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Query: NC_008593:153014:160213 Clostridium novyi NT, complete genome

Start: 160213, End: 161883, Length: 1671

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:163000:1702501702501719201671Clostridium botulinum BKT015925 chromosome, complete genomeformate--tetrahydrofolate ligase0963
NC_015687:3326461:3347608334760833492781671Clostridium acetobutylicum DSM 1731 chromosome, complete genomeformate--tetrahydrofolate ligase0915
NC_003030:3324834:3345982334598233476521671Clostridium acetobutylicum ATCC 824, complete genomeFormate--tetrahydrofolate ligase0915
NC_008262:2649289:2689505268950526911751671Clostridium perfringens SM101, complete genomeformate--tetrahydrofolate ligase0874
NC_021182:4602683:4626031462603146277011671Clostridium pasteurianum BC1, complete genomeformyltetrahydrofolate synthetase0858
NC_020291:117983:1371881371881388581671Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeformate--tetrahydrofolate ligase Fhs0857
NC_010516:3807780:3836674383667438383471674Clostridium botulinum B1 str. Okra, complete genomeformate--tetrahydrofolate ligase0856
NC_009699:3839575:3868455386845538701281674Clostridium botulinum F str. Langeland chromosome, complete genomeformate--tetrahydrofolate ligase0856
NC_017297:3838189:3867077386707738687501674Clostridium botulinum F str. 230613 chromosome, complete genomeformate--tetrahydrofolate ligase0856
NC_009698:3609881:3638767363876736404401674Clostridium botulinum A str. Hall chromosome, complete genomeformate--tetrahydrofolate ligase0854
NC_009697:3711692:3741657374165737433301674Clostridium botulinum A str. ATCC 19397 chromosome, completeformate--tetrahydrofolate ligase0854
NC_009495:3735703:3765668376566837673411674Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeformate--tetrahydrofolate ligase0854
NC_014393:4541000:4562623456262345642931671Clostridium cellulovorans 743B chromosome, complete genomeFormate--tetrahydrofolate ligase0853
NC_012563:4004709:4033592403359240352651674Clostridium botulinum A2 str. Kyoto, complete genomeformate--tetrahydrofolate ligase0851
NC_010723:173280:1852521852521869221671Clostridium botulinum E3 str. Alaska E43, complete genomeformate--tetrahydrofolate ligase0847
NC_015555:277364:2808562808562825411686Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeFormate--tetrahydrofolate ligase0773
NC_015958:2361551:2372086237208623737531668Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeFormate--tetrahydrofolate ligase0762
NC_010320:819326:8290188290188306851668Thermoanaerobacter sp. X514 chromosome, complete genomeformate--tetrahydrofolate ligase0761
NC_014376:1217000:1233224123322412348941671Clostridium saccharolyticum WM1 chromosome, complete genomeFormate--tetrahydrofolate ligase0760
NC_003869:2267627:2278072227807222797511680Thermoanaerobacter tengcongensis MB4, complete genomeFormyltetrahydrofolate synthetase0759
NC_018515:3600869:3617573361757336192431671Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeformyltetrahydrofolate synthetase0755
NC_015437:918614:9395609395609412271668Selenomonas sputigena ATCC 35185 chromosome, complete genomeFormate--tetrahydrofolate ligase0740
NC_015519:586000:5916105916105932891680Tepidanaerobacter sp. Re1 chromosome, complete genomeFormate--tetrahydrofolate ligase0721
NC_017179:805867:8151478151478168231677Clostridium difficile BI1, complete genomeformate--tetrahydrofolate ligase0721
NC_013315:796313:8055938055938072691677Clostridium difficile CD196 chromosome, complete genomeformate--tetrahydrofolate ligase0721
NC_013316:796895:8031338031338048091677Clostridium difficile R20291, complete genomeformate--tetrahydrofolate ligase0721
NC_009089:873295:8795458795458812211677Clostridium difficile 630, complete genomeformate--tetrahydrofolate ligase0721
NC_014654:2138794:2160274216027421619441671Halanaerobium sp. 'sapolanicus' chromosome, complete genomeFormate--tetrahydrofolate ligase0714
NC_014150:2399997:2415131241513124167921662Brachyspira murdochii DSM 12563 chromosome, complete genomeFormate--tetrahydrofolate ligase0711
NC_014614:1309203:1318853131885313205291677Clostridium sticklandii, complete genomeFormate-tetrahydrofolate ligase (Formyltetrahydrofolate synthetase) (FHS) (FTHFS)0711
NC_013192:519600:5357825357825374521671Leptotrichia buccalis DSM 1135, complete genomeFormate--tetrahydrofolate ligase0705
NC_014328:4073714:4088691408869140903671677Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeformate-tetrahydrofolate ligase0694
NC_007296:1762000:1770301177030117719741674Streptococcus pyogenes MGAS6180, complete genomeformate--tetrahydrofolate ligase0679
NC_014633:265086:2845252845252861891665Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceformate-tetrahydrofolate ligase0678
NC_015516:1222632:1243228124322812449011674Melissococcus plutonius ATCC 35311, complete genomeformate--tetrahydrofolate ligase0663
NC_015578:1038588:1038588103858810403211734Treponema primitia ZAS-2 chromosome, complete genomeformate--tetrahydrofolate ligase0655
NC_014217:2172464:2181300218130021829941695Starkeya novella DSM 506 chromosome, complete genomeFormate--tetrahydrofolate ligase1e-180633
NC_016801:1255611:1275055127505512767071653Corynebacterium diphtheriae C7 (beta) chromosome, complete genomeformate-tetrahydrofolate ligase2e-169595
NC_016782:1227246:1229995122999512316471653Corynebacterium diphtheriae 241 chromosome, complete genomeformate-tetrahydrofolate ligase7e-169594
NC_016786:1218032:1229964122996412316161653Corynebacterium diphtheriae HC01 chromosome, complete genomeformate-tetrahydrofolate ligase7e-169594
NC_016790:1177349:1196797119679711984491653Corynebacterium diphtheriae VA01 chromosome, complete genomeformate-tetrahydrofolate ligase7e-169594
NC_016787:1207488:1219420121942012210721653Corynebacterium diphtheriae HC03 chromosome, complete genomeformate-tetrahydrofolate ligase6e-169594
NC_016800:1243000:1258393125839312600451653Corynebacterium diphtheriae BH8 chromosome, complete genomeformate-tetrahydrofolate ligase5e-169594
NC_016785:1193471:1210042121004212116941653Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomeformate-tetrahydrofolate ligase8e-169593
NC_016788:1214026:1229407122940712310591653Corynebacterium diphtheriae HC04 chromosome, complete genomeformate-tetrahydrofolate ligase8e-169593
NC_016783:1239293:1255864125586412575161653Corynebacterium diphtheriae INCA 402 chromosome, complete genomeformate-tetrahydrofolate ligase8e-169593
NC_016799:1268706:1285277128527712869291653Corynebacterium diphtheriae 31A chromosome, complete genomeformate-tetrahydrofolate ligase2e-168592
NC_002935:1237585:1256231125623112578831653Corynebacterium diphtheriae NCTC 13129, complete genomeformyltetrahydrofolate synthetase2e-168592
NC_016802:1212726:1229297122929712309491653Corynebacterium diphtheriae HC02 chromosome, complete genomeformate-tetrahydrofolate ligase2e-168592
NC_016789:1257392:1273962127396212756141653Corynebacterium diphtheriae PW8 chromosome, complete genomeformate-tetrahydrofolate ligase7e-168590
NC_002689:78297:9032690326919361611Thermoplasma volcanium GSS1, complete genomeFormyltetrahydrofolate synthetase2e-150533
NC_008148:792610:8009878009878027171731Rubrobacter xylanophilus DSM 9941, complete genomeFormate--tetrahydrofolate ligase3e-148525
NC_008148:2498000:2532498253249825342191722Rubrobacter xylanophilus DSM 9941, complete genomeFormate--tetrahydrofolate ligase5e-148525
NC_008148:1567703:1590373159037315921031731Rubrobacter xylanophilus DSM 9941, complete genomeFormate--tetrahydrofolate ligase2e-147523
NC_015682:379373:3951503951503969311782Thermodesulfobacterium sp. OPB45 chromosome, complete genomeFormate--tetrahydrofolate ligase1e-123444