Pre_GI: BLASTP Hits

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Query: NC_008593:555463:571795 Clostridium novyi NT, complete genome

Start: 571795, End: 574032, Length: 2238

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:604842:6223606223606246002241Clostridium botulinum BKT015925 chromosome, complete genomeribonuclease R01320
NC_009697:256354:2671232671232693002178Clostridium botulinum A str. ATCC 19397 chromosome, completeribonuclease R01076
NC_014328:4249032:4253288425328842554262139Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ribonuclease R01040
NC_004557:363628:3762663762663783922127Clostridium tetani E88, complete genomeexoribonuclease II01031
NC_010674:3141228:3151182315118231534222241Clostridium botulinum B str. Eklund 17B, complete genomeribonuclease R0965
NC_011567:2468708:2468708246870824709842277Anoxybacillus flavithermus WK1, complete genomeExoribonuclease R0805
NC_017200:4915780:4915780491578049182062427Bacillus thuringiensis serovar finitimus YBT-020 chromosome,ribonuclease R0795
NC_012472:4867210:4867210486721048696482439Bacillus cereus 03BB102, complete genomeribonuclease R0795
NC_011773:4914601:4914601491460149170212421Bacillus cereus AH820 chromosome, complete genomeribonuclease R0794
NC_005957:4850659:4857959485795948603732415Bacillus thuringiensis serovar konkukian str. 97-27, completeribonuclease R (RNase R)0793
NC_006274:4910465:4910465491046549128972433Bacillus cereus E33L, complete genomeribonuclease R (RNase R)0793
NC_011725:5043198:5043198504319850456242427Bacillus cereus B4264 chromosome, complete genomeribonuclease R0793
NC_004722:5027762:5031501503150150339272427Bacillus cereus ATCC 14579, complete genomeExoribonuclease II0793
NC_017208:5096759:5096759509675950992032445Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeexoribonuclease II0791
NC_011658:4866184:4866184486618448686042421Bacillus cereus AH187 chromosome, complete genomeribonuclease R0791
NC_014335:4800500:4803111480311148055312421Bacillus cereus biovar anthracis str. CI chromosome, completeribonuclease R0791
NC_010184:4879552:4884254488425448866982445Bacillus weihenstephanensis KBAB4, complete genomeribonuclease R0790
NC_011772:4994500:4996953499695349993912439Bacillus cereus G9842, complete genomeribonuclease R0789
NC_014614:757381:7773497773497794692121Clostridium sticklandii, complete genomeribonuclease R0787
NC_014479:3245126:3245126324512632474652340Bacillus subtilis subsp. spizizenii str. W23 chromosome, completeribonuclease R0785
NC_013406:303218:3080613080613106912631Paenibacillus sp. Y412MC10 chromosome, complete genomeribonuclease R0784
NC_016593:3116145:3132693313269331349692277Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completeribonuclease R0781
NC_009674:3732000:3732119373211937344972379Bacillus cytotoxicus NVH 391-98 chromosome, complete genomeribonuclease R0781
NC_009437:1481064:1485624148562414878042181Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeribonuclease R0778
NC_014829:3741843:3757484375748437598622379Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeribonuclease R0760
NC_015949:1957185:1973672197367219758222151Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomeribonuclease R0756
NC_014721:508000:5127465127465148962151Caldicellulosiruptor kristjanssonii 177R1B chromosome, completeribonuclease r0754
NC_015519:1081539:1081539108153910836532115Tepidanaerobacter sp. Re1 chromosome, complete genomeribonuclease R0720
NC_007644:280000:2810772810772833892313Moorella thermoacetica ATCC 39073, complete genomeRibonuclease R0716
NC_010718:2116889:2118239211823921203682130Natranaerobius thermophilus JW/NM-WN-LF, complete genomeribonuclease R0713
NC_015977:2445835:2459938245993824621152178Roseburia hominis A2-183 chromosome, complete genomeribonuclease R0674
NC_018665:2163713:2178509217850921808662358Exiguobacterium antarcticum B7 chromosome, complete genomeRibonuclease R0646
NC_010556:2328303:2340608234060823429652358Exiguobacterium sibiricum 255-15, complete genomeribonuclease R0643
NC_013740:1081454:1101239110123911037102472Acidaminococcus fermentans DSM 20731, complete genomeribonuclease R0643
NC_011999:558057:5605385605385628592322Macrococcus caseolyticus JCSC5402, complete genomeVacB/RNase II family exoribonuclease0639
NC_007350:1971762:1973249197324919756392391Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305,exoribonuclease0637
NC_016941:807155:8243308243308267022373Staphylococcus aureus subsp. aureus MSHR1132, complete genomeputative ribonuclease R0636
NC_012673:785718:8037798037798061842406Exiguobacterium sp. AT1b, complete genomeribonuclease R0635
NC_009487:866000:8826728826728850442373Staphylococcus aureus subsp. aureus JH9 chromosome, completeribonuclease R0635
NC_002745:840848:8408488408488432202373Staphylococcus aureus subsp. aureus N315, complete genomeribonuclease R0635
NC_017353:2129738:2131550213155021339252376Staphylococcus lugdunensis N920143, complete genomeputative ribonuclease R1e-180633
NC_017342:2486000:2505106250510625074782373Staphylococcus aureus subsp. aureus TCH60 chromosome, completeribonuclease R2e-180632
NC_017337:853221:8532218532218555932373Staphylococcus aureus subsp. aureus ED133 chromosome, completeribonuclease R5e-180631
NC_014624:2668157:2695671269567126978242154Eubacterium limosum KIST612 chromosome, complete genomeribonuclease R8e-165581
NC_011978:1812000:1818095181809518202272133Thermotoga neapolitana DSM 4359, complete genomeRibonuclease R5e-154545
NC_013642:505518:5186435186435207752133Thermotoga naphthophila RKU-10, complete genomeribonuclease R6e-152538
NC_015214:437733:4644614644614668032343Lactobacillus acidophilus 30SC chromosome, complete genomeexoribonuclease R7e-152538
NC_014724:439594:4647134647134670552343Lactobacillus amylovorus GRL 1112 chromosome, complete genomeRibonuclease R2e-151536
NC_011296:1039749:1041105104110510431922088Thermodesulfovibrio yellowstonii DSM 11347, complete genomeribonuclease R3e-150533
NC_018528:446610:4704974704974728362340Lactobacillus helveticus R0052 chromosome, complete genomeexoribonuclease R6e-149528
NC_015602:117939:1389961389961413382343Lactobacillus kefiranofaciens ZW3 chromosome, complete genomeexoribonuclease R1e-148527
NC_010080:445398:4647954647954671342340Lactobacillus helveticus DPC 4571, complete genomeExoribonuclease R9e-148524
NC_014106:419511:4420204420204443592340Lactobacillus crispatus ST1, complete genomeRibonuclease R3e-147522
NC_012968:1108687:1132872113287211353792508Methylotenera mobilis JLW8, complete genomeribonuclease R9e-143508
NC_012997:541648:5601225601225627042583Teredinibacter turnerae T7901, complete genomeribonuclease R6e-143508
NC_010278:1625695:1653374165337416557312358Actinobacillus pleuropneumoniae serovar 3 str. JL03 chromosome,ribonuclease R7e-141501
NC_009053:1668500:1692326169232616946832358Actinobacillus pleuropneumoniae L20, complete genomeribonuclease R8e-141501
NC_009615:4031335:4052763405276340549492187Parabacteroides distasonis ATCC 8503 chromosome, complete genomeribonuclease R8e-140498
NC_010939:1633000:1656085165608516584422358Actinobacillus pleuropneumoniae serovar 7 str. AP76, completeribonuclease R2e-138493
NC_015164:2859000:2867915286791528700622148Bacteroides salanitronis DSM 18170 chromosome, complete genomeribonuclease R2e-137490
NC_008150:4373722:4394584439458443971182535Yersinia pestis Antiqua, complete genomeribonuclease R1e-136487
NC_017168:687471:7083337083337108672535Yersinia pestis A1122 chromosome, complete genomeexoribonuclease R1e-136487
NC_012214:594667:5946675946675971082442Erwinia pyrifoliae Ep1/96, complete genomeRibonuclease R5e-132472
NC_015930:821342:8357518357518377512001Lactococcus garvieae ATCC 49156, complete genomeexoribonuclease8e-130464
NC_015161:792955:8127928127928170964305Deinococcus proteolyticus MRP chromosome, complete genomeribonuclease R2e-124446
NC_020304:2107979:2149365214936521515752211Desulfocapsa sulfexigens DSM 10523, complete genomeRNAse R6e-122438
NC_008781:2575213:2575213257521325773722160Polaromonas naphthalenivorans CJ2, complete genomeribonuclease R8e-119428
NC_013895:35410:5505155051570031953Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completeputative ribonuclease R2e-116420
NC_019960:1658657:1723732172373217259302199Prevotella dentalis DSM 3688 chromosome 1, complete sequenceribonuclease R3e-113409
NC_016779:4825599:4825599482559948269241326Bacillus cereus F837/76 chromosome, complete genome3'-to-5' exoribonuclease RNase R2e-111404
NC_012225:787737:7885747885747905591986Brachyspira hyodysenteriae WA1, complete genomeVacB, Exoribonuclease R2e-100367
NC_017243:1229597:1245309124530912473001992Brachyspira intermedia PWS/A chromosome, complete genomeVacB, Exoribonuclease R5e-100365
NC_007481:3167434:3167434316743431696832250Pseudoalteromonas haloplanktis TAC125 chromosome I, completecold-shock RNAse R1e-99364
NC_004603:1961432:1971918197191819741432226Vibrio parahaemolyticus RIMD 2210633 chromosome I, completeputative virulence-associated protein VacB/RNase R4e-99362
NC_016779:4825599:4827012482701248280221011Bacillus cereus F837/76 chromosome, complete genome3'-to-5' exoribonuclease RNase R2e-94347
NC_004552:235769:2535432535432555912049Chlamydophila abortus S26/3, complete genomeputative ribonuclease3e-91337
NC_002179:237854:2530682530682550982031Chlamydophila pneumoniae AR39, complete genomeexoribonuclease, VacB/Rnb family1e-89331
NC_002491:585807:5858075858075878372031Chlamydophila pneumoniae J138, complete genomeribonuclease family1e-89331
NC_002620:803696:8077458077458098232079Chlamydia muridarum Nigg, complete genomeexoribonuclease, VacB/Rnb family2e-89330
NC_015744:769907:7721827721827742662085Chlamydia trachomatis L2c chromosome, complete genomeribonuclease R2e-88327
NC_010287:769600:7724737724737745572085Chlamydia trachomatis 434/Bu, complete genomeexoribonuclease II2e-88327
NC_010280:769639:7725127725127745962085Chlamydia trachomatis L2b/UCH-1/proctitis, complete genomeexoribonuclease II2e-88327
NC_017439:451535:4544084544084564922085Chlamydia trachomatis E/150 chromosome, complete genomeexoribonuclease II1e-87325
NC_017431:451551:4544244544244565082085Chlamydia trachomatis E/11023 chromosome, complete genomeexoribonuclease II1e-87325
NC_007604:1967770:1986376198637619886132238Synechococcus elongatus PCC 7942, complete genomeCold shock protein3e-70266
NC_006576:2328427:2328427232842723306732247Synechococcus elongatus PCC 6301, complete genomeprotein conferring resistance to acetazolamide Zam2e-69264
NC_017506:3717261:3741721374172137437061986Marinobacter adhaerens HP15 chromosome, complete genomeexoribonuclease R2e-55217
NC_020063:2480983:2500855250085525027891935Enterobacteriaceae bacterium strain FGI 57, complete genomeexoribonuclease II5e-41170
NC_002932:937157:9484789484789499411464Chlorobium tepidum TLS, complete genomeribonuclease II family protein5e-39163
NC_011147:1239904:1239904123990412418381935Salmonella enterica subsp. enterica serovar Paratyphi A strexoribonuclease II1e-37158
NC_006511:1243817:1246061124606112479951935Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCCexoribonuclease II1e-37158
NC_016614:1178000:1211087121108712130872001Vibrio sp. EJY3 chromosome 2, complete sequenceexoribonuclease II3e-33144
NC_013457:1703201:1720072172007217220752004Vibrio sp. Ex25 chromosome 2, complete genomeexoribonuclease II6e-33143
NC_020389:571466:5714665714665732651800Methanosarcina mazei Tuc01, complete genomeExoribonuclease II2e-32141
NC_008319:1167213:1188453118845311908342382Synechococcus sp. CC9311, complete genomeacetazolamide conferring resistance protein Zam4e-32140
NC_015966:2875140:2888019288801928899981980Rhodothermus marinus SG0.5JP17-172 chromosome, complete genomeExoribonuclease II1e-31138
NC_005071:835005:8350058350058373982394Prochlorococcus marinus str. MIT 9313, complete genomeputative acetazolamide conferring resistance protein Zam3e-31137
NC_011884:2551715:2551715255171525535621848Cyanothece sp. PCC 7425, complete genomeribonuclease II8e-31135
NC_006576:456569:4775044775044795162013Synechococcus elongatus PCC 6301, complete genomeribonuclease II3e-30134
NC_005071:786000:8074968074968095622067Prochlorococcus marinus str. MIT 9313, complete genomeprobable ribonuclease II3e-25117
NC_008819:936929:9399969399969412701275Prochlorococcus marinus str. NATL1A, complete genomeprobable ribonuclease II3e-23110
NC_007335:331072:3358963358963371701275Prochlorococcus marinus str. NATL2A, complete genomeexoribonuclease R/ribonuclease II1e-22108
NC_007513:1126914:1126914112691411292682355Synechococcus sp. CC9902, complete genomeRNA binding S19e-1789.4
NC_012522:98567:1200181200181218921875Rhodococcus opacus B4, complete genomeputative ribonuclease3e-1687.4
NC_008269:577111:5906135906135924601848Rhodococcus sp. RHA1 plasmid pRHL1, complete sequenceprobable exoribonuclease II7e-1686.7
NC_008767:273759:2882982882982901781881Neisseria meningitidis FAM18, complete genomehypothetical protein5e-1273.6
NC_011999:2023248:204089120408912041277387Macrococcus caseolyticus JCSC5402, complete genomehypothetical protein1e-0655.5