Pre_GI: BLASTP Hits

Some Help

Query: NC_008593:153014:162007 Clostridium novyi NT, complete genome

Start: 162007, End: 162786, Length: 780

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia



SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:163000:172039172039172824786Clostridium botulinum BKT015925 chromosome, complete genomeputative Baf family transcriptional acitvator1e-138492
NC_017297:3838189:386614638661463866922777Clostridium botulinum F str. 230613 chromosome, complete genometranscriptional activator, Baf family protein5e-116417
NC_009699:3839575:386752438675243868300777Clostridium botulinum F str. Langeland chromosome, complete genomepantothenate kinase5e-116417
NC_009698:3609881:363783636378363638612777Clostridium botulinum A str. Hall chromosome, complete genomepantothenate kinase5e-116417
NC_009697:3711692:374072637407263741502777Clostridium botulinum A str. ATCC 19397 chromosome, completepantothenate kinase5e-116417
NC_009495:3735703:376473737647373765513777Clostridium botulinum A str. ATCC 3502 chromosome, complete genomepantothenate kinase5e-116417
NC_010516:3807780:383574338357433836519777Clostridium botulinum B1 str. Okra, complete genometranscriptional activator, Baf family5e-116417
NC_012563:4004709:403266140326614033437777Clostridium botulinum A2 str. Kyoto, complete genomepantothenate kinase, type III5e-116417
NC_014328:4471995:449441744944174495196780Clostridium ljungdahlii ATCC 49587 chromosome, complete genometype III pantothenate kinase6e-110397
NC_021182:4602683:462505246250524625858807Clostridium pasteurianum BC1, complete genomepantothenate kinase, type III8e-110396
NC_004557:162670:167196167196167984789Clostridium tetani E88, complete genomeputative transcriptional regulator5e-109394
NC_003030:3324834:334507233450723345893822Clostridium acetobutylicum ATCC 824, complete genomePredicted transcriptional regulator, homolog of Bvg accessory factor2e-105381
NC_015687:3326461:334669833466983347519822Clostridium acetobutylicum DSM 1731 chromosome, complete genomepantothenate kinase2e-105381
NC_008262:2649289:268852326885232689302780Clostridium perfringens SM101, complete genometranscriptional activator, putative5e-100363
NC_014393:4541000:456157045615704562349780Clostridium cellulovorans 743B chromosome, complete genomeputative transcriptional acitvator, Baf family8e-97353
NC_020291:117983:139042139042139836795Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genometype III pantothenate kinase CoaX4e-95347
NC_010723:173280:187044187044187817774Clostridium botulinum E3 str. Alaska E43, complete genometype III pantothenate kinase4e-93340
NC_015949:1887478:188747818874781888266789Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomeputative Baf family transcriptional acitvator4e-89327
NC_018664:2459994:247935124793512480118768Clostridium acidurici 9a chromosome, complete genomepantothenate kinase type III4e-89327
NC_015555:277364:285858285858286631774Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeputative transcriptional acitvator, Baf family1e-88326
NC_010320:819326:834297834297835064768Thermoanaerobacter sp. X514 chromosome, complete genomepantothenate kinase2e-88325
NC_015958:2361551:236429923642992365066768Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeputative Baf family transcriptional acitvator3e-88324
NC_009454:259022:259022259022259792771Pelotomaculum thermopropionicum SI, complete genomepantothenate kinase1e-86319
NC_017208:64500:715167151672304789Bacillus thuringiensis serovar chinensis CT-43 chromosome, completepantothenate kinase5e-86317
NC_009922:490500:502101502101502898798Alkaliphilus oremlandii OhILAs, complete genomeputative transcriptional acitvator, Baf family5e-86317
NC_013316:4018451:403424940342494035019771Clostridium difficile R20291, complete genomehypothetical protein1e-85316
NC_009089:4140764:415592741559274156697771Clostridium difficile 630, complete genomehypothetical protein2e-85315
NC_014171:71963:719637196372751789Bacillus thuringiensis BMB171 chromosome, complete genomepantothenate kinase5e-85313
NC_015565:173774:175982175982176914933Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeputative Baf family transcriptional acitvator8e-84310
NC_016584:85543:895008950090267768Desulfosporosinus orientis DSM 765 chromosome, complete genomepantothenate kinase, type III3e-81301
NC_007907:225948:232420232420233196777Desulfitobacterium hafniense Y51, complete genomehypothetical protein2e-77288
NC_019903:83857:919919199192767777Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,pantothenate kinase3e-77288
NC_018867:361423:362339362339363106768Dehalobacter sp. CF chromosome, complete genomePantothenate kinase type III, CoaX-like protein3e-76285
NC_014654:2138794:215572721557272156500774Halanaerobium sp. 'sapolanicus' chromosome, complete genomeputative transcriptional acitvator, Baf family5e-76284
NC_020134:2832857:285426828542682855038771Clostridium stercorarium subsp. stercorarium DSM 8532, completetype III pantothenate kinase CoaX2e-75281
NC_007503:2098980:212453621245362125309774Carboxydothermus hydrogenoformans Z-2901, complete genomepuatative transcriptional activator, Baf family7e-75280
NC_018665:71677:716777167772438762Exiguobacterium antarcticum B7 chromosome, complete genomeType III pantothenate kinase4e-74277
NC_010556:71776:717767177672537762Exiguobacterium sibiricum 255-15, complete genomeputative transcriptional acitvator, Baf family7e-74276
NC_004193:79588:837318373184498768Oceanobacillus iheyensis HTE831, complete genomehypothetical protein7e-70263
NC_015977:3324000:334329033432903344078789Roseburia hominis A2-183 chromosome, complete genomepantothenate kinase2e-69261
NC_018704:81733:861088610886875768Amphibacillus xylanus NBRC 15112, complete genometype III pantothenate kinase3e-64244
NC_015953:3159234:317491831749183175715798Streptomyces sp. SirexAA-E chromosome, complete genometranscriptional activator, Baf family1e-62239
NC_014314:238043:240297240297241064768Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completeBaf family transcriptional activator1e-61236
NC_014831:149626:152887152887153723837Thermaerobacter marianensis DSM 12885 chromosome, complete genomepantothenate kinase1e-57223
NC_008358:1789816:180203718020371802804768Hyphomonas neptunium ATCC 15444, complete genomeputative transcriptional activator, Baf family2e-55216
NC_013159:3858425:387191738719173872723807Saccharomonospora viridis DSM 43017, complete genomepantothenate kinase4e-55214
NC_013721:1204566:121324512132451214012768Gardnerella vaginalis 409-05, complete genomepantothenate kinase5e-54211
NC_019673:359540:366502366502367287786Saccharothrix espanaensis DSM 44229 complete genomeType III pantothenate kinase1e-53209
NC_015709:1459838:146359014635901464417828Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completeputative Baf family transcriptional acitvator2e-48192
NC_014833:1488994:150783115078311508595765Ruminococcus albus 7 chromosome, complete genomeputative transcriptional acitvator, Baf family3e-46185
NC_015732:1507473:151084515108451511606762Spirochaeta caldaria DSM 7334 chromosome, complete genomeputative transcriptional acitvator, Baf family7e-46184
NC_015682:1457004:147079914707991471563765Thermodesulfobacterium sp. OPB45 chromosome, complete genomeputative transcriptional acitvator, Baf family6e-45181
NC_015696:610000:616873616873617649777Francisella sp. TX077308 chromosome, complete genomePantothenate kinase type III, CoaX-like protein4e-42171
NC_014363:114239:117954117954118748795Olsenella uli DSM 7084 chromosome, complete genomepantothenate kinase2e-37156
NC_013730:7743954:774717877471787747960783Spirosoma linguale DSM 74, complete genomeputative transcriptional acitvator, Baf family1e-35150
NC_014844:511552:533193533193533963771Desulfovibrio aespoeensis Aspo-2 chromosome, complete genometranscriptional activator, Baf family2e-33142
NC_010655:1160384:116467911646791165407729Akkermansia muciniphila ATCC BAA-835, complete genomeputative transcriptional acitvator, Baf family2e-28125
NC_007205:841818:863860863860864606747Candidatus Pelagibacter ubique HTCC1062, complete genomeBvg accessory factor9e-24110
NC_013730:1572889:159326315932631594069807Spirosoma linguale DSM 74, complete genomeputative transcriptional acitvator, Baf family3e-1479
NC_008340:480399:496048496048496818771Alkalilimnicola ehrlichei MLHE-1, complete genomeputative transcriptional acitvator, Baf family1e-1376.6
NC_014041:661352:682557682557683291735Zunongwangia profunda SM-A87 chromosome, complete genomepantothenate kinase2e-1376.6
NC_006908:711050:725838725838726569732Mycoplasma mobile 163K, complete genomeputative transcriptional regulator2e-1066.6
NC_018604:2350054:236303323630332363815783Brachyspira pilosicoli WesB complete genomepantothenate kinase2e-1066.2
NC_018607:2231975:224498022449802245762783Brachyspira pilosicoli B2904 chromosome, complete genomepantothenate kinase2e-1066.2
NC_019908:2312194:231835123183512319133783Brachyspira pilosicoli P43/6/78 chromosome, complete genomepantothenate kinase2e-1066.2
NC_014330:888366:901252901252902034783Brachyspira pilosicoli 95/1000 chromosome, complete genomepantothenate kinase2e-1066.2
NC_017514:96911:1206251206251224031779Neisseria meningitidis M01-240149 chromosome, complete genomebiotin-(acetyl-CoA-carboxylase) ligase/transcriptional activator, Baf family4e-1065.5
NC_004663:5741436:575827257582725758940669Bacteroides thetaiotaomicron VPI-5482, complete genomeputative transcription regulator4e-1065.5
NC_009925:1109770:112711411271141127851738Acaryochloris marina MBIC11017, complete genometype III pantothenate kinase, putative3e-0962.4
NC_015381:4070968:407306540730654073868804Burkholderia gladioli BSR3 chromosome 1, complete sequencePutative transcriptional acitvator, Baf family protein1e-0757
NC_002516:4747154:478673447867344787480747Pseudomonas aeruginosa PAO1, complete genomehypothetical protein2e-0756.2
NC_008789:942309:946900946900947664765Halorhodospira halophila SL1, complete genomeputative transcriptional acitvator, Baf family4e-0755.5
NC_007520:2128178:213448921344892135235747Thiomicrospira crunogena XCL-2, complete genomeputative transcriptional acitvator, Baf9e-0754.3
NC_015731:2950874:296024629602462960980735Nitrosomonas sp. Is79A3 chromosome, complete genomeputative transcriptional acitvator, Baf family1e-0653.9
NC_007604:1875268:187621618762161876959744Synechococcus elongatus PCC 7942, complete genomeputative transcriptional acitvator, Baf2e-0653.1
NC_006576:2423250:244009224400922440835744Synechococcus elongatus PCC 6301, complete genomehypothetical protein7e-0651.2