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Query: NC_008593:609723:611561 Clostridium novyi NT, complete genome

Start: 611561, End: 611848, Length: 288

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:641000:660238660238660543306Clostridium botulinum BKT015925 chromosome, complete genomePTS system transporter subunit IIB5e-38155
NC_004431:279868:307212307212307499288Escherichia coli CFT073, complete genomehypothetical protein3e-1373.6
NC_008800:1459015:148022214802221480509288Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,phosphotransferase enzyme II, B component3e-1270.1
NC_015224:3225000:322552132255213225808288Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,phosphotransferase enzyme II, B component3e-1270.1
NC_012467:1997484:199884319988431999127285Streptococcus pneumoniae P1031, complete genomephosphotransferase system, galactitol-specific IIB component6e-1269.3
NC_012926:140000:176952176952177236285Streptococcus suis BM407 chromosome, complete genomePTS system lactose/cellobiose-specific family transporter subunit IIB3e-1167.4
NC_007712:3511500:351721135172113517483273Sodalis glossinidius str. 'morsitans', complete genomeputative PTS system IIB component3e-1167
NC_013198:394000:405249405249405530282Lactobacillus rhamnosus GG, complete genomePTS system, lactose/cellobiose/mannitol/pentitol/galactitol/fructose/L -ascorbate-specific EIIB component (lipoprotein, SgaB, SgaT)1e-1065.1
NC_014228:2812000:283069528306952830982288Xenorhabdus nematophila ATCC 19061, complete genomeputative sugar phosphotransferase component II B5e-0960.1
NC_014915:2092678:212691921269192127203285Geobacillus sp. Y412MC52 chromosome, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit5e-0960.1
NC_013411:2975364:298698829869882987272285Geobacillus sp. Y412MC61, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit5e-0960.1
NC_013508:3188978:319260131926013192888288Edwardsiella tarda EIB202, complete genomephosphotransferase enzyme II, B component1e-0858.5
NC_003210:2721559:272288427228842723156273Listeria monocytogenes EGD-e, complete genomehypothetical protein5e-0856.6
NC_014831:2201246:221381922138192214118300Thermaerobacter marianensis DSM 12885 chromosome, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit4e-0753.5
NC_009648:1914621:192832219283221928588267Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomePTS family protein II component2e-0650.8
NC_012731:2650603:266430226643022664568267Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomeascorbate-specific PTS family enzyme IIB component2e-0650.8
NC_016845:2691129:270484927048492705115267Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,PTS family protein II component2e-0650.8
NC_020181:969599:975575975575975841267Enterobacter aerogenes EA1509E, complete genomeFIG01225319: hypothetical protein2e-0650.8
NC_015663:4447984:446125044612504461516267Enterobacter aerogenes KCTC 2190 chromosome, complete genomeascorbate-specific PTS family enzyme IIB component2e-0650.8
NC_009053:1942973:194776319477631948035273Actinobacillus pleuropneumoniae L20, complete genomePhosphotransferase system, galactitol-specific IIB component2e-0650.8