia prowazekii str. RpGvF24 chromosome, complete genomechaperone protein DnaJ5e-0652.8
NC_016751:1227495:1240812124081212419451134Marinitoga piezophila KA3 chromosome, complete genomechaperone protein DnaJ6e-0652.4
NC_014150:2617072:2626326262632626285782253Brachyspira murdochii DSM 12563 chromosome, complete genomeTPR repeat-containing protein7e-0652.4
NC_020126:2883194:288319428831942883916723Myxococcus stipitatus DSM 14675, complete genomehypothetical protein7e-0652.4
NC_010814:2217153:2236817223681722385171701Geobacter lovleyi SZ, complete genomeTetratricopeptide TPR_2 repeat protein9e-0652