Pre_GI: BLASTP Hits

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Query: NC_008593:2457594:2481461 Clostridium novyi NT, complete genome

Start: 2481461, End: 2482444, Length: 984

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:2690448:271558327155832716566984Clostridium botulinum BKT015925 chromosome, complete genomeaminopeptidase M42 family endoglucanase1e-126452
NC_014328:85290:106214106214107173960Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative hydrolase3e-66252
NC_011837:3776541:379056137905613791523963Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-65248
NC_009706:3845039:385905938590593860012954Clostridium kluyveri DSM 555 chromosome, complete genomehydrolase4e-65248
NC_013156:728397:7512697512697523181050Methanocaldococcus fervens AG86, complete genomeCellulase9e-38157
NC_015636:1603664:1615097161509716161521056Methanothermococcus okinawensis IH1 chromosome, complete genomecellulase8e-36150
NC_015320:790137:7901377901377911861050Archaeoglobus veneficus SNP6 chromosome, complete genomeCellulase3e-33142
NC_011653:331986:3352393352393362461008Thermosipho africanus TCF52B, complete genomeendoglucanase M1e-29130
NC_009616:99647:1017031017031027071005Thermosipho melanesiensis BI429 chromosome, complete genomecellulase7e-29128
NC_003552:4714457:4729726472972647307721047Methanosarcina acetivorans C2A, complete genomecellulase1e-28127
NC_012785:20454:4462444624456341011Kosmotoga olearia TBF 19.5.1, complete genomepeptidase M42 family protein3e-27122
NC_014393:92500:120802120802121677876Clostridium cellulovorans 743B chromosome, complete genomepeptidase M42 family protein2e-26120
NC_016023:755237:7682087682087692991092Bacillus coagulans 36D1 chromosome, complete genomepeptidase M42 family protein3e-26119
NC_009828:1530732:1542467154246715434711005Thermotoga lettingae TMO, complete genomepeptidase M42 family protein5e-26118
NC_011772:4487378:4502354450235445034391086Bacillus cereus G9842, complete genomepeptidase, M42 family2e-25116
NC_004722:4496000:4516713451671345178041092Bacillus cereus ATCC 14579, complete genomeDeblocking aminopeptidase2e-25116
NC_003909:4333097:4354875435487543559601086Bacillus cereus ATCC 10987, complete genomepeptidase, M42 family2e-25116
NC_014033:2080818:2094491209449120955371047Prevotella ruminicola 23 chromosome, complete genomeM42 subfamily peptidase5e-25115
NC_012785:20454:4665546655476771023Kosmotoga olearia TBF 19.5.1, complete genomepeptidase M42 family protein4e-25115
NC_012785:20454:4563145631466651035Kosmotoga olearia TBF 19.5.1, complete genomepeptidase M42 family protein3e-25115
NC_008148:258292:2582922582922593441053Rubrobacter xylanophilus DSM 9941, complete genomepeptidase M427e-25114
NC_006274:4408734:4426150442615044272351086Bacillus cereus E33L, complete genomeglucanase/ deblocking aminopeptidase7e-25114
NC_008593:2457594:248274824827482483716969Clostridium novyi NT, complete genomeendoglucanase, aminopeptidase M42 family1e-24114
NC_009828:1530732:1543468154346815444871020Thermotoga lettingae TMO, complete genomepeptidase M42 family protein1e-24114
NC_009706:3845039:3860035386003538610541020Clostridium kluyveri DSM 555 chromosome, complete genomehydrolase9e-23107
NC_011837:3776541:3791537379153737925561020Clostridium kluyveri NBRC 12016, complete genomehypothetical protein9e-23107
NC_009073:803372:8033728033728044601089Pyrobaculum calidifontis JCM 11548, complete genomeCellulase8e-23107
NC_011969:4396000:4414486441448644155591074Bacillus cereus Q1 chromosome, complete genomepeptidase, m42 family7e-22104
NC_012947:3883484:3902319390231939034401122Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completepeptidase M42 family protein2e-21103
NC_012759:4467288:4467288446728844684091122Escherichia coli BW2952 chromosome, complete genomeputative endoglucanase with Zn-dependent exopeptidase domain protein2e-21103
NC_011742:4873351:4873351487335148744721122Escherichia coli S88 chromosome, complete genomeendoglucanase with Zn-dependent exopeptidase domain; KpLE2 phage-like element2e-21103
NC_010473:4630361:4630361463036146314821122Escherichia coli str. K-12 substr. DH10B, complete genomeKpLE2 phage-like element; predicted endoglucanase with Zn-dependent exopeptidase domain2e-21103
NC_000913:4528278:4528553452855345296741122Escherichia coli K12, complete genomeKpLE2 phage-like element; predicted endoglucanase with Zn-dependent exopeptidase domain2e-21103
AC_000091:4534935:4535210453521045363311122Escherichia coli W3110 DNA, complete genomepredicted endoglucanase with Zn-dependent exopeptidase domain2e-21103
NC_010184:4497473:4516796451679645178691074Bacillus weihenstephanensis KBAB4, complete genomeGlutamyl aminopeptidase2e-21103
NC_014328:85290:1041501041501051811032Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative hydrolase3e-21103
NC_012967:4510393:4510668451066845117891122Escherichia coli B str. REL606 chromosome, complete genomeputative endoglucanase with Zn-dependent exopeptidase domain2e-21103
NC_007530:4474000:4492159449215944932321074Bacillus anthracis str. 'Ames Ancestor', complete genomepeptidase, m42 family2e-21103
NC_015425:2690448:271687727168772717851975Clostridium botulinum BKT015925 chromosome, complete genomeaminopeptidase M42 family endoglucanase1e-21103
NC_011773:4541306:4555538455553845566111074Bacillus cereus AH820 chromosome, complete genomepeptidase, M42 family2e-21103
NC_012659:4474000:4492059449205944931321074Bacillus anthracis str. A0248, complete genomepeptidase, M42 family2e-21103
NC_012581:4478036:4493583449358344946561074Bacillus anthracis str. CDC 684 chromosome, complete genomepeptidase, M42 family2e-21103
NC_003997:4473973:4492032449203244931051074Bacillus anthracis str. Ames, complete genomepeptidase, M42 family2e-21103
NC_014335:4414052:4426024442602444270971074Bacillus cereus biovar anthracis str. CI chromosome, completeM42 family peptidase2e-21103
NC_005957:4472800:4487110448711044881831074Bacillus thuringiensis serovar konkukian str. 97-27, completedeblocking aminopeptidase, M42 family2e-21103
NC_005945:4473790:4492721449272144937941074Bacillus anthracis str. Sterne, complete genomepeptidase, M42 family2e-21103
NC_015474:1035834:105792710579271058919993Pyrococcus sp. NA2 chromosome, complete genomeputative endoglucanase4e-21102
NC_009616:99647:1006841006841017031020Thermosipho melanesiensis BI429 chromosome, complete genomepeptidase M42 family protein6e-21101
NC_011837:3776541:3792547379254737935901044Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-20100
NC_011772:4606000:4621582462158246226551074Bacillus cereus G9842, complete genomepeptidase, M42 family2e-20100
NC_015425:2690448:2717842271784227188611020Clostridium botulinum BKT015925 chromosome, complete genomepeptidase family M20/M25/M40 protein2e-20100
NC_017208:4662500:4676612467661246776851074Bacillus thuringiensis serovar chinensis CT-43 chromosome, completedeblocking aminopeptidase1e-20100
NC_004722:4614442:4631613463161346326861074Bacillus cereus ATCC 14579, complete genomeDeblocking aminopeptidase1e-20100
NC_011725:4636521:4655878465587846569511074Bacillus cereus B4264 chromosome, complete genomepeptidase, M42 family1e-20100
NC_009706:3845039:3861045386104538620761032Clostridium kluyveri DSM 555 chromosome, complete genomehydrolase2e-2099.8
NC_010830:757854:7596437596437607011059Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein1e-1997.1
NC_014328:85290:1051721051721061791008Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative hydrolase6e-1995.1
NC_013501:931418:9355029355029365751074Rhodothermus marinus DSM 4252, complete genomepeptidase M42 family protein2e-1894
NC_007168:1167454:1198003119800311990881086Staphylococcus haemolyticus JCSC1435, complete genomehypothetical protein2e-1893.2
NC_009828:1530732:1544490154449015455031014Thermotoga lettingae TMO, complete genomepeptidase M42 family protein3e-1892.8
NC_021175:155152:1551521551521562161065Streptococcus oligofermentans AS 1.3089, complete genomeglutamyl aminopeptidase4e-1892.4
NC_015966:2337833:2351977235197723530501074Rhodothermus marinus SG0.5JP17-172 chromosome, complete genomeCellulase4e-1892.4
NC_017353:1235095:1240875124087512419541080Staphylococcus lugdunensis N920143, complete genomeputative aminopeptidase6e-1892
NC_011146:896000:8979748979748990441071Geobacter bemidjiensis Bem, complete genomepeptidase M42 family protein2e-1789.7
NC_014393:92500:119509119509120471963Clostridium cellulovorans 743B chromosome, complete genomepeptidase M42 family protein4e-1789
NC_014624:1675500:1758928175892817600401113Eubacterium limosum KIST612 chromosome, complete genomepeptidase M42 family protein4e-1789
NC_008593:2457594:2483707248370724847261020Clostridium novyi NT, complete genomePeptidase family M20/M25/M40 protein4e-1789
NC_014393:92500:1184781184781195181041Clostridium cellulovorans 743B chromosome, complete genomepeptidase M42 family protein5e-1788.6
NC_014760:299392:2993922993923004771086Mycoplasma bovis PG45 chromosome, complete genomepeptidase, M42 family (glutamyl aminopeptidase family)8e-1788.2
NC_017342:1462297:1485358148535814864341077Staphylococcus aureus subsp. aureus TCH60 chromosome, completeglutamyl aminopeptidase1e-1687.8
NC_014973:4174668:4202909420290942039791071Geobacter sp. M18 chromosome, complete genomepeptidase M42 family protein4e-1685.9
NC_015152:1341353:1342769134276913438331065Spirochaeta sp. Buddy chromosome, complete genomeglutamyl aminopeptidase5e-1685.5
NC_011757:39881:5154351543526101068Methylobacterium chloromethanicum CM4, complete genomepeptidase M42 family protein2e-1480.1
NC_014014:397695:3997353997354008201086Mycoplasma crocodyli MP145 chromosome, complete genomeglutamyl aminopeptidase6e-1478.6
NC_009718:643200:6674666674666684941029Fervidobacterium nodosum Rt17-B1, complete genomepeptidase M42 family protein7e-1478.2
NC_010172:57500:6545065450665171068Methylobacterium extorquens PA1, complete genomepeptidase M42 family protein2e-1377
NC_014330:337546:3425953425953436621068Brachyspira pilosicoli 95/1000 chromosome, complete genomecellulase M-like protein3e-1376.3
NC_010999:2059738:2070986207098620720711086Lactobacillus casei, complete genomePeptidase M42 family2e-1273.6
NC_014963:3175912:3176640317664031788892250Terriglobus saanensis SP1PR4 chromosome, complete genomepeptidase M42 family protein3e-1272.8
NC_011653:331986:3342223342223352381017Thermosipho africanus TCF52B, complete genomeendoglucanase4e-1272.4
NC_014934:11341:2823428234293221089Cellulophaga algicola DSM 14237 chromosome, complete genomecellulase4e-1168.9
NC_015496:2436089:2439661243966124407491089Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomepeptidase M42 family protein7e-1168.2
NC_015167:313506:3274513274513285391089Cellulophaga lytica DSM 7489 chromosome, complete genomeCellulase3e-1066.2
NC_013222:2795919:2810140281014028112281089Robiginitalea biformata HTCC2501, complete genomeendoglucanase, putative6e-1065.5
NC_015703:3325780:3345175334517533462451071Runella slithyformis DSM 19594 chromosome, complete genomeCellulase9e-1064.7
NC_013730:1388333:1392765139276513938351071Spirosoma linguale DSM 74, complete genomepeptidase M42 family protein8e-0961.6