Pre_GI: BLASTP Hits

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Query: NC_008593:2457594:2465344 Clostridium novyi NT, complete genome

Start: 2465344, End: 2465985, Length: 642

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:1797000:180582818058281806469642Clostridium novyi NT, complete genomehypothetical protein7e-123439
NC_008593:2457594:247261824726182473259642Clostridium novyi NT, complete genomehypothetical protein3e-122437
NC_008593:2457594:248788224878822488523642Clostridium novyi NT, complete genomehypothetical protein3e-122437
NC_008593:2457594:249869024986902499331642Clostridium novyi NT, complete genomehypothetical protein3e-122437
NC_008593:1917118:194676319467631947404642Clostridium novyi NT, complete genomehypothetical protein3e-122437
NC_008593:2527064:253403825340382534679642Clostridium novyi NT, complete genomehypothetical protein3e-122437
NC_008593:2020473:202841420284142029055642Clostridium novyi NT, complete genomehypothetical protein3e-122437
NC_008593:1917118:192431119243111924952642Clostridium novyi NT, complete genomehypothetical protein3e-122437
NC_012563:36000:678856788568541657Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-107388
NC_012563:36000:464554645547111657Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-107388
NC_012563:36000:608806088061536657Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-107388
NC_012563:36000:530115301153667657Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-107388
NC_012563:4004709:401469040146904015346657Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein6e-107386
NC_012563:4004709:401992940199294020585657Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein6e-107386
NC_012563:519037:531896531896532552657Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein6e-107386
NC_004557:32094:390243902439680657Clostridium tetani E88, complete genomehypothetical protein1e-101368
NC_004557:162670:179742179742180398657Clostridium tetani E88, complete genomehypothetical protein1e-101368
NC_004557:558500:568913568913569569657Clostridium tetani E88, complete genomehypothetical protein1e-101368
NC_004557:1:593859386594657Clostridium tetani E88, complete genomehypothetical protein1e-101368
NC_008277:428926:4407704407704437032934Borrelia afzelii PKo, complete genome28S ribosomal RNA2e-59228
NC_008277:428926:4375334375334404662934Borrelia afzelii PKo, complete genome28S ribosomal RNA2e-59228
NC_006156:427358:4359794359794389122934Borrelia garinii PBi chromosome linear, complete sequence28S ribosomal RNA1e-58225
NC_006156:427358:4392234392234421562934Borrelia garinii PBi chromosome linear, complete sequence28S ribosomal RNA1e-58225
NC_007716:266500:275273275273275914642Aster yellows witches'-broom phytoplasma AYWB, complete genomehypothetical protein3e-51201
NC_007716:467235:493710493710494351642Aster yellows witches'-broom phytoplasma AYWB, complete genomehypothetical protein3e-51201
NC_005303:553500:560877560877561518642Onion yellows phytoplasma OY-M, complete genomehypothetical protein3e-51201
NC_005303:272915:282933282933283574642Onion yellows phytoplasma OY-M, complete genomehypothetical protein3e-51201
NC_008526:250000:2616982616982642122515Lactobacillus casei ATCC 334, complete genome23S ribosomal RNA2e-43175
NC_014752:2087998:2103651210365121062622612Neisseria lactamica ST-640, complete genome23S ribosomal RNA4e-31134
NC_015737:664999:6714546714546743482895Clostridium sp. SY8519, complete genome23S ribosomal RNA1e-29129
NC_017059:31564:411314113141445315Rhodospirillum photometricum DSM 122, complete genomehypothetical protein1e-29129
NC_005956:1402500:140973714097371410072336Bartonella henselae str. Houston-1, complete genome2e-28125
NC_005956:1572500:157974615797461580081336Bartonella henselae str. Houston-1, complete genome2e-28125
NC_013198:813830:826913826913827212300Lactobacillus rhamnosus GG, complete genomelipoprotein5e-27120
NC_013198:1921500:192679019267901927089300Lactobacillus rhamnosus GG, complete genomelipoprotein5e-27120
NC_013199:282901:293446293446293745300Lactobacillus rhamnosus Lc 705, complete genomelipoprotein5e-27120
NC_013198:298000:311420311420311719300Lactobacillus rhamnosus GG, complete genomelipoprotein5e-27120
NC_013199:1886271:189307318930731893372300Lactobacillus rhamnosus Lc 705, complete genomelipoprotein5e-27120
NC_013199:2536705:254574125457412546040300Lactobacillus rhamnosus Lc 705, complete genomelipoprotein5e-27120
NC_013199:811929:821463821463821762300Lactobacillus rhamnosus Lc 705, complete genomelipoprotein5e-27120
NC_010125:2998619:3008190300819030108092620Gluconacetobacter diazotrophicus PAl 5, complete genome23S ribosomal RNA2e-24112
NC_012438:818387:830489830489831040552Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genomehypothetical protein6e-24110
NC_012438:1514376:152296815229681523519552Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genomehypothetical protein6e-24110
NC_017059:31564:533595335954138780Rhodospirillum photometricum DSM 122, complete genomePutative glycosyl transferase (Glycosyl transferase family 2)3e-22105
NC_011144:1264871:1274525127452512773112787Phenylobacterium zucineum HLK1, complete genome23S ribosomal RNA3e-22104
NC_012440:1841315:184986418498641850433570Persephonella marina EX-H1, complete genomehypothetical protein6e-22103
NC_012440:1080675:109475510947551095324570Persephonella marina EX-H1, complete genomehypothetical protein6e-22103
NC_004369:2968251:298740729874072987607201Corynebacterium efficiens YS-314, complete genomehypothetical protein5e-1167.8
NC_004369:2968251:297853229785322979317786Corynebacterium efficiens YS-314, complete genomehypothetical protein1e-1066.6
NC_003106:1175000:1183300118330011863123013Sulfolobus tokodaii str. 7, complete genome23S ribosomal RNA1e-0653.1