Pre_GI: BLASTP Hits

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Query: NC_008593:2527064:527 Clostridium novyi NT, complete genome

Start: 527, End: 868, Length: 342

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_006448:1604627:161947216194721619807336Streptococcus thermophilus LMG 18311, complete genomeribonuclease P1e-1168.2
NC_015759:760671:780288780288780662375Weissella koreensis KACC 15510 chromosome, complete genomeribonuclease P9e-0752.4
NC_013406:7092510:711412471141247114474351Paenibacillus sp. Y412MC10 chromosome, complete genomeribonuclease P6e-1992.8
NC_006449:1606948:162178316217831622118336Streptococcus thermophilus CNRZ1066, complete genomeribonuclease P1e-1168.2
NC_009483:5113729:513563051356305135971342Geobacter uraniireducens Rf4 chromosome, complete genomeribonuclease P2e-0754.7
NC_014220:2398334:240495124049512405289339Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeribonuclease P protein component1e-0961.6
NC_009616:1604276:161843016184301618825396Thermosipho melanesiensis BI429 chromosome, complete genomeribonuclease P protein component9e-0855.5
NC_006055:769418:792445792445792777333Mesoplasma florum L1, complete genomeribonuclease P protein component4e-0650.1
NC_015519:2739347:275913427591342759505372Tepidanaerobacter sp. Re1 chromosome, complete genomeRibonuclease P protein component1e-1788.6
NC_014833:3667748:368382336838233684197375Ruminococcus albus 7 chromosome, complete genomeribonuclease P protein component7e-1475.9
NC_007929:1805000:182609118260911826432342Lactobacillus salivarius subsp. salivarius UCC118, complete genomeRibonuclease P protein component2e-1064.3
NC_011979:4293859:430390743039074304266360Geobacter sp. FRC-32, complete genomeribonuclease P protein component8e-0855.8
NC_006177:3549467:356511635651163565463348Symbiobacterium thermophilum IAM 14863, complete genomeribonuclease P protein component3e-1580.5
NC_015760:2009425:202598120259812026316336Streptococcus salivarius CCHSS3, complete genomeribonuclease P protein component2e-1167.4
NC_014392:2513529:252719325271932527552360Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomeribonuclease P protein component7e-0855.8
NC_013192:2434664:246496324649632465292330Leptotrichia buccalis DSM 1135, complete genomeribonuclease P protein component3e-0753.9
NC_015436:1:459245924942351Spirochaeta coccoides DSM 17374 chromosome, complete genomeRibonuclease P protein component6e-0649.7
NC_015690:8645500:866263886626388663003366Paenibacillus mucilaginosus KNP414 chromosome, complete genomeribonuclease P protein component2e-1994
NC_016627:4871875:489688648968864897230345Clostridium clariflavum DSM 19732 chromosome, complete genomeribonuclease P protein component8e-1785.5
NC_011898:4044500:406764740676474068012366Clostridium cellulolyticum H10, complete genomeribonuclease P protein component4e-1373.6
NC_014498:1983740:198453919845391984910372Streptococcus pneumoniae 670-6B chromosome, complete genomeribonuclease P protein component2e-1167.8
NC_016938:1830500:184506818450681845406339Melissococcus plutonius DAT561 chromosome 1, complete genomeribonuclease P protein component2e-0857.4
NC_008576:4701930:471869447186944719086393Magnetococcus sp. MC-1, complete genomeribonuclease P protein component4e-0650.1
NC_016935:8716704:873786587378658738230366Paenibacillus mucilaginosus 3016 chromosome, complete genomeribonuclease P protein component1e-1995.5
NC_015565:2879603:289135528913552891684330Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeribonuclease P protein component2e-1787.8
NC_014098:3372000:338402433840243384428405Bacillus tusciae DSM 2912 chromosome, complete genomeribonuclease P protein component2e-1374.3