Pre_GI: BLASTP Hits

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Query: NC_008593:2281896:2293515 Clostridium novyi NT, complete genome

Start: 2293515, End: 2294774, Length: 1260

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:2528549:2543822254382225450811260Clostridium botulinum BKT015925 chromosome, complete genomepyridine nucleotide-disulfide oxidoreductase0756
NC_012225:2247796:2255279225527922565531275Brachyspira hyodysenteriae WA1, complete genomepyridine nucleotide-disulphide oxidoreductase3e-146518
NC_014330:888366:8970908970908983641275Brachyspira pilosicoli 95/1000 chromosome, complete genomesarcosine oxidase subunit alpha3e-146518
NC_019908:2312194:2322020232202023232941275Brachyspira pilosicoli P43/6/78 chromosome, complete genomesarcosine oxidase subunit alpha3e-146518
NC_017243:3093393:3104177310417731054511275Brachyspira intermedia PWS/A chromosome, complete genomepyridine nucleotide-disulfide oxidoreductase4e-146518
NC_018604:2350054:2358873235887323601471275Brachyspira pilosicoli WesB complete genomesarcosine oxidase subunit alpha1e-145516
NC_018607:2231975:2240820224082022420941275Brachyspira pilosicoli B2904 chromosome, complete genomesarcosine oxidase subunit alpha7e-145513
NC_014964:557910:5670765670765683351260Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeFAD-dependent pyridine nucleotide-disulfide oxidoreductase5e-129461
NC_010321:562494:5716605716605729191260Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeFAD-dependent pyridine nucleotide-disulfide oxidoreductase5e-129461
NC_010723:1014334:1023248102324810245011254Clostridium botulinum E3 str. Alaska E43, complete genomeNAD9e-120430
NC_019978:2036779:2043585204358520448591275Halobacteroides halobius DSM 5150, complete genomethioredoxin reductase3e-118425
NC_014654:1:1944819448207281281Halanaerobium sp. 'sapolanicus' chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase3e-117422
NC_014654:1802007:1808531180853118098111281Halanaerobium sp. 'sapolanicus' chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase2e-116419
NC_014624:1675500:1725071172507117263151245Eubacterium limosum KIST612 chromosome, complete genomeputative NAD(FAD)-dependent dehydrogenase2e-104379
NC_014624:828943:8339188339188351651248Eubacterium limosum KIST612 chromosome, complete genomeputative NAD(FAD)-dependent dehydrogenase1e-94347
NC_010001:4128034:4150901415090141522231323Clostridium phytofermentans ISDg, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase1e-81303
NC_000868:269923:2780912780912793141224Pyrococcus abyssi GE5, complete genomeprobable monooxygenase5e-75281
NC_011295:246000:2629492629492641781230Coprothermobacter proteolyticus DSM 5265, complete genomesarcosine oxidase alpha subunit3e-73276
NC_006624:1208464:1213039121303912142801242Thermococcus kodakarensis KOD1, complete genomeNADH oxidase3e-70265
NC_003413:1847935:1855885185588518571261242Pyrococcus furiosus DSM 3638, complete genomeNADH oxidase2e-68259
NC_012883:695652:7024077024077036631257Thermococcus sibiricus MM 739, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase1e-63244
NC_008261:2770468:277046827704682771430963Clostridium perfringens ATCC 13124, complete genomeoxidoreductase, pyridine nucleotide-disulphide family2e-62239
NC_008262:2433979:243397924339792434941963Clostridium perfringens SM101, complete genomeoxidoreductase, pyridine nucleotide-disulphide family3e-62239
NC_003366:2556457:255645725564572557419963Clostridium perfringens str. 13, complete genomeprobable monooxygenase7e-62238
NC_017295:1036348:103634810363481037283936Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein1e-56221
NC_010674:426256:450145450145451101957Clostridium botulinum B str. Eklund 17B, complete genometRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA8e-46184
NC_010723:420025:445100445100446056957Clostridium botulinum E3 str. Alaska E43, complete genometRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA3e-44179
NC_000868:318434:3190643190643205091446Pyrococcus abyssi GE5, complete genomesarcosine oxidase, subunit alpha8e-28125
NC_015172:1075592:1106628110662811077281101Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase1e-27124
NC_014364:3001597:3025981302598130276391659Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase3e-27123
NC_003413:1666520:1667150166715016685741425Pyrococcus furiosus DSM 3638, complete genomesarcosine oxidase subunit alpha2e-25117
NC_015474:301428:3014283014283028641437Pyrococcus sp. NA2 chromosome, complete genomesarcosine oxidase, subunit alpha1e-24114
NC_013850:2357608:2365399236539923666161218Klebsiella variicola At-22 chromosome, complete genomeFAD dependent oxidoreductase2e-24113
NC_021184:2936244:2946110294611029477021593Desulfotomaculum gibsoniae DSM 7213, complete genomethioredoxin reductase4e-24112
NC_013926:71186:8670186701881371437Aciduliprofundum boonei T469 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase8e-24112
NC_016114:648422:6820406820406833111272Streptomyces flavogriseus ATCC 33331 chromosome, complete genomemonooxygenase FAD-binding protein2e-23110
NC_000961:1532245:1532245153224515336931449Pyrococcus horikoshii OT3, complete genomeD-nopaline dehydrogenase2e-23110
NC_020291:5409587:5420695542069554222721578Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase7e-23108
NC_013522:991649:1014925101492510160161092Thermanaerovibrio acidaminovorans DSM 6589, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase9e-23108
NC_015737:2691246:2691246269124626928201575Clostridium sp. SY8519, complete genomeNAD-dependent dehydrogenase2e-22107
NC_010623:1871492:1894975189497518964891515Burkholderia phymatum STM815 chromosome 2, complete sequenceFAD-dependent pyridine nucleotide-disulphide oxidoreductase2e-1274.3
NC_020210:3341976:3351474335147433525621089Geobacillus sp. GHH01, complete genomehypothetical protein3e-1273.6
NC_016641:2773757:2786959278695927881821224Paenibacillus terrae HPL-003 chromosome, complete genomehypothetical protein5e-1272.8
NC_012622:786554:7982767982767995081233Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase1e-1067.8
NC_013769:316789:3424753424753436891215Sulfolobus islandicus L.D.8.5 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase2e-1067.8
NC_017275:377800:3842483842483854621215Sulfolobus islandicus HVE10/4 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase2e-1067.8
NC_017276:337286:3445593445593457731215Sulfolobus islandicus REY15A chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase2e-1067.4
NC_002754:1061851:1064502106450210657161215Sulfolobus solfataricus P2, complete genomeToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component, probable (todA)3e-1066.6
NC_012726:346539:3536593536593548731215Sulfolobus islandicus M.16.4 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase3e-1066.6
NC_015562:1571928:1595184159518415965151332Methanotorris igneus Kol 5 chromosome, complete genomeCoA-disulfide reductase2e-0964.3
NC_003910:4234000:4240547424054742435703024Colwellia psychrerythraea 34H, complete genomesarcosine oxidase, alpha subunit2e-0963.5
NC_003910:2588000:2596916259691625999393024Colwellia psychrerythraea 34H, complete genomesarcosine oxidase, alpha subunit2e-0963.5
NC_014654:2311818:2329516232951623308621347Halanaerobium sp. 'sapolanicus' chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase3e-0963.5
NC_009708:1522281:1533506153350615351521647Yersinia pseudotuberculosis IP 31758 chromosome, complete genomepyridine nucleotide-disulfide oxidoreductase family protein6e-0962.4
NC_010465:1550617:1568109156810915697551647Yersinia pseudotuberculosis YPIII, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase6e-0962.4
NC_006155:3212796:3217167321716732188131647Yersinia pseudotuberculosis IP 32953, complete genomeputative pyridine nucleotide-disulphide oxidoreductase6e-0962.4
NC_010634:3129174:3134920313492031365661647Yersinia pseudotuberculosis PB1/+, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase1e-0861.6
NC_010159:2878499:2882870288287028845161647Yersinia pestis Angola, complete genomepyridine nucleotide-disulphide oxidoreductase family protein1e-0861.6
NC_005810:2905362:2911108291110829127541647Yersinia pestis biovar Microtus str. 91001, complete genomeputative pyridine nucleotide-disulphide oxidoreductase1e-0861.6
NC_008150:2451872:2457618245761824592641647Yersinia pestis Antiqua, complete genomeputative pyridine nucleotide-disulphide oxidoreductase1e-0861.6
NC_008149:1556581:1570342157034215719881647Yersinia pestis Nepal516, complete genomepyridine nucleotide-disulphide oxidoreductase1e-0861.6
NC_004088:1622941:1640419164041916420651647Yersinia pestis KIM, complete genomeNADH oxidase1e-0861.6
NC_003143:3346834:3352580335258033542261647Yersinia pestis CO92, complete genomeputative pyridine nucleotide-disulphide oxidoreductase1e-0861.6
NC_009381:2373847:2378218237821823798641647Yersinia pestis Pestoides F chromosome, complete genomepyridine nucleotide-disulfide oxidoreductase1e-0861.6
NC_014029:3401238:3406984340698434086301647Yersinia pestis Z176003 chromosome, complete genomeputative pyridine nucleotide-disulfide oxidoreductase1e-0861.6
NC_017154:3344273:3350019335001933516651647Yersinia pestis D106004 chromosome, complete genomeputative pyridine nucleotide-disulfide oxidoreductase1e-0861.6
NC_017160:3326199:3331945333194533335911647Yersinia pestis D182038 chromosome, complete genomeputative pyridine nucleotide-disulfide oxidoreductase1e-0861.6
NC_017168:2394079:2407840240784024094861647Yersinia pestis A1122 chromosome, complete genomeputative pyridine nucleotide-disulfide oxidoreductase1e-0861.6
NC_017265:1346685:1359580135958013612261647Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,soluble pyridine nucleotide transhydrogenase1e-0861.6
NC_012726:287637:3044033044033056261224Sulfolobus islandicus M.16.4 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase5e-0859.3
NC_012883:250758:2576022576022589301329Thermococcus sibiricus MM 739, complete genomeNADPH:elemental sulfur oxidoreductase6e-0858.9
NC_007948:4620661:4641535464153546429561422Polaromonas sp. JS666, complete genomeBFD-like (2Fe-2S)-binding region8e-0858.5
NC_010625:1370462:1392266139226613935131248Burkholderia phymatum STM815 plasmid pBPHY01, complete sequenceFAD-dependent pyridine nucleotide-disulphide oxidoreductase1e-0758.2
NC_010321:2319820:2319820231982023211781359Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeFAD-dependent pyridine nucleotide-disulfide oxidoreductase1e-0757.8
NC_014964:2301835:2301835230183523031931359Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeFAD-dependent pyridine nucleotide-disulfide oxidoreductase1e-0757.8
NC_014538:2396559:2399789239978924011471359Thermoanaerobacter sp. X513 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase2e-0757.4
NC_010320:2397395:2400625240062524019831359Thermoanaerobacter sp. X514 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase2e-0757.4
NC_013894:1194458:1207788120778812091581371Thermocrinis albus DSM 14484 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase2e-0757.4
NC_013926:920279:9228829228829241621281Aciduliprofundum boonei T469 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase2e-0757
NC_019673:6778401:6782890678289067843411452Saccharothrix espanaensis DSM 44229 complete genomeGlutamate synthase (NADH), small subunit3e-0653.5
NC_007948:4646344:4660047466004746614231377Polaromonas sp. JS666, complete genomeBFD-like (2Fe-2S)-binding region3e-0653.5
NC_013926:920279:9381929381929415093318Aciduliprofundum boonei T469 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase3e-0653.5
NC_017351:2489460:2501334250133425037392406Staphylococcus aureus subsp. aureus 11819-97 chromosome, completenitrite reductase [NAD(P)H], large subunit2e-0653.5
NC_014829:259707:2656092656092681192511Bacillus cellulosilyticus DSM 2522 chromosome, complete genomenitrite reductase (NAD(P)H), large subunit3e-0653.1
NC_017338:2456000:2466865246686524692702406Staphylococcus aureus subsp. aureus JKD6159 chromosome, completenitrite reductase, large subunit4e-0653.1
NC_015949:1887478:1903596190359619052841689Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase5e-0652.8
NC_019942:987134:1014977101497710182943318Aciduliprofundum sp. MAR08-339, complete genomeFAD binding protein,4Fe-4S protein5e-0652.8
NC_013849:1034472:1058813105881310600601248Ferroglobus placidus DSM 10642 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase5e-0652.8
NC_018866:154252:1545701545701559641395Dehalobacter sp. DCA chromosome, complete genomeDihydrolipoamide dehydrogenase4e-0652.8
NC_016941:2395502:2407584240758424099892406Staphylococcus aureus subsp. aureus MSHR1132, complete genomenitrite reductase large subunit7e-0652.4
NC_009439:574437:5940305940305954481419Pseudomonas mendocina ymp, complete genomeglutamate synthase subunit beta7e-0652.4
NC_011830:3369282:3372649337264933739081260Desulfitobacterium hafniense DCB-2, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase7e-0652.4
NC_011982:206784:2261742261742275681395Agrobacterium vitis S4 plasmid pTiS4, complete sequenceD-nopaline dehydrogenase6e-0652.4
NC_013450:2463271:2474546247454624769512406Staphylococcus aureus subsp. aureus ED98, complete genomenitrite reductase [NAD(P)H], large subunit8e-0652
NC_009632:2545419:2559075255907525614802406Staphylococcus aureus subsp. aureus JH1 chromosome, completenitrite reductase (NAD(P)H) large subunit8e-0652
NC_002745:2446722:2457997245799724604022406Staphylococcus aureus subsp. aureus N315, complete genomenitrite reductase8e-0652
NC_002953:2435667:2450570245057024529752406Staphylococcus aureus subsp. aureus MSSA476, complete genomenitrite reductase large subunit8e-0652
NC_003923:2460130:2471404247140424738092406Staphylococcus aureus subsp. aureus MW2, complete genomenitrite reductase8e-0652
NC_017337:2478877:2491044249104424934492406Staphylococcus aureus subsp. aureus ED133 chromosome, completenitrite reductase8e-0652
NC_002758:2515310:2529016252901625314212406Staphylococcus aureus subsp. aureus Mu50, complete genomenitrite reductase9e-0652
NC_009782:2519379:2530654253065425330592406Staphylococcus aureus subsp. aureus Mu3, complete genomenitrite reductase9e-0652
NC_017343:2367177:2380883238088323832882406Staphylococcus aureus subsp. aureus ECT-R 2, complete genomenitrite reductase8e-0652
NC_002951:2448000:2458510245851024609152406Staphylococcus aureus subsp. aureus COL, complete genomenitrite reductase [NAD(P)H], large subunit8e-0652
NC_007622:2399347:2410620241062024130252406Staphylococcus aureus RF122, complete genomenitrite reductase8e-0652
NC_007793:2510801:2522076252207625244812406Staphylococcus aureus subsp. aureus USA300, complete genomenitrite reductase [NAD(P)H], large subunit8e-0652
NC_010079:2510951:2522226252222625246312406Staphylococcus aureus subsp. aureus USA300_TCH1516, completenitrite reductase (NAD(P)H) large subunit8e-0652
NC_017347:2511783:2523058252305825254632406Staphylococcus aureus subsp. aureus T0131 chromosome, completeAssimilatory nitrite reductase [NAD(P)H], large subunit8e-0652
NC_017341:2544327:2555602255560225580072406Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,nitrite reductase, large subunit8e-0652
NC_016912:2329113:2340388234038823427932406Staphylococcus aureus subsp. aureus VC40 chromosome, completeassimilatory nitrite reductase [NAD(P)H], large subunit8e-0652
NC_009641:2513300:2527008252700825294132406Staphylococcus aureus subsp. aureus str. Newman chromosome,assimilatory nitrite reductase [NAD(P)H], large subunit8e-0652
NC_007795:2455468:2469175246917524715802406Staphylococcus aureus subsp. aureus NCTC 8325, complete genomeassimilatory nitrite reductase [NAD(P)H], large subunit, putative8e-0652
NC_016928:2411486:2422760242276024251652406Staphylococcus aureus subsp. aureus M013 chromosome, completeNitrite reductase large subunit9e-0652