Pre_GI: BLASTP Hits

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Query: NC_008593:2527064:2532164 Clostridium novyi NT, complete genome

Start: 2532164, End: 2532676, Length: 513

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:2752482:275756927575692758096528Clostridium botulinum BKT015925 chromosome, complete genome3H domain-containing protein1e-62238
NC_012658:1:150301503015551522Clostridium botulinum Ba4 str. 657 chromosome, complete genometranscriptional regulator, biotin repressor family3e-53207
NC_010520:1:148891488915410522Clostridium botulinum A3 str. Loch Maree, complete genomeputative transcriptional regulator4e-53206
NC_010516:1:149391493915460522Clostridium botulinum B1 str. Okra, complete genomeputative transcriptional regulator4e-53206
NC_012563:1:150921509215613522Clostridium botulinum A2 str. Kyoto, complete genometranscriptional regulator, biotin repressor family8e-53206
NC_009495:1:148951489515416522Clostridium botulinum A str. ATCC 3502 chromosome, complete genometranscriptional regulator9e-53205
NC_009697:1:149101491015431522Clostridium botulinum A str. ATCC 19397 chromosome, completetranscriptional regulator9e-53205
NC_009698:1:149101491015431522Clostridium botulinum A str. Hall chromosome, complete genometranscriptional regulator9e-53205
NC_017297:1:148861488615407522Clostridium botulinum F str. 230613 chromosome, complete genomeputative transcriptional regulator3e-52204
NC_009699:1:148201482015341522Clostridium botulinum F str. Langeland chromosome, complete genometranscriptional regulator3e-52204
NC_015687:1:152851528515800516Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein2e-50197
NC_003030:1:152851528515800516Clostridium acetobutylicum ATCC 824, complete genomeUncharacterized conserved protein, ortholog of YRXA B.subtilis2e-50197
NC_014328:1:152221522215737516Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative transcriptional regulator5e-50196
NC_004557:32094:371113711137623513Clostridium tetani E88, complete genometranscriptional regulator1e-49195
NC_009706:1:153941539415909516Clostridium kluyveri DSM 555 chromosome, complete genometranscriptional regulator4e-47186
NC_011837:1:153821538215909528Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-47186
NC_014410:2149886:216496321649632165475513Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,3H domain protein1e-42171
NC_020291:1:152081520815729522Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome3H domain-containing protein2e-42171
NC_010723:1:151751517515687513Clostridium botulinum E3 str. Alaska E43, complete genome3H domain protein1e-41168
NC_019970:2190695:220877322087732209285513Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeputative small molecule binding protein (contains 3H domain)1e-41168
NC_015555:693461:699164699164699676513Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete3H domain-containing protein2e-41168
NC_010674:1:152231522315735513Clostridium botulinum B str. Eklund 17B, complete genometranscriptional regulator4e-39160
NC_014393:1:158281582816331504Clostridium cellulovorans 743B chromosome, complete genome3H domain-containing protein4e-38157
NC_010718:2551000:258504825850482585572525Natranaerobius thermophilus JW/NM-WN-LF, complete genome3H domain protein1e-37155
NC_009922:1:163491634916867519Alkaliphilus oremlandii OhILAs, complete genome3H domain protein1e-35148
NC_017200:4240500:425313642531364253678543Bacillus thuringiensis serovar finitimus YBT-020 chromosome,putative transcriptional regulator1e-32139
NC_015737:1337605:133851213385121339066555Clostridium sp. SY8519, complete genomehypothetical protein2e-32138
NC_014377:1985714:200742120074212007930510Thermosediminibacter oceani DSM 16646 chromosome, complete genome3H domain protein2e-32138
NC_009089:1:160731607316600528Clostridium difficile 630, complete genomeputative small-molecule-binding protein2e-29128
NC_013316:1:158531585316362510Clostridium difficile R20291, complete genomeputative small-molecule-binding protein2e-28125
NC_015975:558523:582385582385582939555Lactobacillus ruminis ATCC 27782 chromosome, complete genomeputative transcriptional regulator9e-28122