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Query: NC_008593:2457594:2504456 Clostridium novyi NT, complete genome

Start: 2504456, End: 2504710, Length: 255

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_021182:93000:995389953899792255Clostridium pasteurianum BC1, complete genomepro-sigmaK processing inhibitor BofA2e-21100
NC_017297:33519:366503665036910261Clostridium botulinum F str. 230613 chromosome, complete genomesigma-K factor processing regulatory protein BofA9e-2198.6
NC_009699:33452:365823658236842261Clostridium botulinum F str. Langeland chromosome, complete genomesigma-K factor processing regulatory protein BofA9e-2198.6
NC_009698:38000:412404124041500261Clostridium botulinum A str. Hall chromosome, complete genomesigma-K factor processing regulatory protein BofA1e-2098.2
NC_009697:38000:412404124041500261Clostridium botulinum A str. ATCC 19397 chromosome, completesigma-K factor processing regulatory protein BofA1e-2098.2
NC_009495:38000:412254122541485261Clostridium botulinum A str. ATCC 3502 chromosome, complete genomesigma-K factor processing regulatory protein BofA1e-2098.2
NC_019970:35985:461404614046412273Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepro-sigmaK processing inhibitor BofA4e-1166.6
NC_014410:51711:605906059060862273Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,pro-sigmaK processing inhibitor BofA4e-1166.6
NC_015555:49842:592575925759529273Thermoanaerobacterium xylanolyticum LX-11 chromosome, completepro-sigmaK processing inhibitor BofA8e-1165.9
NC_008346:36176:390303903039296267Syntrophomonas wolfei subsp. wolfei str. Goettingen, completeSigmaK-factor processing regulatory BofA9e-0958.9
NC_017208:1:284472844728716270Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeSigmaK-factor processing regulatory protein BofA3e-0650.4
NC_014171:1:286692866928938270Bacillus thuringiensis BMB171 chromosome, complete genomesigmaK-factor processing regulatory protein BofA3e-0650.4