Pre_GI: BLASTP Hits

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Query: NC_008593:1461771:1476824 Clostridium novyi NT, complete genome

Start: 1476824, End: 1477258, Length: 435

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:1950205:195474719547471955208462Clostridium perfringens SM101, complete genomeuncharacterized conserved protein of YjeB/RRF2 family6e-58222
NC_009699:2733529:275432327543232754769447Clostridium botulinum F str. Langeland chromosome, complete genomerrF2 family protein3e-57219
NC_009495:2685646:270636227063622706808447Clostridium botulinum A str. ATCC 3502 chromosome, complete genometranscriptional regulator3e-57219
NC_021182:2422226:243676224367622437202441Clostridium pasteurianum BC1, complete genomerrf2 family protein, putative transcriptional regulator2e-53206
NC_017295:1809386:182411718241171824536420Clostridium acetobutylicum EA 2018 chromosome, complete genometranscriptional regulator (HTH winged helix type)3e-53206
NC_015687:1811573:182630418263041826723420Clostridium acetobutylicum DSM 1731 chromosome, complete genometranscriptional regulator3e-53206
NC_003030:1811820:182470418247041825123420Clostridium acetobutylicum ATCC 824, complete genomePredicted transcriptional regulator (HTH winged helix type)3e-53206
NC_014328:1307490:130946913094691309915447Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative transcriptional regulator1e-51201
NC_003366:2057656:206543720654372065823387Clostridium perfringens str. 13, complete genomehypothetical protein7e-44175
NC_014377:1089894:110347411034741103926453Thermosediminibacter oceani DSM 16646 chromosome, complete genometranscriptional regulator, BadM/Rrf2 family3e-42170
NC_016012:805680:810599810599811045447Candidatus Arthromitus sp. SFB-rat-Yit, complete genomeRRF2 family protein4e-42169
NC_012034:1783912:180473918047391805191453Anaerocellum thermophilum DSM 6725, complete genometranscriptional regulator, BadM/Rrf2 family1e-39161
NC_018515:989616:995290995290995742453Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeRrf2 family transcriptional regulator2e-39160
NC_014652:1032711:105395410539541054406453Caldicellulosiruptor hydrothermalis 108 chromosome, completetranscriptional regulator, badm/rrf2 family2e-39160
NC_014657:1518721:153989615398961540348453Caldicellulosiruptor owensensis OL chromosome, complete genometranscriptional regulator, badm/rrf2 family2e-39160
NC_014721:1777644:179835917983591798811453Caldicellulosiruptor kristjanssonii 177R1B chromosome, completetranscriptional regulator, badm/rrf2 family6e-39159
NC_015949:1180755:120145512014551201907453Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomeBadM/Rrf2 family transcriptional regulator6e-39159
NC_009437:2367842:238853223885322388984453Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeBadM/Rrf2 family transcriptional regulator4e-39159
NC_014392:969498:989139989139989591453Caldicellulosiruptor obsidiansis OB47 chromosome, complete genometranscriptional regulator, BadM/Rrf2 family9e-39158
NC_019978:1816940:183458218345821835040459Halobacteroides halobius DSM 5150, complete genomerrf2 family protein, putative transcriptional regulator1e-37155
NC_011830:3786173:380502638050263805466441Desulfitobacterium hafniense DCB-2, complete genometranscriptional regulator, BadM/Rrf2 family3e-35147
NC_009012:2953638:299313429931342993577444Clostridium thermocellum ATCC 27405, complete genometranscriptional regulator, BadM/Rrf2 family2e-34144
NC_011899:948790:955560955560956015456Halothermothrix orenii H 168, complete genometranscriptional regulator, BadM/Rrf2 family4e-34143
NC_010718:304440:319008319008319475468Natranaerobius thermophilus JW/NM-WN-LF, complete genometranscriptional regulator, BadM/Rrf2 family2e-33140
NC_011725:4373721:437490243749024375318417Bacillus cereus B4264 chromosome, complete genomerrf2 family protein5e-32136
NC_016627:3158353:317550531755053175954450Clostridium clariflavum DSM 19732 chromosome, complete genomerrf2 family protein, putative transcriptional regulator5e-32135
NC_013740:2141523:215595221559522156374423Acidaminococcus fermentans DSM 20731, complete genometranscriptional regulator, BadM/Rrf2 family6e-31132
NC_016627:2524307:253149425314942531952459Clostridium clariflavum DSM 19732 chromosome, complete genomerrf2 family protein, putative transcriptional regulator1e-30131
NC_016627:2524307:253095125309512531400450Clostridium clariflavum DSM 19732 chromosome, complete genomerrf2 family protein, putative transcriptional regulator7e-30129
NC_010001:1:114341143411871438Clostridium phytofermentans ISDg, complete genometranscriptional regulator, BadM/Rrf2 family4e-28123
NC_015437:918614:933404933404933835432Selenomonas sputigena ATCC 35185 chromosome, complete genometranscriptional regulator, BadM/Rrf2 family2e-26117
NC_012559:2752825:277138227713822771861480Laribacter hongkongensis HLHK9, complete genomePredicted transcriptional regulator3e-26117
NC_002946:618439:625195625195625641447Neisseria gonorrhoeae FA 1090, complete genomehypothetical protein2e-25114
NC_011035:1033942:104694410469441047390447Neisseria gonorrhoeae NCCP11945 chromosome, complete genomePutative HTH-type transcriptional regulator NMB13782e-25114
NC_017511:950411:962769962769963215447Neisseria gonorrhoeae TCDC-NG08107 chromosome, complete genomehypothetical protein2e-25114
NC_008576:3812500:383085538308553831328474Magnetococcus sp. MC-1, complete genometranscriptional regulator, BadM/Rrf2 family9e-25112
NC_007484:1823751:184336618433661843866501Nitrosococcus oceani ATCC 19707, complete genomeIron-sulphur cluster assembly transcription factor IscR3e-24110
NC_015731:2148517:217108821710882171549462Nitrosomonas sp. Is79A3 chromosome, complete genomeBadM/Rrf2 family transcriptional regulator3e-24110
NC_011297:1357947:137869413786941379128435Dictyoglomus thermophilum H-6-12, complete genomeRRF2 protein family6e-24109
NC_008260:2142311:214851621485162148980465Alcanivorax borkumensis SK2, complete genomerrf2 family protein9e-24108
NC_015856:3675592:367686336768633677357495Collimonas fungivorans Ter331 chromosome, complete genomeIron-sulfur cluster regulator IscR1e-23108
NC_014844:2158318:215831821583182158755438Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomeRrf2 family transcriptional regulator3e-21100
NC_017517:1377617:139072013907201391166447Neisseria meningitidis M01-240355 chromosome, complete genomeiron-sulfur cluster assembly transcription factor IscR5e-2199.8
NC_017516:917817:924802924802925248447Neisseria meningitidis H44/76 chromosome, complete genomeiron-sulfur cluster assembly transcription factor IscR5e-2199.8
NC_017512:1264542:127686512768651277311447Neisseria meningitidis WUE 2594, complete genomeiron-sulfur cluster-assembly HTH-type transcriptional repressor IscR5e-2199.8
NC_017505:1338661:135301813530181353464447Neisseria meningitidis alpha710 chromosome, complete genomeDNA-binding protein5e-2199.8
NC_013016:1257942:127286812728681273314447Neisseria meningitidis alpha14 chromosome, complete genomeputative transcription factor5e-2199.8
NC_003116:1488576:150089915008991501345447Neisseria meningitidis Z2491, complete genomehypothetical protein5e-2199.8
NC_014221:1932903:193711319371131937562450Truepera radiovictrix DSM 17093 chromosome, complete genometranscriptional regulator, BadM/Rrf2 family5e-2199.8
NC_007109:894000:895210895210895629420Rickettsia felis URRWXCal2, complete genomeIron-sulfur cluster assembly transcription factor IscR4e-2096.7
NC_015389:1298689:132255113225511323003453Coriobacterium glomerans PW2 chromosome, complete genometranscriptional regulator, BadM/Rrf2 family2e-1994.4
NC_016830:1182765:121262212126221213074453Pseudomonas fluorescens F113 chromosome, complete genomeprotein IscR2e-1890.5
NC_017187:2037988:204214020421402042553414Arcobacter butzleri ED-1, complete genomeBadM/Rrf2 family transcriptional regulator4e-1890.1
NC_009952:1680682:169719516971951697683489Dinoroseobacter shibae DFL 12, complete genomeHTH-type transcriptional regulator2e-1787.8
NC_008343:1470360:147781114778111478350540Granulibacter bethesdensis CGDNIH1, complete genomerrf2 family protein1e-1685.1
NC_009925:3344894:334825333482533348696444Acaryochloris marina MBIC11017, complete genometranscriptional Regulator, BadM/Rrf2 family2e-1684
NC_006576:2610565:261621826162182616673456Synechococcus elongatus PCC 6301, complete genomehypothetical protein2e-1581.3
NC_007604:1512709:151899415189941519449456Synechococcus elongatus PCC 7942, complete genomehypothetical protein2e-1581.3
NC_008726:4725389:474162347416234742099477Mycobacterium vanbaalenii PYR-1, complete genometranscriptional regulator, BadM/Rrf2 family2e-1581.3
NC_011979:2892119:289631228963122896725414Geobacter sp. FRC-32, complete genometranscriptional regulator, BadM/Rrf2 family4e-1580.1
NC_017098:1542284:154845215484521548958507Spirochaeta africana DSM 8902 chromosome, complete genomeRrf2 family transcriptional regulator7e-1579.3
NC_011145:1435742:143574214357421436224483Anaeromyxobacter sp. K, complete genometranscriptional regulator, BadM/Rrf2 family7e-1579.3
NC_007760:2897409:291531029153102915789480Anaeromyxobacter dehalogenans 2CP-C, complete genometranscriptional regulator, BadM/Rrf2 family1e-1478.6
NC_009483:2489000:252245825224582522871414Geobacter uraniireducens Rf4 chromosome, complete genomeBadM/Rrf2 family transcriptional regulator1e-1478.2
NC_015434:1885373:188706118870611887516456Verrucosispora maris AB-18-032 chromosome, complete genomeBadM/Rrf2 family transcriptional regulator2e-1477.4
NC_014221:1167261:117247511724751172915441Truepera radiovictrix DSM 17093 chromosome, complete genometranscriptional regulator, BadM/Rrf2 family3e-1477
NC_010337:803748:803748803748804233486Heliobacterium modesticaldum Ice1, complete genometranscriptional regulator, rrf2 family, putative4e-1477
NC_014391:1812500:181388418138841814339456Micromonospora aurantiaca ATCC 27029 chromosome, complete genomeRrf2 family transcriptional regulator4e-1476.6
NC_014815:2055286:205851120585112058966456Micromonospora sp. L5 chromosome, complete genometranscriptional regulator, badm/rrf2 family4e-1476.6
NC_010338:4015928:403720440372044037644441Caulobacter sp. K31, complete genometranscriptional regulator, BadM/Rrf2 family6e-1476.3
NC_005125:839000:849831849831850253423Gloeobacter violaceus PCC 7421, complete genomehypothetical protein9e-1475.5
NC_013960:2166367:217137921713792171789411Nitrosococcus halophilus Nc4 chromosome, complete genometranscriptional regulator, Rrf2 family1e-1375.1
NC_002696:2829002:284256528425652842996432Caulobacter crescentus CB15, complete genomeRrF2 family protein2e-1374.3
NC_013385:1882549:190942419094241909837414Ammonifex degensii KC4, complete genometranscriptional regulator, BadM/Rrf2 family3e-1373.9
NC_010104:1096081:111084711108471111347501Brucella canis ATCC 23365 chromosome II, complete sequencerrf2 family protein1e-1272
NC_010167:1287000:130504513050451305545501Brucella suis ATCC 23445 chromosome II, complete sequenceTranscriptional regulator, Rrf2 family protein1e-1272
NC_014100:1144463:115118811511881151619432Caulobacter segnis ATCC 21756 chromosome, complete genomeBadM/Rrf2 family transcriptional regulator1e-1272
NC_015589:626321:641545641545641970426Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeRrf2 family transcriptional regulator1e-1272
NC_003318:183914:187471187471187959489Brucella melitensis 16M chromosome II, complete sequenceRRF2 FAMILY PROTEIN1e-1271.6
NC_010740:1051000:106578510657851066285501Brucella abortus S19 chromosome 2, complete sequenceRRF2 family protein1e-1271.6
NC_006933:1051873:106659710665971067028432Brucella abortus biovar 1 str. 9-941 chromosome II, completeRfF2 family protein2e-1271.2
NC_009428:807577:810129810129810698570Rhodobacter sphaeroides ATCC 17025 chromosome, complete genomeBadM/Rrf2 family transcriptional regulator7e-1269.3
NC_015634:959396:984111984111984545435Bacillus coagulans 2-6 chromosome, complete genomeBadM/Rrf2 family transcriptional regulator3e-1167
NC_019892:3366463:338734333873433387804462Singulisphaera acidiphila DSM 18658 chromosome, complete genomeRrf2 family transcriptional regulator4e-1167
NC_008571:365047:372300372300372713414Gramella forsetii KT0803, complete genomeRrf2-like transcriptional regulator protein4e-1166.6
NC_020272:20435:261892618926692504Bacillus amyloliquefaciens IT-45, complete genomeHTH-type transcriptional regulator iscR6e-1166.2
NC_017188:461177:478328478328478831504Bacillus amyloliquefaciens TA208 chromosome, complete genometranscriptional regulator7e-1165.9
NC_013891:575746:587430587430587846417Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomeRrf2 family transcriptional regulator protein1e-1065.1
NC_014551:483773:490676490676491179504Bacillus amyloliquefaciens DSM 7, complete genometranscriptional regulator1e-1065.1
NC_015589:2480365:248474324847432485153411Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeRrf2 family transcriptional regulator2e-1064.3
NC_007940:669143:672492672492672902411Rickettsia bellii RML369-C, complete genomePutative transcriptional regulator3e-1063.9
NC_009883:641491:644840644840645289450Rickettsia bellii OSU 85-389, complete genomePutative transcriptional regulator3e-1063.9
NC_007705:1388607:141460314146031415061459Xanthomonas oryzae pv. oryzae MAFF 311018, complete genomehypothetical protein4e-1063.2
NC_006834:1414113:144025714402571440715459Xanthomonas oryzae pv. oryzae KACC10331, complete genomehypothetical protein5e-1063.2
NC_009848:720510:742990742990743427438Bacillus pumilus SAFR-032, complete genometranscriptional regulator6e-1062.8
NC_014377:321949:335662335662336069408Thermosediminibacter oceani DSM 16646 chromosome, complete genometranscriptional regulator, BadM/Rrf2 family1e-0962
NC_013520:571647:586930586930587361432Veillonella parvula DSM 2008, complete genometranscriptional regulator, BadM/Rrf2 family1e-0962
NC_014963:113015:135717135717136211495Terriglobus saanensis SP1PR4 chromosome, complete genomeBadM/Rrf2 family transcriptional regulator1e-0962
NC_010520:3674883:369132836913283691729402Clostridium botulinum A3 str. Loch Maree, complete genomeputative transcriptional regulator2e-0961.2
NC_009668:1591290:160547816054781605909432Ochrobactrum anthropi ATCC 49188 chromosome 2, complete sequenceBadM/Rrf2 family transcriptional regulator2e-0961.2
NC_010501:2609567:263382326338232634362540Pseudomonas putida W619, complete genometranscriptional regulator, BadM/Rrf2 family2e-0961.2
NC_015259:1512563:151741015174101517838429Polymorphum gilvum SL003B-26A1 chromosome, complete genomePutative HTH-type transcriptional regulator rrf2-like protein3e-0960.5
NC_006510:1731939:176516917651691765612444Geobacillus kaustophilus HTA426, complete genomehypothetical protein4e-0960.1
NC_007907:5104476:510869651086965109076381Desulfitobacterium hafniense Y51, complete genomehypothetical protein5e-0959.7
NC_012658:3678000:368338836833883683789402Clostridium botulinum Ba4 str. 657 chromosome, complete genomeRRF2 family protein7e-0959.3
NC_013766:679906:679906679906680322417Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein7e-0959.3
NC_012108:442493:459809459809460297489Desulfobacterium autotrophicum HRM2, complete genomehypothetical protein9e-0958.9
NC_011146:3537546:354820635482063548694489Geobacter bemidjiensis Bem, complete genometranscriptional regulator, BadM/Rrf2 family1e-0858.5
NC_008599:903530:924746924746925123378Campylobacter fetus subsp. fetus 82-40, complete genometranscriptional regulator, BadM/Rrf2 family2e-0857.4
NC_004311:1096649:111152111115211111916396Brucella suis 1330 chromosome II, complete sequenceRrF2 family protein3e-0857.4
NC_014364:2246524:228335622833562283736381Spirochaeta smaragdinae DSM 11293 chromosome, complete genometranscriptional regulator, BadM/Rrf2 family3e-0857
NC_016628:1:108901089011408519Vibrio furnissii NCTC 11218 chromosome 2, complete sequenceAsnC family transcriptional regulator4e-0856.6
NC_007624:1046500:106138910613891061784396Brucella melitensis biovar Abortus 2308 chromosome II, completehypothetical protein4e-0856.6
NC_013118:1109610:112446011244601124855396Brucella microti CCM 4915 chromosome 2, complete genometranscriptional regulator, RrF2 family4e-0856.6
NC_015858:1150446:116507411650741165469396Brucella pinnipedialis B2/94 chromosome chromosome 2, completetranscriptional regulator, Rrf2 family protein4e-0856.6
NC_008536:4921224:493025849302584930734477Solibacter usitatus Ellin6076, complete genometranscriptional regulator, BadM/Rrf2 family1e-0755.1
NC_016050:771752:783334783334783762429Rickettsia japonica YH, complete genomeputative transcriptional regulator2e-0754.7
NC_009254:745706:749444749444749956513Burkholderia vietnamiensis G4 chromosome 3, complete sequenceBadM/Rrf2 family transcriptional regulator2e-0754.7
NC_015866:767790:779257779257779685429Rickettsia heilongjiangensis 054 chromosome, complete genomePutative transcriptional regulator2e-0754.7
NC_011206:2685499:272482727248272725267441Acidithiobacillus ferrooxidans ATCC 53993, complete genometranscriptional regulator, BadM/Rrf2 family1e-0652
NC_011761:2785660:282498828249882825428441Acidithiobacillus ferrooxidans ATCC 23270 chromosome, completeRrf2 family protein1e-0652
NC_008209:761487:763317763317763787471Roseobacter denitrificans OCh 114, complete genomehypothetical protein1e-0652
NC_008825:3161146:316408931640893164643555Methylibium petroleiphilum PM1, complete genomeputative transcriptional regulator PA26921e-0652
NC_016642:1990684:199633319963331996725393Pseudovibrio sp. FO-BEG1 chromosome, complete genometranscriptional regulator, Rrf22e-0651.2
NC_020064:3998715:408478040847804085310531Serratia marcescens FGI94, complete genomerrf2 family protein, putative transcriptional regulator3e-0650.8
NC_007797:692944:6940786940786955381461Anaplasma phagocytophilum HZ, complete genomerrf2 family protein /cysteine desulfurase5e-0649.7
NC_016612:3803130:381278938127893813133345Klebsiella oxytoca KCTC 1686 chromosome, complete genomeputative transcriptional regulator6e-0649.7
NC_013730:2187898:220344222034422203903462Spirosoma linguale DSM 74, complete genometranscriptional regulator, BadM/Rrf2 family6e-0649.7