Pre_GI: BLASTP Hits

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Query: NC_008593:153014:163989 Clostridium novyi NT, complete genome

Start: 163989, End: 164468, Length: 480

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:163000:174106174106174561456Clostridium botulinum BKT015925 chromosome, complete genometranscription elongation factor GreA8e-68255
NC_017297:3838189:386367538636753864157483Clostridium botulinum F str. 230613 chromosome, complete genometranscription elongation factor GreA8e-61232
NC_009699:3839575:386505338650533865535483Clostridium botulinum F str. Langeland chromosome, complete genometranscription elongation factor GreA8e-61232
NC_010516:3807780:383327238332723833754483Clostridium botulinum B1 str. Okra, complete genometranscription elongation factor GreA8e-61232
NC_012563:4004709:403019040301904030672483Clostridium botulinum A2 str. Kyoto, complete genometranscription elongation factor GreA1e-60231
NC_009698:3609881:363536536353653635847483Clostridium botulinum A str. Hall chromosome, complete genometranscription elongation factor GreA2e-60231
NC_009697:3711692:373825537382553738737483Clostridium botulinum A str. ATCC 19397 chromosome, completetranscription elongation factor GreA2e-60231
NC_009495:3735703:376226637622663762748483Clostridium botulinum A str. ATCC 3502 chromosome, complete genometranscription elongation factor GreA2e-60231
NC_021182:4602683:462331946233194623801483Clostridium pasteurianum BC1, complete genometranscription elongation factor GreA2e-59227
NC_010723:173280:189795189795190277483Clostridium botulinum E3 str. Alaska E43, complete genometranscription elongation factor GreA3e-58223
NC_004557:162670:169858169858170418561Clostridium tetani E88, complete genometranscription elongation factor GreA7e-58222
NC_020291:117983:141165141165141647483Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genometranscription elongation factor GreA1e-57221
NC_003030:3324834:334348233434823343958477Clostridium acetobutylicum ATCC 824, complete genometranscription elongation factor GreA2e-57220
NC_015687:3326461:334510833451083345584477Clostridium acetobutylicum DSM 1731 chromosome, complete genometranscription elongation factor GreA2e-57220
NC_008262:2649289:268678126867812687257477Clostridium perfringens SM101, complete genometranscription elongation factor GreA3e-56217
NC_014328:4471995:449191744919174492372456Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative transcription elongation factor2e-53207
NC_009012:3421000:342416634241663424645480Clostridium thermocellum ATCC 27405, complete genometranscription elongation factor GreA2e-51200
NC_010320:819326:842047842047842520474Thermoanaerobacter sp. X514 chromosome, complete genometranscription elongation factor GreA6e-48189
NC_009089:4140764:415423441542344154713480Clostridium difficile 630, complete genometranscription elongation factor1e-47188
NC_013316:4018451:403255640325564033035480Clostridium difficile R20291, complete genometranscription elongation factor grea1e-47188
NC_014393:4541000:455994645599464560422477Clostridium cellulovorans 743B chromosome, complete genometranscription elongation factor GreA3e-47187
NC_009922:490500:505333505333505812480Alkaliphilus oremlandii OhILAs, complete genometranscription elongation factor GreA1e-46184
NC_018664:2459994:247645724764572476933477Clostridium acidurici 9a chromosome, complete genometranscription elongation factor GreA5e-46182
NC_015555:277364:293664293664294137474Thermoanaerobacterium xylanolyticum LX-11 chromosome, completetranscription elongation factor GreA5e-46182
NC_015519:245036:247769247769248245477Tepidanaerobacter sp. Re1 chromosome, complete genometranscription elongation factor GreA1e-44178
NC_011898:426951:448093448093448569477Clostridium cellulolyticum H10, complete genometranscription elongation factor GreA2e-44177
NC_014377:149288:156753156753157229477Thermosediminibacter oceani DSM 16646 chromosome, complete genomeGreA/GreB family elongation factor2e-40164
NC_016894:1092005:109614710961471096629483Acetobacterium woodii DSM 1030 chromosome, complete genometranscription elongation factor GreA7e-40162
NC_007907:225948:234379234379234849471Desulfitobacterium hafniense Y51, complete genomehypothetical protein1e-39161
NC_015565:173774:179285179285179761477Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completetranscription elongation factor GreA2e-39160
NC_007503:2098980:212128221212822121755474Carboxydothermus hydrogenoformans Z-2901, complete genometranscription elongation factor GreA4e-39160
NC_014831:149626:155894155894156373480Thermaerobacter marianensis DSM 12885 chromosome, complete genometranscription elongation factor GreA2e-38158
NC_016584:85543:914739147391943471Desulfosporosinus orientis DSM 765 chromosome, complete genometranscription elongation factor GreA2e-38157
NC_009454:259022:262834262834263310477Pelotomaculum thermopropionicum SI, complete genometranscription elongation factor4e-38156
NC_014378:131810:133032133032133505474Acetohalobium arabaticum DSM 5501 chromosome, complete genometranscription elongation factor GreA7e-38155
NC_018867:361423:365767365767366237471Dehalobacter sp. CF chromosome, complete genomeTranscription elongation factor GreA2e-37154
NC_014654:2138794:215410021541002154582483Halanaerobium sp. 'sapolanicus' chromosome, complete genometranscription elongation factor GreA4e-36150
NC_019903:83857:939689396894438471Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,transcription elongation factor GreA5e-36149
NC_010718:128423:133411133411133905495Natranaerobius thermophilus JW/NM-WN-LF, complete genometranscription elongation factor GreA2e-35147
NC_015977:3324000:334119633411963341681486Roseburia hominis A2-183 chromosome, complete genometranscription elongation factor GreA5e-35146
NC_011772:4321117:432379843237984324325528Bacillus cereus G9842, complete genometranscription elongation factor GreA6e-35146
NC_010184:4219257:422221142222114222738528Bacillus weihenstephanensis KBAB4, complete genometranscription elongation factor GreA3e-34144
NC_017200:4191963:419713941971394197666528Bacillus thuringiensis serovar finitimus YBT-020 chromosome,transcription elongation factor GreA3e-34144
NC_014335:4113154:411750441175044118031528Bacillus cereus biovar anthracis str. CI chromosome, completetranscription elongation factor2e-34144
NC_011658:4171237:417659341765934177069477Bacillus cereus AH187 chromosome, complete genometranscription elongation factor GreA2e-34144
NC_011969:4065460:407195340719534072429477Bacillus cereus Q1 chromosome, complete genometranscription elongation factor grea2e-34144
NC_007530:4176462:418581541858154186291477Bacillus anthracis str. 'Ames Ancestor', complete genometranscription elongation factor GreA2e-34144
NC_005957:4169610:417497241749724175448477Bacillus thuringiensis serovar konkukian str. 97-27, completetranscription elongation factor GreA2e-34144
NC_020995:2255521:225885522588552259334480Enterococcus casseliflavus EC20, complete genometranscription elongation factor greA3e-33140
NC_003485:316679:337232337232337762531Streptococcus pyogenes MGAS8232, complete genometranscription elongation factor GreA2e-29128
NC_013895:1086500:109919910991991099681483Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completetranscription elongation factor GreA2e-28124
NC_011146:2200142:220350022035002203976477Geobacter bemidjiensis Bem, complete genometranscription elongation factor GreA4e-26117
NC_012918:2668031:268448226844822684958477Geobacter sp. M21 chromosome, complete genometranscription elongation factor GreA1e-25115
NC_014960:1735786:178532517853251785792468Anaerolinea thermophila UNI-1, complete genometranscription elongation factor GreA2e-25114
NC_015738:838715:853221853221853691471Eggerthella sp. YY7918, complete genomehypothetical protein1e-24112
NC_005296:4574213:461225246122524612728477Rhodopseudomonas palustris CGA009, complete genometranscription elongation factor GreA2e-24111
NC_011004:4947980:496777749677774968253477Rhodopseudomonas palustris TIE-1, complete genometranscription elongation factor GreA2e-24111
NC_012880:3915500:392881439288143929290477Dickeya dadantii Ech703, complete genometranscription elongation factor GreA3e-23107
NC_015389:1610756:162599316259931626466474Coriobacterium glomerans PW2 chromosome, complete genometranscription elongation factor GreA4e-23107
NC_010830:923266:943068943068943541474Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein2e-22104
NC_015318:1151422:117480011748001175270471Hippea maritima DSM 10411 chromosome, complete genometranscription elongation factor GreA6e-22103
NC_016893:563890:568045568045568521477Wigglesworthia glossinidia endosymbiont of Glossina morsitanstranscription elongation factor7e-22102
NC_019814:320260:332304332304332780477Candidatus Kinetoplastibacterium blastocrithidii (ex Strigomonastranscription elongation factor GreA1e-21102
NC_019904:186056:197731197731198204474Echinicola vietnamensis DSM 17526 chromosome, complete genometranscription elongation factor GreA1e-21102
NC_007759:623116:635172635172635657486Syntrophus aciditrophicus SB, complete genometranscription elongation factor1e-21102
NC_019815:782987:791359791359791835477Candidatus Kinetoplastibacterium crithidii (ex Angomonas deaneitranscription elongation factor GreA2e-21101
NC_020299:149118:161146161146161622477Candidatus Kinetoplastibacterium oncopeltii TCC290E, completetranscription elongation factor GreA5e-21100
NC_015422:2806832:280798628079862808462477Alicycliphilus denitrificans K601 chromosome, complete genometranscription elongation factor GreA3e-21100
NC_012560:4311906:433028243302824330758477Azotobacter vinelandii DJ, complete genomeProkaryotic transcription elongation factor GreA3e-21100
NC_021150:4311902:433027843302784330754477Azotobacter vinelandii CA6, complete genometranscription elongation factor GreA3e-21100
NC_017259:388000:407534407534408013480Buchnera aphidicola str. Ua (Uroleucon ambrosiae) chromosome,transcription elongation factor GreA2e-2098.2
NC_016811:2903871:292463829246382925120483Legionella pneumophila subsp. pneumophila ATCC 43290 chromosome,transcription elongation factor GreA2e-2098.2
NC_002942:2943206:296397329639732964455483Legionella pneumophila subsp. pneumophila str. Philadelphia 1,transcription elongation factor GreA2e-2098.2
NC_006368:3028286:305123230512323051714483Legionella pneumophila str. Paris, complete genometranscription elongation factor GreA2e-2098.2
NC_004129:957890:963439963439963915477Pseudomonas fluorescens Pf-5, complete genometranscription elongation factor GreA2e-2098.2
NC_009494:3119997:314076331407633141245483Legionella pneumophila str. Corby chromosome, complete genometranscription elongation factor GreA2e-2097.8
NC_004344:257471:274883274883275359477Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis,hypothetical protein3e-2097.4
NC_014125:3054000:307473530747353075202468Legionella pneumophila 2300/99 Alcoy chromosome, complete genometranscription elongation factor GreA3e-2097.4
NC_013416:939668:941271941271941747477Aggregatibacter actinomycetemcomitans D11S-1, complete genometranscription elongation factor GreA3e-2097.4
NC_010524:3094303:310650431065043106980477Leptothrix cholodnii SP-6, complete genometranscription elongation factor GreA4e-2097.1
NC_020075:114790:116759116759117235477Candidatus Blochmannia chromaiodes str. 640, complete genometranscription elongation factor GreA5e-2096.7
NC_007292:113396:116889116889117365477Candidatus Blochmannia pennsylvanicus str. BPEN, complete genometranscription elongation factor7e-2096.3
NC_010519:1684901:168490116849011685377477Haemophilus somnus 2336 chromosome, complete genometranscription elongation factor GreA1e-1995.9
NC_017243:2190000:220210222021022202566465Brachyspira intermedia PWS/A chromosome, complete genometranscription elongation factor GreA2e-1995.1
NC_011025:183287:190603190603191082480Mycoplasma arthritidis 158L3-1, complete genometranscription elongation factor2e-1994.7
NC_015968:4117835:416070141607014161177477Enterobacter asburiae LF7a chromosome, complete genometranscription elongation factor GreA3e-1994.4
NC_020063:528296:528296528296528772477Enterobacteriaceae bacterium strain FGI 57, complete genometranscription elongation factor GreA3e-1994.4
NC_010278:1045884:104948910494891049965477Actinobacillus pleuropneumoniae serovar 3 str. JL03 chromosome,transcription elongation factor GreA3e-1994
NC_009053:1081651:108525610852561085732477Actinobacillus pleuropneumoniae L20, complete genometranscription elongation factor GreA3e-1994
NC_006833:409599:414560414560415054495Wolbachia endosymbiont strain TRS of Brugia malayi, completeTranscription elongation factor, GreA1e-1892.4
NC_013716:4885776:489403748940374894513477Citrobacter rodentium ICC168, complete genometranscription elongation factor1e-1892
NC_015275:1:162381623816705468Clostridium lentocellum DSM 5427 chromosome, complete genometranscription elongation factor GreA2e-1891.7
NC_009465:813816:831932831932832411480Candidatus Vesicomyosocius okutanii HA, complete genometranscription elongation factor GreA2e-1891.3
NC_002528:404545:424946424946425425480Buchnera aphidicola str. APS (Acyrthosiphon pisum), completetranscription elongation factor GreA2e-1891.3
NC_010981:1243888:126900012690001269494495Wolbachia pipientis, complete genometranscription elongation factor GreA3e-1890.9
NC_004545:392685:406178406178406657480Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genometranscription elongation factor GreA4e-1890.5
NC_005061:96536:104321104321104809489Candidatus Blochmannia floridanus, complete genometranscription elongation factor, cleaves 3' nucleotide of paused mRNA4e-1890.5
NC_002978:618723:641759641759642253495Wolbachia endosymbiont of Drosophila melanogaster, complete genometranscription elongation factor GreA2e-1788.2
NC_012416:531772:536755536755537249495Wolbachia sp. wRi, complete genometranscription elongation factor GreA3e-1787.8
NC_004842:1031020:105108510510851051609525Anaplasma marginale str. St. Maries, complete genometranscription elongation factor greA6e-1786.3
NC_002162:333303:348924348924349394471Ureaplasma parvum serovar 3 str. ATCC 700970, complete genometranscription elongation factor7e-1786.3
NC_012806:818592:833987833987834472486Mycoplasma conjunctivae, complete genomeTranscription elongation factor3e-1684.3
NC_014909:86000:108865108865109347483Candidatus Blochmannia vafer str. BVAF chromosome, complete genometranscription elongation factor GreA5e-1683.6
NC_013124:1606879:160831316083131608795483Acidimicrobium ferrooxidans DSM 10331, complete genomeGreA/GreB family elongation factor5e-1580.1
UCMB5137:2054735:210279621027962103260465Bacillus atrophaeus UCMB-5137transcription elongation factor GreA1e-1272.4
NC_016111:4115097:411698941169894117486498Streptomyces cattleya NRRL 8057, complete genomeTranscription elongation factor greA1e-1272.4
NC_000919:12545:215582155822046489Treponema pallidum subsp. pallidum str. Nichols, complete genometranscription elongation factor (greA)4e-1270.5
NC_010741:12542:215552155522043489Treponema pallidum subsp. pallidum SS14, complete genometranscription elongation factor GreA4e-1270.5
NC_021508:12543:1936819368220492682Treponema pallidum subsp. pallidum SS14, complete genometranscription elongation factor GreA7e-1269.7
NC_016844:12545:1937019370220512682Treponema pallidum subsp. pallidum DAL-1 chromosome, completetranscription elongation factor GreA7e-1269.7
NC_017268:1:1937119371220522682Treponema pallidum subsp. pallidum str. Chicago chromosome,7e-1269.7
NC_016842:1:1937319373220542682Treponema pallidum subsp. pertenue str. SamoaD chromosome, completetranscription elongation factor GreA7e-1269.7
NC_016843:1:1937319373220542682Treponema pallidum subsp. pertenue str. Gauthier chromosome,transcription elongation factor GreA7e-1269.7
NC_016848:12548:1937319373220542682Treponema pallidum subsp. pertenue str. CDC2 chromosome, completetranscription elongation factor GreA7e-1269.7
NC_017271:3057161:306004130600413060547507Xanthomonas campestris pv. raphani 756C chromosome, completetranscription elongation factor GreB1e-1168.9
NC_008095:3719441:373264237326423733172531Myxococcus xanthus DK 1622, complete genometranscription elongation factor GreB2e-1064.7
NC_015554:4824000:483108048310804831559480Alteromonas sp. SN2 chromosome, complete genometranscription elongation factor GreB4e-1063.9
NC_009052:144619:155332155332155841510Shewanella baltica OS155, complete genometranscription elongation factor GreB9e-1062.8
NC_009654:4253431:425643942564394257029591Marinomonas sp. MWYL1, complete genometranscription elongation factor GreB1e-0962
NC_012997:3185248:320821132082113208729519Teredinibacter turnerae T7901, complete genometranscription elongation factor GreB1e-0962
NC_008710:108057:1278651278651305672703Borrelia turicatae 91E135, complete genometranscription elongation factor GreA2e-0858.2
NC_015580:3252534:325459032545903255069480Novosphingobium sp. PP1Y, complete genomeGreA/GreB family elongation factor3e-0857.8
NC_015572:3091707:311880131188013119283483Methylomonas methanica MC09 chromosome, complete genometranscription elongation factor GreB3e-0857.8
NC_008322:4611000:461745746174574617942486Shewanella sp. MR-7, complete genometranscription elongation factor GreB3e-0857.4
NC_017093:835260:855594855594856088495Actinoplanes missouriensis 431, complete genomeputative transcription elongation factor3e-0857.4
NC_014484:1163576:1198728119872812014242697Spirochaeta thermophila DSM 6192 chromosome, complete genomehypothetical protein4e-0857.4
NC_008343:2020785:203505320350532035562510Granulibacter bethesdensis CGDNIH1, complete genometranscription elongation factor greB1e-0755.8
NC_010673:113133:1281021281021308072706Borrelia hermsii DAH, complete genometranscription elongation factor GreA1e-0755.5
NC_006370:166000:187189187189187659471Photobacterium profundum SS9 chromosome 1, complete sequencetranscription elongation factor GreB1e-0755.5
NC_011992:889985:889985889985890545561Acidovorax ebreus TPSY, complete genometranscription elongation factor GreB2e-0755.1
NC_008752:3955327:395767839576783958244567Acidovorax avenae subsp. citrulli AAC00-1, complete genometranscription elongation factor GreB2e-0755.1
NC_013730:1342500:135503013550301355545516Spirosoma linguale DSM 74, complete genomeGreA/GreB family elongation factor2e-0754.7
NC_008825:2889933:289348728934872894128642Methylibium petroleiphilum PM1, complete genometranscription elongation factor6e-0753.5
NC_014623:6950638:695431569543156954749435Stigmatella aurantiaca DW4/3-1 chromosome, complete genometranscription elongation factor2e-0651.6
NC_013166:82986:107723107723108133411Kangiella koreensis DSM 16069, complete genomeGreA/GreB family elongation factor2e-0651.6
NC_014220:1162948:117444811744481174900453Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeGreA/GreB family elongation factor2e-0651.2
NC_012704:652589:673314673314673820507Corynebacterium kroppenstedtii DSM 44385, complete genomeTranscription elongation factor3e-0650.8