Pre_GI: BLASTP Hits

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Query: NC_008593:153014:155546 Clostridium novyi NT, complete genome

Start: 155546, End: 156940, Length: 1395

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:163000:1656221656221670251404Clostridium botulinum BKT015925 chromosome, complete genomecell cycle protein MesJ0656
NC_014328:4471995:4497934449793444993401407Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative tRNA(Ile)-lysidine synthase4e-144511
NC_004557:162670:1626701626701640731404Clostridium tetani E88, complete genomecell cycle protein mesJ2e-127456
NC_008262:2649289:2693810269381026952191410Clostridium perfringens SM101, complete genometRNA(Ile)-lysidine synthetase6e-118424
NC_009698:3609881:3643059364305936444651407Clostridium botulinum A str. Hall chromosome, complete genometRNA(Ile)-lysidine synthetase1e-114413
NC_009495:3735703:3769960376996037713661407Clostridium botulinum A str. ATCC 3502 chromosome, complete genometRNA(Ile)-lysidine synthetase1e-114413
NC_009699:3839575:3872747387274738741531407Clostridium botulinum F str. Langeland chromosome, complete genometRNA(Ile)-lysidine synthetase2e-114412
NC_010723:173280:1812001812001826061407Clostridium botulinum E3 str. Alaska E43, complete genometRNA(Ile)-lysidine synthase4e-113408
NC_020291:117983:1330981330981345041407Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genometRNA(Ile)-lysidine synthase TilS8e-108390
NC_009012:2661795:2683143268314326845551413Clostridium thermocellum ATCC 27405, complete genometRNA(Ile)-lysidine synthetase1e-96353
NC_003869:2267627:2283780228378022851831404Thermoanaerobacter tengcongensis MB4, complete genomepredicted ATPase of the PP-loop superfamily implicated in cell cycle control1e-94347
NC_013316:4018451:4040068404006840414561389Clostridium difficile R20291, complete genomeputative ATPase3e-90332
NC_009089:4140764:4161747416174741631351389Clostridium difficile 630, complete genomeputative ATPase3e-90332
NC_018664:2459994:2484668248466824860501383Clostridium acidurici 9a chromosome, complete genometRNA(Ile)-lysidine synthase8e-89327
NC_015958:2361551:2377798237779823791741377Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genometRNA(Ile)-lysidine synthase9e-88324
NC_010320:819326:8235828235828249581377Thermoanaerobacter sp. X514 chromosome, complete genometRNA(Ile)-lysidine synthetase1e-87324
NC_015275:3680323:3680323368032336816961374Clostridium lentocellum DSM 5427 chromosome, complete genometRNA(Ile)-lysidine synthetase5e-63242
NC_017208:64500:6731767317686091293Bacillus thuringiensis serovar chinensis CT-43 chromosome, completecell cycle protein MesJ6e-48192
NC_018704:81733:8173381733831361404Amphibacillus xylanus NBRC 15112, complete genometRNA(Ile)-lysidine synthase1e-47190
NC_011565:1:5397539767401344Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,tRNA(Ile)-lysidine synthase1e-45184
NC_016641:1639356:1657391165739116588391449Paenibacillus terrae HPL-003 chromosome, complete genometRNA(Ile)-lysidine synthase2e-43177
NC_014483:39729:5869858698601461449Paenibacillus polymyxa E681 chromosome, complete genometRNA(Ile)-lysidine synthase2e-43176
NC_007498:1148249:1168260116826011696361377Pelobacter carbinolicus DSM 2380, complete genomecell cycle protein6e-43175
NC_015318:1455444:145731014573101458278969Hippea maritima DSM 10411 chromosome, complete genometRNA(Ile)-lysidine synthase2e-41170
NC_015703:4933430:4986515498651549878341320Runella slithyformis DSM 19594 chromosome, complete genometRNA(Ile)-lysidine synthase3e-41169
NC_015978:412856:4141134141134154981386Lactobacillus sanfranciscensis TMW 1.1304 chromosome, completehypothetical protein2e-35150
NC_013037:6281164:6286374628637462877081335Dyadobacter fermentans DSM 18053, complete genometRNA(Ile)-lysidine synthetase3e-35150
NC_014758:1489761:1510126151012615113881263Calditerrivibrio nitroreducens DSM 19672 chromosome, completetRNA(ile)-lysidine synthetase8e-35148
NC_013939:1023443:1026346102634610276051260Deferribacter desulfuricans SSM1, complete genomecell cycle protein MesJ1e-33144
NC_020054:4795000:4814976481497648163371362Fibrella aestuarina BUZ 2 drat genometRNA(Ile)-lysidine synthase1e-33144
NC_007576:1564739:1584015158401515854091395Lactobacillus sakei subsp. sakei 23K, complete genomePutative ATPase of the PP-loop superfamily, cell cycle protein2e-31137
NC_008710:819389:8323068323068336251320Borrelia turicatae 91E135, complete genometRNA(Ile)-lysidine synthetase TilS1e-30134
NC_017316:203233:2048042048042062971494Enterococcus faecalis OG1RF chromosome, complete genometRNA(Ile)-lysidine synthase2e-29130
NC_019960:801589:8015898015898029321344Prevotella dentalis DSM 3688 chromosome 1, complete sequencetRNA(Ile)-lysidine synthetase1e-28127
NC_014150:2055907:2077601207760120789531353Brachyspira murdochii DSM 12563 chromosome, complete genometRNA(Ile)-lysidine synthetase2e-28127
NC_015760:8914:1070510705119701266Streptococcus salivarius CCHSS3, complete genometRNA(Ile)-lysidine synthase1e-27125
NC_008497:556365:5563655563655577171353Lactobacillus brevis ATCC 367, complete genometRNA(Ile)-lysidine synthetase, MesJ2e-26120
NC_004757:1089057:1109547110954711109231377Nitrosomonas europaea ATCC 19718, complete genomehypothetical protein2e-26120
NC_016605:272231:2738212738212751731353Pediococcus claussenii ATCC BAA-344 chromosome, complete genometRNA(Ile)-lysidine synthetase4e-26119
NC_006448:5046:1078810788120531266Streptococcus thermophilus LMG 18311, complete genomeputative cell-cycle protein, MesJ/Ycf62 family4e-25116
NC_006449:5046:1078810788120531266Streptococcus thermophilus CNRZ1066, complete genomeputative cell-cycle protein, MesJ/Ycf62 family4e-25116
NC_009513:303043:3030433030433044371395Lactobacillus reuteri F275, complete genometRNA(Ile)-lysidine synthetase6e-25115
NC_007929:1397989:1418710141871014200681359Lactobacillus salivarius subsp. salivarius UCC118, complete genometRNA(Ile)-lysidine synthase TilS1e-23111
NC_012121:139741:1624001624001636801281Staphylococcus carnosus subsp. carnosus TM300, complete genomeputative PP-loop family protein2e-23110
NC_008525:1493317:1514730151473015161001371Pediococcus pentosaceus ATCC 25745, complete genometRNA(Ile)-lysidine synthetase, MesJ3e-23110
NC_014109:326500:3411323411323424961365Candidatus Riesia pediculicola USDA chromosome, complete genometRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase)4e-22106
NC_013928:9494:1085510855121261272Streptococcus mutans NN2025, complete genomecell-cycle protein9e-22105
NC_007604:1145373:1161580116158011625901011Synechococcus elongatus PCC 7942, complete genomeconserved hypothetical protein YCF627e-22105
NC_007347:1215358:1217181121718112186351455Ralstonia eutropha JMP134 chromosome 1, complete sequencePP-loop6e-22105
NC_015930:18969:1896918969202221254Lactococcus garvieae ATCC 49156, complete genomehypothetical protein2e-21104
NC_014761:1196669:1212383121238312139511569Oceanithermus profundus DSM 14977 chromosome, complete genometRNA(ile)-lysidine synthetase9e-2098.6
NC_017285:913000:930916930916931875960Chlamydophila pneumoniae LPCoLN chromosome, complete genometRNA(Ile)-lysidine synthetase4e-1893.2
NC_016745:2785346:2812901281290128142321332Oceanimonas sp. GK1 chromosome, complete genometRNA(Ile)-lysidine synthetase4e-1789.7
NC_006085:308567:311745311745312680936Propionibacterium acnes KPA171202, complete genomehypothetical protein2e-1687.8
NC_016511:308244:311422311422312357936Propionibacterium acnes TypeIA2 P.acn31 chromosome, completehypothetical protein2e-1687.8
NC_016512:305240:310786310786311721936Propionibacterium acnes TypeIA2 P.acn17 chromosome, completehypothetical protein2e-1687.8
NC_016516:300846:302219302219303154936Propionibacterium acnes TypeIA2 P.acn33 chromosome, completehypothetical protein2e-1687.8
NC_014039:334892:338052338052339005954Propionibacterium acnes SK137 chromosome, complete genometRNA(Ile)-lysidine synthetase2e-1687.8
NC_006576:456569:458214458214459065852Synechococcus elongatus PCC 6301, complete genomehypothetical protein YCF625e-1686.3
NC_012880:3421500:3451366345136634527121347Dickeya dadantii Ech703, complete genometRNA(Ile)-lysidine synthetase1e-1585.1
NC_004547:1174650:1174650117465011759721323Erwinia carotovora subsp. atroseptica SCRI1043, complete genomecell cycle protein8e-1582
NC_016513:1400899:1402383140238314037291347Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completeDNA mismatch repair protein2e-1481.3
NC_013416:1091432:1094201109420110955471347Aggregatibacter actinomycetemcomitans D11S-1, complete genometRNA(Ile)-lysidine synthase2e-1480.9
NC_006055:769418:7837767837767849721197Mesoplasma florum L1, complete genomelysidine synthetase4e-1480.1
NC_007954:1823085:1826662182666218280921431Shewanella denitrificans OS217, complete genometRNA(Ile)-lysidine synthetase-like protein3e-1480.1
NC_011999:2023248:2039599203959920408101212Macrococcus caseolyticus JCSC5402, complete genomehypothetical protein2e-1377.8
NC_020211:4168189:4189337418933741906681332Serratia marcescens WW4, complete genometRNA(Ile)-lysidine synthetase2e-1377.4
NC_015725:926824:944242944242945102861Mycoplasma bovis Hubei-1 chromosome, complete genomehypothetical protein1e-1274.7
NC_007940:1485006:1492614149261414939061293Rickettsia bellii RML369-C, complete genometRNA(Ile)-lysidine synthetase2e-1274.3
NC_009883:1492425:1500037150003715013291293Rickettsia bellii OSU 85-389, complete genometRNA(Ile)-lysidine synthetase2e-1274.3
NC_008787:1345988:136834513683451369310966Campylobacter jejuni subsp. jejuni 81-176, complete genometRNA(Ile)-lysidine synthetase3e-1273.9
NC_018868:282738:299473299473300393921Simiduia agarivorans SA1 = DSM 21679 chromosome, complete genomehypothetical protein2e-1067.8
NC_008599:1489868:149288114928811493633753Campylobacter fetus subsp. fetus 82-40, complete genomePP-loop family protein2e-1067.4
NC_014153:436082:4554634554634565151053Thiomonas intermedia K12 chromosome, complete genometRNA(Ile)-lysidine synthetase2e-1067.4
NC_014935:1999653:2030660203066020316941035Nitratifractor saLSUginis DSM 16511 chromosome, complete genometRNA(ile)-lysidine synthetase2e-1067.4
NC_007951:4608560:4627865462786546288751011Burkholderia xenovorans LB400 chromosome 1, complete sequencehypothetical protein2e-1067.4
NC_014205:760428:763414763414764409996Staphylothermus hellenicus DSM 12710 chromosome, complete genomePP-loop domain protein3e-1067
NC_015381:4182194:418259541825954183584990Burkholderia gladioli BSR3 chromosome 1, complete sequencePP-loop family protein3e-1067
NC_004545:96422:1153061153061166221317Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genomeputative cell cycle protein MesJ9e-1065.5
NC_016589:2875000:2903444290344429044511008Burkholderia sp. YI23 chromosome 1, complete sequencePP-loop domain-containing protein2e-0963.9
NC_005861:1027000:104063410406341041374741Candidatus Protochlamydia amoebophila UWE25, complete genomehypothetical protein5e-0962.8
NC_011415:1472500:147444114744411475376936Escherichia coli SE11 chromosome, complete genomeC32 tRNA thiolase1e-0862
NC_012947:2366000:238526623852662386201936Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeC32 tRNA thiolase1e-0862
NC_012967:1403733:140818314081831409118936Escherichia coli B str. REL606 chromosome, complete genomeC32 tRNA thiolase1e-0862
CP002516:2580774:260536326053632606298936Escherichia coli KO11, complete genomePP-loop domain protein9e-0962
CP002185:1493280:149955214995521500487936Escherichia coli W, complete genomepredicted C32 tRNA thiolase9e-0962
NC_016902:2580774:260536326053632606298936Escherichia coli KO11FL chromosome, complete genomePP-loop domain-containing protein9e-0962
NC_009515:510121:531360531360532277918Methanobrevibacter smithii ATCC 35061, complete genomePP family ATPase9e-0962
NC_012759:1296000:130109613010961302031936Escherichia coli BW2952 chromosome, complete genomeC32 tRNA thiolase1e-0861.6
AC_000091:1407693:141272714127271413662936Escherichia coli W3110 DNA, complete genomepredicted C32 tRNA thiolase1e-0861.6
NC_000913:1404000:140903714090371409972936Escherichia coli K12, complete genomepredicted C32 tRNA thiolase1e-0861.6
NC_010473:1493983:149843314984331499368936Escherichia coli str. K-12 substr. DH10B, complete genomeputative tRNA 2-thiocytidine (s(2)C32) synthase1e-0861.6
NC_009648:1541699:154169915416991542634936Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeC32 tRNA thiolase3e-0860.5
NC_020063:2449554:246555224655522466487936Enterobacteriaceae bacterium strain FGI 57, complete genomeputative ATPase of the PP-loop superfamily implicated in cell cycle control3e-0860.1
NC_008463:4342119:434425743442574345081825Pseudomonas aeruginosa UCBPP-PA14, complete genomeputative ATPase of the PP-loop superfamily3e-0860.1
NC_011770:4542183:454432145443214545145825Pseudomonas aeruginosa LESB58, complete genomeputative ATPase of the PP-loop superfamily3e-0860.1
NC_008942:960306:963510963510964412903Methanocorpusculum labreanum Z, complete genomehypothetical protein5e-0859.7
NC_013716:1756545:176912717691271770062936Citrobacter rodentium ICC168, complete genometRNA 2-thiocytidine biosynthesis protein ttcA5e-0859.3
NC_014151:657382:6714666714666726261161Cellulomonas flavigena DSM 20109 chromosome, complete genometRNA(Ile)-lysidine synthetase7e-0858.9
NC_011294:1465500:146842814684281469363936Salmonella enterica subsp. enterica serovar Enteritidis strC32 tRNA thiolase7e-0858.9
NC_011149:1429523:145488714548871455822936Salmonella enterica subsp. enterica serovar Agona str. SL483,YdaO7e-0858.9
NC_015761:1630000:163960516396051640540936Salmonella bongori NCTC 12419, complete genomehypothetical protein9e-0858.9
NC_008825:564392:586478586478587419942Methylibium petroleiphilum PM1, complete genomehypothetical protein1e-0758.5
NC_014315:1668366:168172916817291682613885Nitrosococcus watsoni C-113 chromosome, complete genomePP-loop domain-containing protein1e-0758.5
NC_012917:2641000:265690226569022657837936Pectobacterium carotovorum subsp. carotovorum PC1, complete genomePP-loop domain protein1e-0758.2
NC_011529:1554500:155663715566371557608972Thermococcus onnurineus NA1, complete genomeATPase2e-0757.4
NC_008800:2298000:230832423083242309265942Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,C32 tRNA thiolase2e-0757.4
NC_014121:1848971:185572818557281856663936Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completeC32 tRNA thiolase3e-0757
NC_010520:3580000:358509335850933585842750Clostridium botulinum A3 str. Loch Maree, complete genomePP-loop family protein4e-0756.6
NC_016051:1429800:145592514559251456902978Thermococcus sp. AM4 chromosome, complete genomePP-loop superfamily ATPase5e-0756.2
NC_009495:3502000:350722135072213507970750Clostridium botulinum A str. ATCC 3502 chromosome, complete genomePP-loop family protein9e-0755.5
NC_009697:3463736:348320934832093483958750Clostridium botulinum A str. ATCC 19397 chromosome, completePP-loop family protein9e-0755.5
NC_009698:3359766:338031733803173381066750Clostridium botulinum A str. Hall chromosome, complete genomePP-loop family protein9e-0755.5
NC_014374:344500:349736349736350725990Acidilobus saccharovorans 345-15 chromosome, complete genomehypothetical protein1e-0655.1
NC_015931:1653604:1653604165360416546471044Pyrolobus fumarii 1A, complete genomePP-loop domain containing protein1e-0655.1
NC_012563:3729817:374929537492953750044750Clostridium botulinum A2 str. Kyoto, complete genomePP-loop family protein1e-0654.7
NC_009975:1203372:122850712285071229481975Methanococcus maripaludis C6, complete genomePP-loop domain protein1e-0654.7
NC_015958:1465631:147908314790831479790708Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomePP-loop domain-containing protein2e-0654.7
NC_005213:202400:255499255499256305807Nanoarchaeum equitans Kin4-M, complete genomehypothetical protein2e-0654.3
NC_009699:3581376:360085536008553601604750Clostridium botulinum F str. Langeland chromosome, complete genomePP-loop family protein2e-0653.9
NC_017297:3594000:359947135994713600220750Clostridium botulinum F str. 230613 chromosome, complete genomePP-loop family protein2e-0653.9
NC_015562:1816000:183104018310401831951912Methanotorris igneus Kol 5 chromosome, complete genometRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase5e-0652.8
NC_009092:2282437:230676723067672307720954Shewanella loihica PV-4, complete genomePP-loop domain protein5e-0652.8
NC_010321:1361748:137499913749991375706708Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completePP-loop domain-containing protein6e-0652.4
NC_014964:1353939:136718913671891367896708Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completePP-loop domain-containing protein6e-0652.4
NC_009635:800000:8249398249398259431005Methanococcus aeolicus Nankai-3 chromosome, complete genomePP-loop domain-containing protein9e-0652