Pre_GI: BLASTP Hits

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Query: NC_008593:2527064:2533304 Clostridium novyi NT, complete genome

Start: 2533304, End: 2533379, Length: 76

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:2752482:27586882758688275876376Clostridium botulinum BKT015925 chromosome, complete genometRNA-Ala5e-0753.1
NC_008593:1797000:18085601808560180863576Clostridium novyi NT, complete genometRNA-Ala5e-0753.1
NC_020291:1:14512145121458776Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genometRNA-Ala5e-0753.1
NC_004557:32094:38251382513832676Clostridium tetani E88, complete genometRNA-Ala5e-0753.1
NC_008593:2457594:25014222501422250149776Clostridium novyi NT, complete genometRNA-Ala5e-0753.1
NC_008593:2020473:20366342036634203670976Clostridium novyi NT, complete genometRNA-Ala5e-0753.1
NC_020291:6216000:62232076223207622328276Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genometRNA-Ala5e-0753.1
NC_009706:165913:17361017361017368576Clostridium kluyveri DSM 555 chromosome, complete genometRNA-Ala5e-0753.1
NC_011837:165913:17361017361017368576Clostridium kluyveri NBRC 12016, complete genometRNA-Ala5e-0753.1
NC_015425:2024154:20340232034023203409876Clostridium botulinum BKT015925 chromosome, complete genometRNA-Ala5e-0753.1
NC_015425:2277570:22892762289276228935176Clostridium botulinum BKT015925 chromosome, complete genometRNA-Ala5e-0753.1
NC_015425:2690448:27357672735767273584276Clostridium botulinum BKT015925 chromosome, complete genometRNA-Ala5e-0753.1
NC_013171:228356:23748323748323755876Anaerococcus prevotii DSM 20548, complete genometRNA-Ala2e-0651.2
NC_013171:1420135:14307591430759143083476Anaerococcus prevotii DSM 20548, complete genometRNA-Ala2e-0651.2
NC_014328:711842:71979571979571987076Clostridium ljungdahlii ATCC 49587 chromosome, complete genometRNA-Ala2e-0650.8
NC_014328:4471995:44810784481078448115376Clostridium ljungdahlii ATCC 49587 chromosome, complete genometRNA-Ala2e-0650.8
NC_014328:680085:68849568849568857076Clostridium ljungdahlii ATCC 49587 chromosome, complete genometRNA-Ala2e-0650.8
NC_009706:1:14574145741464976Clostridium kluyveri DSM 555 chromosome, complete genometRNA-Ala2e-0650.8
NC_009706:165913:17747517747517755076Clostridium kluyveri DSM 555 chromosome, complete genometRNA-Ala2e-0650.8
NC_011837:1:14574145741464976Clostridium kluyveri NBRC 12016, complete genometRNA-Ala2e-0650.8
NC_011837:165913:17747517747517755076Clostridium kluyveri NBRC 12016, complete genometRNA-Ala2e-0650.8
NC_015519:1205049:12184631218463121853876Tepidanaerobacter sp. Re1 chromosome, complete genometRNA-Ala5e-0650.1
NC_021182:4602683:46163904616390461646576Clostridium pasteurianum BC1, complete genometRNA-Ala1e-0548.9