Pre_GI: BLASTP Hits

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Query: NC_008593:153014:166535 Clostridium novyi NT, complete genome

Start: 166535, End: 167926, Length: 1392

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:163000:1766081766081779991392Clostridium botulinum BKT015925 chromosome, complete genomeglycyl-tRNA synthetase0915
NC_014393:4541000:4555969455596945573601392Clostridium cellulovorans 743B chromosome, complete genomeglycyl-tRNA synthetase0835
NC_012658:3827500:3849719384971938511101392Clostridium botulinum Ba4 str. 657 chromosome, complete genomeglycyl-tRNA synthetase0827
NC_017297:3838189:3860431386043138618221392Clostridium botulinum F str. 230613 chromosome, complete genomeglycine--tRNA ligase0825
NC_009699:3839575:3861809386180938632001392Clostridium botulinum F str. Langeland chromosome, complete genomeglycyl-tRNA synthetase0825
NC_010516:3807780:3830028383002838314191392Clostridium botulinum B1 str. Okra, complete genomeglycyl-tRNA synthetase0824
NC_009495:3735703:3759022375902237604131392Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeglycyl-tRNA synthetase0823
NC_009697:3711692:3735011373501137364021392Clostridium botulinum A str. ATCC 19397 chromosome, completeglycyl-tRNA synthetase0823
NC_009698:3609881:3632121363212136335121392Clostridium botulinum A str. Hall chromosome, complete genomeglycyl-tRNA synthetase0823
NC_008262:2649289:2683159268315926845621404Clostridium perfringens SM101, complete genomeglycyl-tRNA synthetase0823
NC_012563:4004709:4026946402694640283371392Clostridium botulinum A2 str. Kyoto, complete genomeglycine--tRNA ligase0822
NC_010674:192951:1959821959821973731392Clostridium botulinum B str. Eklund 17B, complete genomeglycyl-tRNA synthetase0820
NC_010723:173280:1978021978021991931392Clostridium botulinum E3 str. Alaska E43, complete genomeglycyl-tRNA synthetase0819
NC_020291:117983:1446091446091460001392Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeglycine--tRNA ligase0819
NC_021182:4602683:4619327461932746207181392Clostridium pasteurianum BC1, complete genomeglycyl-tRNA synthetase, dimeric type0815
NC_014328:4471995:4488456448845644898471392Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeglycyl-tRNA synthetase0801
NC_004557:162670:1725081725081738991392Clostridium tetani E88, complete genomeglycyl-tRNA synthetase0795
NC_009706:165913:1679651679651693561392Clostridium kluyveri DSM 555 chromosome, complete genomeglycyl-tRNA synthetase0787
NC_011837:165913:1679651679651693561392Clostridium kluyveri NBRC 12016, complete genomeglycyl-tRNA synthetase0787
NC_015687:3326461:3341653334165333430411389Clostridium acetobutylicum DSM 1731 chromosome, complete genomeglycyl-tRNA synthetase0787
NC_003030:3324834:3340027334002733414151389Clostridium acetobutylicum ATCC 824, complete genomeglycyl-tRNA synthetase0787
NC_009633:3055413:3055413305541330568011389Alkaliphilus metalliredigens QYMF chromosome, complete genomeglycyl-tRNA synthetase0754
NC_016630:1610723:1624472162447216258631392Filifactor alocis ATCC 35896 chromosome, complete genomeglycine--tRNA ligase0747
NC_009012:1595498:1595498159549815968861389Clostridium thermocellum ATCC 27405, complete genomeglycyl-tRNA synthetase0732
NC_014335:4622500:4624154462415446255301377Bacillus cereus biovar anthracis str. CI chromosome, completeglycyl-tRNA synthetase0714
NC_008600:4687500:4689179468917946905551377Bacillus thuringiensis str. Al Hakam, complete genomeglycine--tRNA ligase0713
NC_005945:4670978:4674018467401846753941377Bacillus anthracis str. Sterne, complete genomeglycyl-tRNA synthetase0713
NC_012472:4691251:4692898469289846942741377Bacillus cereus 03BB102, complete genomeglycyl-tRNA synthetase0713
NC_006274:4742489:4744135474413547455111377Bacillus cereus E33L, complete genomeglycyl-tRNA synthetase0713
NC_011658:4672000:4673665467366546750411377Bacillus cereus AH187 chromosome, complete genomeglycyl-tRNA synthetase0713
NC_011773:4732457:4734104473410447354801377Bacillus cereus AH820 chromosome, complete genomeglycyl-tRNA synthetase0713
NC_011969:4613430:4615076461507646164521377Bacillus cereus Q1 chromosome, complete genomeglycyl-tRNA synthetase0713
NC_016779:4645155:4646802464680246481781377Bacillus cereus F837/76 chromosome, complete genomeGlycyl-tRNA synthetase0713
NC_017200:4697500:4698670469867047000461377Bacillus thuringiensis serovar finitimus YBT-020 chromosome,glycyl-tRNA synthetase0713
NC_014171:4740500:4740764474076447421401377Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein0710
NC_016894:2931213:2948969294896929503631395Acetobacterium woodii DSM 1030 chromosome, complete genomeglycyl-tRNA synthetase GlyS0704
NC_020134:2193900:2198808219880822001991392Clostridium stercorarium subsp. stercorarium DSM 8532, completeglycine--tRNA ligase0701
NC_011999:1320159:1320159132015913215471389Macrococcus caseolyticus JCSC5402, complete genomeglycyl-tRNA synthetase0683
NC_015519:686027:6994656994657008471383Tepidanaerobacter sp. Re1 chromosome, complete genomeglycyl-tRNA synthetase2e-178625
NC_005823:2840000:2844717284471728461111395Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130glycyl-tRNA synthetase2e-158559
NC_015732:982774:9877119877119891021392Spirochaeta caldaria DSM 7334 chromosome, complete genomeglycyl-tRNA synthetase4e-139494
NC_011728:376375:3798913798913812281338Borrelia burgdorferi ZS7, complete genomeglycyl-tRNA synthetase5e-135481
NC_016887:1680338:1698409169840916997941386Nocardia cyriacigeorgica GUH-2, complete genomeglycyl-tRNA synthetase (Glycine--tRNA ligase) (GlyRS)1e-134479
NC_001318:377039:3805553805553818921338Borrelia burgdorferi B31, complete genomeglycyl-tRNA synthetase2e-134479
NC_010612:4501414:4515981451598145173721392Mycobacterium marinum M, complete genomeglycyl-tRNA synthetase GlyS7e-134477
NC_015966:2841420:2851976285197628534211446Rhodothermus marinus SG0.5JP17-172 chromosome, complete genomeglycyl-tRNA synthetase1e-132473
NC_015848:2684275:2698286269828626996771392Mycobacterium canettii CIPT 140010059, complete genomeputative glycyl-tRNA synthetase GLYS3e-132472
NC_009525:2635792:2651641265164126530321392Mycobacterium tuberculosis H37Ra, complete genomeglycyl-tRNA synthetase3e-132472
NC_012943:1769445:1772639177263917740301392Mycobacterium tuberculosis KZN 1435 chromosome, complete genomeglycyl-tRNA synthetase3e-132472
NC_016768:1769332:1772526177252617739171392Mycobacterium tuberculosis KZN 4207 chromosome, complete genomeglycyl-tRNA synthetase glyS3e-132472
NC_015164:2111426:2113444211344421149881545Bacteroides salanitronis DSM 18170 chromosome, complete genomeglycyl-tRNA synthetase7e-132471
NC_015578:3561838:3576708357670835780961389Treponema primitia ZAS-2 chromosome, complete genomeglycine--tRNA ligase1e-131469
NC_014933:510164:5365475365475380881542Bacteroides helcogenes P 36-108 chromosome, complete genomeglycyl-tRNA synthetase1e-131469
NC_014738:1507641:1510021151002115115621542Riemerella anatipestifer ATCC 11845 = DSM 15868 chromosome,glycyl-tRNA synthetase1e-130467
NC_020125:194691:2173112173112188521542Riemerella anatipestifer RA-CH-2, complete genomeGlycyl-tRNA synthetase (class II)9e-131467
NC_019960:1198067:1226695122669512282631569Prevotella dentalis DSM 3688 chromosome 1, complete sequenceglycyl-tRNA synthetase, dimeric type3e-127455
NC_014448:487381:5074965074965088721377Mycoplasma hyorhinis HUB-1 chromosome, complete genomeGlycyl tRNA synthetase3e-126452
NC_011565:190406:1904061904061919531548Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,glycyl-tRNA synthetase6e-122437
NC_014974:758129:7581297581297596491521Thermus scotoductus SA-01 chromosome, complete genomeglycyl-tRNA synthetase8e-120431
NC_012806:105133:1153791153791167401362Mycoplasma conjunctivae, complete genomeGlycyl-tRNA synthetase6e-119427
NC_011025:313897:3138973138973152881392Mycoplasma arthritidis 158L3-1, complete genomeglycyl-tRNA synthetase1e-117424
NC_008698:235688:2557702557702572631494Thermofilum pendens Hrk 5, complete genomeglycyl-tRNA synthetase3e-104379
NC_005213:202400:3627823627823643201539Nanoarchaeum equitans Kin4-M, complete genomeglycyl-tRNA synthetase2e-86320
NC_005213:295994:3627823627823643201539Nanoarchaeum equitans Kin4-M, complete genomeglycyl-tRNA synthetase2e-86320
NC_016051:1005188:1021604102160410233131710Thermococcus sp. AM4 chromosome, complete genomeglycyl-tRNA synthetase4e-77289
NC_012622:1579927:1601503160150316032271725Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeglycyl-tRNA synthetase3e-70266
NC_015562:1081826:1097302109730210990291728Methanotorris igneus Kol 5 chromosome, complete genomeglycyl-tRNA synthetase4e-62239
NC_014122:143446:1640811640811657931713Methanocaldococcus infernus ME chromosome, complete genomeglycyl-tRNA synthetase2e-59230
NC_013407:1610221:1626805162680516285321728Methanocaldococcus vulcanius M7, complete genomeglycyl-tRNA synthetase1e-57224
NC_000909:201000:2191042191042208371734Methanocaldococcus jannaschii DSM 2661, complete genomeglycyl-tRNA synthetase9e-58224
NC_013156:431795:4317954317954335281734Methanocaldococcus fervens AG86, complete genomeglycyl-tRNA synthetase5e-57222
NC_012588:742000:7426567426567441101455Sulfolobus islandicus M.14.25 chromosome, complete genomeglycyl-tRNA synthetase2e-56220
NC_009376:1633283:1633283163328316350401758Pyrobaculum arsenaticum DSM 13514 chromosome, complete genomeglycyl-tRNA synthetase1e-55218
NC_015320:160792:1721471721471738531707Archaeoglobus veneficus SNP6 chromosome, complete genomeglycyl-tRNA synthetase1e-51204
NC_016070:1380500:1400398140039814021581761Thermoproteus tenax Kra 1, complete genomeglycyl-tRNA synthetase8e-50198
NC_015315:1684925:1684925168492516866911767Thermoproteus uzoniensis 768-20 chromosome, complete genomeglycyl-tRNA synthetase5e-48192
NC_014471:1269571:1291314129131412930711758Ignisphaera aggregans DSM 17230 chromosome, complete genomeglycyl-tRNA synthetase9e-48191
NC_015318:290849:2947062947062965681863Hippea maritima DSM 10411 chromosome, complete genomethreonyl-tRNA synthetase1e-0654.7