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Query: NC_008593:1704207:1723501 Clostridium novyi NT, complete genome

Start: 1723501, End: 1724523, Length: 1023

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_021182:2192718:2194623219462321956511029Clostridium pasteurianum BC1, complete genomeDNA polymerase III, delta subunit1e-84313
NC_012563:3374904:3395743339574333967741032Clostridium botulinum A2 str. Kyoto, complete genomeDNA polymerase III, delta subunit7e-71267
NC_009699:3178222:3199663319966332006941032Clostridium botulinum F str. Langeland chromosome, complete genomeDNA polymerase III subunit delta4e-70265
NC_009697:3071198:3092037309203730930681032Clostridium botulinum A str. ATCC 19397 chromosome, completeDNA polymerase III subunit delta2e-69263
NC_017297:3178378:319981831998183200357540Clostridium botulinum F str. 230613 chromosome, complete genome3e-40166
NC_009633:3055413:3090686309068630917261041Alkaliphilus metalliredigens QYMF chromosome, complete genomeDNA polymerase III subunit delta1e-26120
NC_007622:1558753:157645815764581577432975Staphylococcus aureus RF122, complete genomehypothetical protein1e-1997.4
NC_015519:1113095:113378711337871134731945Tepidanaerobacter sp. Re1 chromosome, complete genomeDNA polymerase III subunit delta3e-1892.8
NC_011772:4255161:4273852427385242748621011Bacillus cereus G9842, complete genomeDNA polymerase III, delta subunit3e-1686.3
NC_017208:4294341:4313051431305143140611011Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeDNA polymerase III subunit delta3e-1686.3
NC_004722:4244730:4263443426344342644531011Bacillus cereus ATCC 14579, complete genomehypothetical protein3e-1686.3
NC_011725:4288309:4307017430701743080271011Bacillus cereus B4264 chromosome, complete genomeDNA polymerase III subunit delta3e-1686.3
NC_014171:4178746:4197186419718641981961011Bacillus thuringiensis BMB171 chromosome, complete genomeDNA polymerase III subunit delta3e-1686.3
NC_010184:4155345:4175600417560041766101011Bacillus weihenstephanensis KBAB4, complete genomeDNA polymerase III, delta subunit5e-1685.5
NC_011658:4107501:4129912412991241309221011Bacillus cereus AH187 chromosome, complete genomeDNA polymerase III subunit delta3e-1583.2
NC_008600:4101748:4123960412396041249701011Bacillus thuringiensis str. Al Hakam, complete genomepossible DNA polymerase III, delta subunit3e-1582.8
NC_007530:4117071:4137069413706941380791011Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein3e-1582.8
NC_012472:4119192:4141404414140441424141011Bacillus cereus 03BB102, complete genomeDNA polymerase III, delta subunit3e-1582.8
NC_003997:4116944:4136942413694241379521011Bacillus anthracis str. Ames, complete genomehypothetical protein3e-1582.8
NC_012659:4116971:4136969413696941379791011Bacillus anthracis str. A0248, complete genomeDNA polymerase III subunit delta3e-1582.8
NC_010718:1229355:1245752124575212467561005Natranaerobius thermophilus JW/NM-WN-LF, complete genomeDNA polymerase III, delta subunit6e-1582
NC_005957:4104880:4124877412487741258871011Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-1480.1
NC_014960:3375807:337986233798623380860999Anaerolinea thermophila UNI-1, complete genomeDNA polymerase III delta subunit7e-1478.2
NC_010379:6880:103421034211325984Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequenceDNA polymerase III, delta subunit superfamily5e-1272
NC_012654:92487:976819768198664984Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequenceDNA polymerase III, delta subunit superfamily1e-1171.2
NC_010418:138325:140259140259141242984Clostridium botulinum A3 str. Loch Maree plasmid pCLK, completeDNA polymerase III, delta subunit3e-1169.7
NC_014172:53815:639546395464949996Bacillus thuringiensis BMB171 plasmid pBMB171, complete sequencehypothetical protein7e-1065.1
NC_014355:4151798:4170370417037041714641095Candidatus Nitrospira defluvii, complete genomeputative DNA polymerase III subunit delta4e-0962.4
NC_010381:92000:112513112513113445933Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequencehypothetical protein1e-0757.8
NC_014448:65000:670186701867971954Mycoplasma hyorhinis HUB-1 chromosome, complete genomehypothetical protein5e-0755.8