Pre_GI: BLASTP Hits

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Query: NC_008593:2527064:868 Clostridium novyi NT, complete genome

Start: 868, End: 1080, Length: 213

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011898:4044500:406745040674504067665216Clostridium cellulolyticum H10, complete genomeprotein of unknown function DUF376e-22102
NC_006576:2610565:263388926338892634137249Synechococcus elongatus PCC 6301, complete genomehypothetical protein1e-2098.6
NC_007604:1512709:153666415366641536912249Synechococcus elongatus PCC 7942, complete genomeProtein of unknown function DUF371e-2098.6
NC_016627:4871875:489666948966694896884216Clostridium clariflavum DSM 19732 chromosome, complete genomehypothetical protein1e-2098.2
NC_015519:2739347:275896527589652759174210Tepidanaerobacter sp. Re1 chromosome, complete genomehypothetical protein2e-2097.8
NC_015387:1002955:102194010219401022176237Marinithermus hydrothermalis DSM 14884 chromosome, complete genomeUPF0161 protein yidD1e-1994.7
NC_006177:3549467:356489735648973565109213Symbiobacterium thermophilum IAM 14863, complete genomeputative alpha-hemolysin3e-1994
NC_009483:5113729:513541651354165135628213Geobacter uraniireducens Rf4 chromosome, complete genomehypothetical protein5e-1992.8
NC_014915:2963500:300927830092783009520243Geobacillus sp. Y412MC52 chromosome, complete genomeprotein of unknown function DUF371e-1891.7
NC_014392:2513529:252696225269622527189228Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomehypothetical protein5e-1889.7
NC_020260:3931567:393637439363743936631258Cronobacter sakazakii Sp291, complete genomehypothetical protein7e-1889.4
NC_008463:3394000:339540133954013395661261Pseudomonas aeruginosa UCBPP-PA14, complete genomehypothetical protein1e-1788.6
NC_011770:3626000:362702336270233627283261Pseudomonas aeruginosa LESB58, complete genomehypothetical protein1e-1788.2
NC_002516:2222896:223854122385412238801261Pseudomonas aeruginosa PAO1, complete genomehypothetical protein1e-1788.2
NC_008576:4701930:471847347184734718682210Magnetococcus sp. MC-1, complete genomeprotein of unknown function DUF372e-1787.8
NC_013595:10329633:103402541034025410340532279Streptosporangium roseum DSM 43021, complete genomehypothetical protein2e-1787.8
NC_014363:2035141:204929520492952049537243Olsenella uli DSM 7084 chromosome, complete genomeprotein of unknown function DUF373e-1787.4
NC_014151:4106624:412188741218874122183297Cellulomonas flavigena DSM 20109 chromosome, complete genomeprotein of unknown function DUF373e-1787
NC_013192:2434664:246475724647572464966210Leptotrichia buccalis DSM 1135, complete genomeprotein of unknown function DUF373e-1787
NC_007516:731193:753169753169753447279Synechococcus sp. CC9605, complete genomeProtein of unknown function DUF374e-1786.7
NC_000911:2747604:275057727505772750816240Synechocystis sp. PCC 6803, complete genomehypothetical protein6e-1786.3
NC_017039:2745432:274840527484052748644240Synechocystis sp. PCC 6803 substr. PCC-P, complete genomehypothetical protein6e-1786.3
NC_017052:2745420:274839327483932748632240Synechocystis sp. PCC 6803 substr. PCC-N, complete genomehypothetical protein6e-1786.3
NC_017277:2746421:274939427493942749633240Synechocystis sp. PCC 6803, complete genomehypothetical protein6e-1786.3
NC_014830:4012999:402309740230974023519423Intrasporangium calvum DSM 43043 chromosome, complete genomeprotein of unknown function DUF372e-1684.3
NC_009648:4497749:449774944977494498009261Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomehypothetical protein3e-1684
NC_015968:4790239:481195348119534812210258Enterobacter asburiae LF7a chromosome, complete genomehypothetical protein3e-1684
NC_015145:4232283:424936442493644249759396Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genomehypothetical protein3e-1684
NC_018720:2138180:216599721659972166308312Bifidobacterium asteroides PRL2011 chromosome, complete genomehypothetical protein4e-1683.6
NC_004307:1620500:162660716266071626924318Bifidobacterium longum NCC2705, complete genomewidely conserved hypothetical protein with duf374e-1683.6
NC_017093:8757291:877225087722508772507258Actinoplanes missouriensis 431, complete genomehypothetical protein3e-1683.6
NC_014098:3372000:338380333838033384027225Bacillus tusciae DSM 2912 chromosome, complete genomeprotein of unknown function DUF376e-1682.8
NC_008711:4579997:459621745962174596702486Arthrobacter aurescens TC1, complete genomeputative domain of unknown function DUF379e-1682.4
NC_018531:4718904:473512647351264735611486Arthrobacter sp. Rue61a chromosome, complete genomehypothetical protein9e-1682.4
NC_011593:2819230:283179928317992832116318Bifidobacterium longum subsp. infantis ATCC 15697 chromosome,hypothetical protein8e-1682.4
NC_007498:3655304:366489636648963665105210Pelobacter carbinolicus DSM 2380, complete genomehypothetical protein8e-1682.4
NC_014210:5752651:576645357664535766776324Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,protein of unknown function DUF377e-1682.4
NC_007333:3626510:364066936406693640986318Thermobifida fusca YX, complete genomeProtein of unknown function DUF371e-1582
NC_013165:3146000:316273831627383162971234Slackia heliotrinireducens DSM 20476, complete genomeconserved hypothetical protein TIGR002781e-1582
NC_009616:1604276:161879716187971619042246Thermosipho melanesiensis BI429 chromosome, complete genomehypothetical protein1e-1582
NC_011886:4376261:439426943942694394661393Arthrobacter chlorophenolicus A6, complete genomeprotein of unknown function DUF372e-1581.6
NC_004757:427483:444123444123444332210Nitrosomonas europaea ATCC 19718, complete genomeDomain of unknown function DUF372e-1581.6
NC_008541:4679022:469750746975074697902396Arthrobacter sp. FB24 chromosome 1, complete sequenceprotein of unknown function DUF372e-1581.3
NC_018607:1313035:134026713402671340479213Brachyspira pilosicoli B2904 chromosome, complete genometoxin-antitoxin system, toxin component3e-1580.1
NC_002932:2142000:401740174268252Chlorobium tepidum TLS, complete genomehypothetical protein6e-1579.7
NC_012560:5338707:536404753640475364292246Azotobacter vinelandii DJ, complete genomehypothetical protein6e-1579.7
NC_021150:5298500:532193953219395322184246Azotobacter vinelandii CA6, complete genomehypothetical protein6e-1579.7
NC_013521:4240468:425227442522744252576303Sanguibacter keddieii DSM 10542, complete genomeconserved hypothetical protein TIGR002785e-1579.7
NC_009092:4585784:460153246015324601786255Shewanella loihica PV-4, complete genomeprotein of unknown function DUF377e-1579.3
NC_011060:3000067:301679030167903017083294Pelodictyon phaeoclathratiforme BU-1, complete genomeprotein of unknown function DUF378e-1579
NC_002947:8394:815681568401246Pseudomonas putida KT2440, complete genomeconserved hypothetical protein TIGR002781e-1478.6
NC_014220:2398334:240474824047482404954207Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeprotein of unknown function DUF371e-1478.6
NC_008578:2431074:244216824421682442500333Acidothermus cellulolyticus 11B, complete genomeprotein of unknown function DUF372e-1477.8
NC_018750:3964784:397447839744783974804327Streptomyces venezuelae ATCC 10712, complete genomeProtein YidD2e-1477.8
NC_007164:2446879:246089524608952461137243Corynebacterium jeikeium K411, complete genomehypothetical protein2e-1477.4
NC_015953:3684065:369392736939273694286360Streptomyces sp. SirexAA-E chromosome, complete genomehypothetical protein3e-1477
NC_009076:75535:103939103939104208270Burkholderia pseudomallei 1106a chromosome I, complete sequenceconserved hypothetical protein TIGR002786e-1476.3
NC_019940:1:55232228Thioflavicoccus mobilis 8321 chromosome, complete genomehypothetical protein6e-1476.3
NC_007908:4677856:471115047111504711434285Rhodoferax ferrireducens T118, complete genomeprotein of unknown function DUF377e-1475.9
NC_015161:36668:598965989660171276Deinococcus proteolyticus MRP chromosome, complete genomehypothetical protein1e-1375.1
NC_020299:764526:809131809131809340210Candidatus Kinetoplastibacterium oncopeltii TCC290E, completeconserved hypothetical protein of the DUF37 family2e-1374.7
NC_019908:641321:643232643232643432201Brachyspira pilosicoli P43/6/78 chromosome, complete genomehypothetical protein3e-1373.9
NC_019960:1658657:167551816755181675757240Prevotella dentalis DSM 3688 chromosome 1, complete sequencehypothetical protein3e-1373.9
NC_013522:736339:737681737681737908228Thermanaerovibrio acidaminovorans DSM 6589, complete genomeprotein of unknown function DUF375e-1373.2
NC_014550:3839389:385815938581593858536378Arthrobacter arilaitensis Re117, complete genomehypothetical protein1e-1272
NC_003888:4251867:427365442736544274028375Streptomyces coelicolor A3(2), complete genomehypothetical protein1e-1271.6
NC_013204:3613824:363082036308203631053234Eggerthella lenta DSM 2243, complete genomeprotein of unknown function DUF371e-1271.6
NC_013929:5135285:514273151427315143084354Streptomyces scabiei 87.22 chromosome, complete genomehypothetical protein1e-1271.6
NC_012856:3615550:364665536466553647092438Ralstonia pickettii 12D chromosome 1, complete genomeprotein of unknown function DUF372e-1271.2
NC_009615:3638451:365905036590503659271222Parabacteroides distasonis ATCC 8503 chromosome, complete genomehypothetical protein2e-1271.2
NC_003295:3688000:111011101424315Ralstonia solanacearum GMI1000, complete genomehypothetical protein2e-1270.9
NC_014228:4408500:443128544312854431479195Xenorhabdus nematophila ATCC 19061, complete genomehypothetical protein6e-1269.7
NC_008825:4025705:404310540431054043467363Methylibium petroleiphilum PM1, complete genomehypothetical protein6e-1269.3
NC_012225:1775264:177722817772281777407180Brachyspira hyodysenteriae WA1, complete genomehypothetical protein8e-1268.9
NC_006085:2544421:255909025590902559593504Propionibacterium acnes KPA171202, complete genomehypothetical protein8e-1268.9
NC_014221:398636:415344415344415607264Truepera radiovictrix DSM 17093 chromosome, complete genomeprotein of unknown function DUF372e-1168.2
NC_014833:3667748:368354936835493683812264Ruminococcus albus 7 chromosome, complete genomehypothetical protein2e-1167.8
NC_008209:1385094:138603513860351386271237Roseobacter denitrificans OCh 114, complete genomehypothetical protein3e-1167
NC_015389:2101841:211475321147532115025273Coriobacterium glomerans PW2 chromosome, complete genomeprotein of unknown function DUF374e-1167
NC_015966:2337833:236088623608862361182297Rhodothermus marinus SG0.5JP17-172 chromosome, complete genomehypothetical protein1e-1065.1
NC_015696:47484:646326463264916285Francisella sp. TX077308 chromosome, complete genomeProtein YidD2e-1064.7
NC_010161:1368500:138641513864151386765351Bartonella tribocorum CIP 105476, complete genomehypothetical protein4e-1063.5
NC_008609:1976403:199000319900031990452450Pelobacter propionicus DSM 2379, complete genomeprotein of unknown function DUF378e-1062.4
NC_015125:1597600:160522716052271605583357Microbacterium testaceum StLB037, complete genomehypothetical protein6e-0959.3
NC_014117:442616:475895475895476116222Burkholderia sp. CCGE1002 chromosome chromosome 1, completeprotein of unknown function DUF371e-0755.1
NC_012985:846202:860864860864861283420Candidatus Liberibacter asiaticus str. psy62, complete genomehypothetical protein4e-0753.5
NC_013947:2113941:214020721402072140932726Stackebrandtia nassauensis DSM 44728 chromosome, complete genomehypothetical protein7e-0752.8
NC_011883:269497:281236281236281439204Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774,protein of unknown function DUF378e-0752.4
NC_014774:995000:999416999416999730315Candidatus Liberibacter solanacearum CLso-ZC1 chromosome, completehypothetical protein2e-0651.2
NC_011832:2668337:267653126765312676671141Candidatus Methanosphaerula palustris E1-9c, complete genome6e-0649.7