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Query: NC_008593:2457594:2477178 Clostridium novyi NT, complete genome

Start: 2477178, End: 2478074, Length: 897

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:2690448:271015727101572711029873Clostridium botulinum BKT015925 chromosome, complete genomeCAAX amino terminal protease family protein1e-76286
NC_009617:4836000:483967948396794840596918Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeabortive infection protein4e-40165
NC_020291:4815853:481878748187874819698912Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative metal-dependent membrane protease3e-34145
NC_012032:4385311:438724143872414388215975Chloroflexus sp. Y-400-fl, complete genomeAbortive infection protein2e-2099.8
NC_010175:4375265:437719543771954378169975Chloroflexus aurantiacus J-10-fl, complete genomeAbortive infection protein2e-2099.8
NC_016610:1974527:199007819900781990965888Tannerella forsythia ATCC 43037 chromosome, complete genomeCAAX amino terminal protease family protein1e-1997.1
NC_017955:3731480:374553737455373746331795Modestobacter marinus, complete genomemetal-dependent membrane protease, Abortive infection protein5e-1892
NC_009664:4377777:439699243969924397840849Kineococcus radiotolerans SRS30216, complete genomeAbortive infection protein5e-1788.6
NC_006177:1254635:127209212720921272997906Symbiobacterium thermophilum IAM 14863, complete genomehypothetical protein2e-1686.3
NC_016113:11500:292002920030033834Streptomyces cattleya NRRL 8057 plasmid pSCAT, complete sequencetransmembrane protein2e-1583.2
NC_014391:3445672:346223434622343463070837Micromonospora aurantiaca ATCC 27029 chromosome, complete genomeabortive infection protein5e-1582
NC_014334:37040:498614986150736876Lactobacillus casei str. Zhang chromosome, complete genomeputative metal-dependent membrane protease2e-1376.6
NC_017030:6912830:692410969241096925005897Corallococcus coralloides DSM 2259 chromosome, complete genomeabortive infection protein5e-1168.6
NC_007426:205390:209283209283210242960Natronomonas pharaonis DSM 2160, complete genomehypothetical protein1e-1067.8
NC_010520:725312:729436729436730347912Clostridium botulinum A3 str. Loch Maree, complete genomeCAAX amino terminal protease family protein2e-1067
NC_020207:1346579:136710113671011367940840Enterococcus faecium NRRL B-2354, complete genomehypothetical protein4e-0858.9
NC_015064:1268223:1275600127560012766161017Acidobacterium sp. MP5ACTX9 chromosome, complete genomeAbortive infection protein1e-0653.9
NC_013791:2839516:285638328563832856994612Bacillus pseudofirmus OF4 chromosome, complete genomehypothetical protein2e-0653.5