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Query: NC_008593:153014:153014 Clostridium novyi NT, complete genome

Start: 153014, End: 155410, Length: 2397

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:163000:1637911637911655211731Clostridium botulinum BKT015925 chromosome, complete genomestage II sporulation protein E0992
NC_014328:4471995:4499768449976845021552388Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative stage II sporulation protein E0793
NC_009699:3839575:3874302387430238766892388Clostridium botulinum F str. Langeland chromosome, complete genomestage II sporulation protein E0790
NC_008262:2649289:2695434269543426978242391Clostridium perfringens SM101, complete genomestage II sprulation protein E, putative3e-170599
NC_010723:173280:1786801786801810612382Clostridium botulinum E3 str. Alaska E43, complete genomestage II sporulation protein E4e-152539
NC_020291:117983:1305001305001328962397Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomestage II sporulation protein E3e-137489
NC_009922:2850320:2854406285440628568112406Alkaliphilus oremlandii OhILAs, complete genomestage II sporulation protein E, protein serine/threonine phosphatase3e-95350
NC_009633:168266:1890701890701914722403Alkaliphilus metalliredigens QYMF chromosome, complete genomesporulation stage II, protein E2e-86320
NC_015958:2361551:2379930237993023822752346Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomestage II sporulation protein E, protein serine/threonine phosphatase3e-85317
NC_010320:819326:8210768210768234212346Thermoanaerobacter sp. X514 chromosome, complete genomephosphoprotein phosphatase9e-79295
NC_014483:39729:5432654326568332508Paenibacillus polymyxa E681 chromosome, complete genomeStage II sporulation protein E2e-66254
NC_016641:1639356:1653016165301616555232508Paenibacillus terrae HPL-003 chromosome, complete genomestage II sporulation protein e, protein serine/threonine phosphatase3e-66253
NC_017208:64500:6461564615670862472Bacillus thuringiensis serovar chinensis CT-43 chromosome, completestage II sporulation protein E1e-53211