Pre_GI: BLASTP Hits

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Query: NC_008593:153014:159725 Clostridium novyi NT, complete genome

Start: 159725, End: 160111, Length: 387

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:163000:169753169753170148396Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein4e-65246
NC_004557:162670:166633166633167016384Clostridium tetani E88, complete genomedihydrolipoamide acyltransferase2e-30130
NC_015873:1241354:126193812619381262342405Megasphaera elsdenii DSM 20460, complete genomethioesterase family protein2e-27120
NC_009012:2661795:267993626799362680340405Clostridium thermocellum ATCC 27405, complete genomethioesterase family protein2e-26117
NC_015160:1961789:196178919617891962160372Odoribacter splanchnicus DSM 20712 chromosome, complete genomethioesterase superfamily protein8e-2095.9
NC_007296:1073784:107603910760391076404366Streptococcus pyogenes MGAS6180, complete genomehypothetical protein2e-1581.3
NC_014834:959986:987826987826988287462Rhodopseudomonas palustris DX-1 chromosome, complete genomehypothetical protein1e-1478.6
NC_011146:4505821:451925545192554519668414Geobacter bemidjiensis Bem, complete genomehypothetical protein3e-1477.4
NC_010623:72500:921129211292525414Burkholderia phymatum STM815 chromosome 2, complete sequencehypothetical protein1e-0858.9
NC_015388:1161740:116389811638981164314417Desulfobacca acetoxidans DSM 11109 chromosome, complete genomehypothetical protein3e-0753.9