Pre_GI: BLASTP Hits

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Query: NC_008593:555463:561495 Clostridium novyi NT, complete genome

Start: 561495, End: 562571, Length: 1077

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:604842:6120066120066130821077Clostridium botulinum BKT015925 chromosome, complete genomesugar ABC transporter permease5e-151533
NC_016627:1960097:1968797196879719699151119Clostridium clariflavum DSM 19732 chromosome, complete genomeABC transporter permease5e-52205
NC_009012:1901492:1910020191002019111381119Clostridium thermocellum ATCC 27405, complete genomeinner-membrane translocator3e-51202
NC_019970:2263427:2280233228023322812881056Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeABC-type uncharacterized transport system, permease component1e-43177
NC_013517:1249466:1253897125389712549611065Sebaldella termitidis ATCC 33386, complete genomeinner-membrane translocator2e-42173
NC_013517:1916020:1923299192329919243631065Sebaldella termitidis ATCC 33386, complete genomeinner-membrane translocator2e-42173
NC_015555:1989463:2008288200828820093431056Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeABC-type transporter, integral membrane subunit5e-42172
NC_014614:1259236:1272508127250812735721065Clostridium sticklandii, complete genomeABC transporter, permease4e-41169
NC_011661:1175743:1174647117464711757501104Dictyoglomus turgidum DSM 6724, complete genomeinner-membrane translocator3e-40166
NC_009617:4761000:4767914476791447690411128Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeinner-membrane translocator1e-39164
NC_009617:3647500:3652264365226436533911128Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeinner-membrane translocator3e-39162
NC_013517:825100:8265988265988276861089Sebaldella termitidis ATCC 33386, complete genomeinner-membrane translocator6e-38158
NC_010723:3499291:3509005350900535100661062Clostridium botulinum E3 str. Alaska E43, complete genomesugar ABC transporter, permease protein5e-38158
NC_008262:1721496:1737591173759117386881098Clostridium perfringens SM101, complete genomeABC transporter (permease proteins)-like protein lmo13901e-37157
NC_014614:432000:4392694392694403301062Clostridium sticklandii, complete genomeYufP5e-37155
NC_013171:312500:3317783317783329441167Anaerococcus prevotii DSM 20548, complete genomeinner-membrane translocator2e-36153
NC_015500:78223:7973679736807791044Treponema brennaborense DSM 12168 chromosome, complete genomeABC-type transporter, integral membrane subunit3e-36152
NC_013169:805124:8038448038448051271284Kytococcus sedentarius DSM 20547, complete genomenucleoside ABC transporter membrane protein1e-35150
NC_008212:1685367:1694022169402216951131092Haloquadratum walsbyi DSM 16790, complete genomeABC-type ribose transport system, permease protein1e-34147
NC_015152:2622000:2635976263597626370881113Spirochaeta sp. Buddy chromosome, complete genomeABC transporter inner membrane protein2e-33143
NC_014364:111000:1256021256021267171116Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeinner-membrane translocator1e-32140
NC_010723:2873886:2879822287982228809761155Clostridium botulinum E3 str. Alaska E43, complete genomeABC transporter, permease protein5e-32138
NC_010674:3049500:3056417305641730575711155Clostridium botulinum B str. Eklund 17B, complete genomeABC transporter, permease protein1e-31137
NC_012472:3625800:3645222364522236462801059Bacillus cereus 03BB102, complete genomesugar ABC transporter, permease protein1e-31137
NC_008600:3611038:3627215362721536282731059Bacillus thuringiensis str. Al Hakam, complete genomeABC transporter, permease1e-31137
NC_013517:3846747:3852715385271538537461032Sebaldella termitidis ATCC 33386, complete genomeinner-membrane translocator3e-31135
NC_017200:3622838:3642152364215236432101059Bacillus thuringiensis serovar finitimus YBT-020 chromosome,sugar ABC transporter permease4e-31135
NC_008570:236500:2374942374942386091116Aeromonas hydrophila subsp. hydrophila ATCC 7966, complete genomeputative transport system permease abc transporter protein8e-31134
NC_014364:815346:8762108762108772531044Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeinner-membrane translocator2e-30133
NC_020291:5093138:5103323510332351045431221Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomenucleoside ABC transporter membrane protein2e-30133
NC_007802:1240989:1260529126052912615721044Jannaschia sp. CCS1, complete genomeinner-membrane translocator7e-30131
NC_020291:1810527:1821906182190618231261221Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomesugar ABC transporter, permease protein7e-30131
NC_016633:14000:1823718237192591023Sphaerochaeta pleomorpha str. Grapes chromosome, complete genomeABC transporter permease8e-29128
NC_017079:261736:2973132973132984311119Caldilinea aerophila DSM 14535 = NBRC 104270, complete genomeABC transporter permease1e-28127
NC_013205:19295:4301743017440901074Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,inner-membrane translocator3e-28125
NC_012785:1960500:1963226196322619642631038Kosmotoga olearia TBF 19.5.1, complete genomeinner-membrane translocator4e-28125
NC_013192:664408:6700456700456711121068Leptotrichia buccalis DSM 1135, complete genomeinner-membrane translocator2e-27124
NC_016751:1524848:1536238153623815373921155Marinitoga piezophila KA3 chromosome, complete genomeABC transporter permease3e-27122
NC_014363:1396912:1420413142041314215311119Olsenella uli DSM 7084 chromosome, complete genomenucleoside ABC transporter membrane protein7e-25115
NC_010725:4618000:4631792463179246329341143Methylobacterium populi BJ001, complete genomeinner-membrane translocator2e-24113
NC_008710:703740:7200767200767212271152Borrelia turicatae 91E135, complete genomenucleoside transport system permease protein8e-24111
NC_001263:243000:2454862454862474982013Deinococcus radiodurans R1 chromosome 1, complete sequencehypothetical protein1e-23110
NC_008054:1815723:1834159183415918352981140Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completeABC transporter, permease protein3e-23109
NC_010673:703816:7226587226587238091152Borrelia hermsii DAH, complete genomenucleoside transport system permease protein6e-23108
NC_015315:1458803:1460898146089814619051008Thermoproteus uzoniensis 768-20 chromosome, complete genomeinner-membrane translocator1e-22107
NC_014150:2399997:2405465240546524065261062Brachyspira murdochii DSM 12563 chromosome, complete genomeinner-membrane translocator2e-22106
NC_014330:1957725:1976699197669919778201122Brachyspira pilosicoli 95/1000 chromosome, complete genomeinner-membrane translocator3e-22106
NC_013967:1878045:1878045187804518791751131Haloferax volcanii DS2 chromosome, complete genomeABC-type transport system permease protein (probable substrate sugar)7e-22105
NC_017075:4880807:4880807488080748819071101Rubrivivax gelatinosus IL144, complete genomeputative ABC transporter permease7e-22105
NC_014150:1123570:1128252112825211293671116Brachyspira murdochii DSM 12563 chromosome, complete genomeinner-membrane translocator1e-21104
NC_014168:994640:9972819972819983541074Segniliparus rotundus DSM 44985 chromosome, complete genomeinner-membrane translocator1e-21104
NC_017075:4880807:4902094490209449031521059Rubrivivax gelatinosus IL144, complete genomeputative ABC transporter permease4e-21102
NC_017243:314000:3156913156913168061116Brachyspira intermedia PWS/A chromosome, complete genomeinner-membrane-translocator5e-21102
NC_012225:1775264:1792295179229517934101116Brachyspira hyodysenteriae WA1, complete genomeinner-membrane-translocator9e-21101
NC_015474:252390:2707762707762717771002Pyrococcus sp. NA2 chromosome, complete genomeribose ABC transporter, permease protein3e-1996.7
NC_009376:1442314:1442314144231414433181005Pyrobaculum arsenaticum DSM 13514 chromosome, complete genomeinner-membrane translocator4e-1995.9
NC_014328:3294086:3306387330638733074751089Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ABC transporter permease4e-1995.9
NC_021182:380500:3989253989253999981074Clostridium pasteurianum BC1, complete genomeABC-type uncharacterized transport system, permease component3e-1893.2
NC_000961:1481685:1503359150335915043721014Pyrococcus horikoshii OT3, complete genomehypothetical protein2e-1790.5
NC_011985:1831961:1853200185320018542941095Agrobacterium radiobacter K84 chromosome 1, complete genomesugar ABC transporter1e-1687.8
NC_000868:416958:437044437044438033990Pyrococcus abyssi GE5, complete genomeribose ABC transporter, permease protein1e-1687.4
NC_010001:986500:9901339901339912331101Clostridium phytofermentans ISDg, complete genomeinner-membrane translocator5e-1685.5
NC_015138:2270181:2270181227018122712421062Acidovorax avenae subsp. avenae ATCC 19860 chromosome, completeinner-membrane translocator9e-1684.7
NC_015856:268034:2696852696852707911107Collimonas fungivorans Ter331 chromosome, complete genomeputative transmembrane ABC transporter protein8e-1478.2
NC_011772:3705878:372787737278773728836960Bacillus cereus G9842, complete genomesugar ABC transporter, permease protein2e-1273.6
NC_013517:3846747:385178138517813852710930Sebaldella termitidis ATCC 33386, complete genomeinner-membrane translocator5e-1272.4
NC_016627:1960097:196786219678621968797936Clostridium clariflavum DSM 19732 chromosome, complete genomeABC transporter permease6e-1272
NC_008600:3611038:362625536262553627214960Bacillus thuringiensis str. Al Hakam, complete genomeABC transporter, permease7e-1272
NC_012472:3625800:364426236442623645221960Bacillus cereus 03BB102, complete genomesugar ABC transporter, permease protein7e-1272
NC_017200:3622838:364119236411923642151960Bacillus thuringiensis serovar finitimus YBT-020 chromosome,sugar ABC transporter permease1e-1171.2
NC_009012:1901492:191113919111391912074936Clostridium thermocellum ATCC 27405, complete genomeinner-membrane translocator2e-1170.1
NC_009617:3647500:365139036513903652274885Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeinner-membrane translocator6e-1168.9
NC_014614:1259236:127357712735771274509933Clostridium sticklandii, complete genomeNucleoside transport system permease protein7e-1168.6
NC_008054:1815723:183529818352981836254957Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completeABC transporter, permease protein9e-1168.2
NC_009617:4761000:476704047670404767924885Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeinner-membrane translocator2e-1067
NC_015425:604842:613075613075613992918Clostridium botulinum BKT015925 chromosome, complete genomesugar ABC transporter permease2e-0963.9
NC_008593:555463:562564562564563481918Clostridium novyi NT, complete genomeABC transporter, permease protein2e-0963.5
NC_006055:769418:7733867733867752241839Mesoplasma florum L1, complete genomeribose ABC transporter permease component4e-0962.8
NC_008212:1685367:1695106169510616962271122Haloquadratum walsbyi DSM 16790, complete genomeABC-type ribose transport system, permease protein1e-0860.8
NC_019970:2263427:227931322793132280236924Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeputative ABC-type transport system, permease component6e-0858.9
NC_013205:19295:420634206342980918Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,inner-membrane translocator8e-0858.5
NC_014150:2399997:240654924065492407487939Brachyspira murdochii DSM 12563 chromosome, complete genomeinner-membrane translocator1e-0758.2
NC_015555:1989463:200736820073682008291924Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeABC-type transporter, integral membrane subunit1e-0758.2
NC_013517:825100:827670827670828575906Sebaldella termitidis ATCC 33386, complete genomeinner-membrane translocator1e-0758.2
NC_016751:1524848:153738915373891538312924Marinitoga piezophila KA3 chromosome, complete genomeABC transporter permease3e-0756.6
NC_013192:664408:671159671159672028870Leptotrichia buccalis DSM 1135, complete genomeinner-membrane translocator4e-0756.2
NC_015474:252390:269871269871270779909Pyrococcus sp. NA2 chromosome, complete genomeribose ABC transporter, permease protein4e-0755.8
NC_017075:4880807:488190048819004882868969Rubrivivax gelatinosus IL144, complete genomeputative ABC transporter permease5e-0755.8
NC_014364:111000:126707126707127633927Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeinner-membrane translocator9e-0755.1
NC_009033:133800:1353691353691364451077Staphylothermus marinus F1, complete genomeinner-membrane translocator8e-0755.1
NC_000868:416958:438030438030438938909Pyrococcus abyssi GE5, complete genomeribose ABC transporter, permease protein1e-0654.3
NC_013967:1878045:1879172187917218802271056Haloferax volcanii DS2 chromosome, complete genomeABC-type transport system permease protein (probable substrate sugar)1e-0654.3
NC_012796:345000:3638323638323648751044Desulfovibrio magneticus RS-1, complete genomeABC transporter permease protein5e-0652.4
NC_014614:432000:440820440820441233414Clostridium sticklandii, complete genomesugar ABC transporter, permease protein (fragment)7e-0652