Some Help

Query: NC_008593:1917118:1942804 Clostridium novyi NT, complete genome

Start: 1942804, End: 1943256, Length: 453

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia

SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:2144639:216849021684902168942453Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein4e-50196
NC_016627:793583:816960816960817406447Clostridium clariflavum DSM 19732 chromosome, complete genomehypothetical protein4e-30129
NC_016593:3116145:312179831217983122073276Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completehypothetical protein2e-1064.7
NC_017179:4023139:402494540249454025397453Clostridium difficile BI1, complete genomehypothetical protein3e-0753.9
NC_013315:4015119:401696140169614017377417Clostridium difficile CD196 chromosome, complete genomehypothetical protein3e-0753.9
NC_013316:4095905:409774740977474098163417Clostridium difficile R20291, complete genomehypothetical protein3e-0753.9