Pre_GI: BLASTP Hits

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Query: NC_008593:1461771:1470751 Clostridium novyi NT, complete genome

Start: 1470751, End: 1471005, Length: 255

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017295:1809386:182917218291721829432261Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein3e-34143
NC_015687:1811573:183135918313591831619261Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein3e-34143
NC_003030:1811820:182975918297591830019261Clostridium acetobutylicum ATCC 824, complete genomehypothetical protein3e-34143
NC_021182:2422226:244371924437192443976258Clostridium pasteurianum BC1, complete genomehypothetical protein4e-33139
NC_014328:1307490:131639313163931316644252Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein3e-30130
NC_009495:2685646:269953126995312699782252Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-26118
NC_009699:2733529:274749527474952747746252Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-26118
NC_014377:1298806:131122213112221311482261Thermosediminibacter oceani DSM 16646 chromosome, complete genomeprotein of unknown function DUF9655e-2096.3
NC_010184:4219257:422873342287334228999267Bacillus weihenstephanensis KBAB4, complete genomeprotein of unknown function DUF9655e-1992.8
NC_011772:4321117:433029343302934330559267Bacillus cereus G9842, complete genomehypothetical protein5e-1992.8
NC_018870:1695588:169887716988771699191315Thermacetogenium phaeum DSM 12270 chromosome, complete genomehypothetical protein DUF9656e-1992.8
NC_005957:4169610:418145941814594181725267Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein8e-1992.4
NC_014335:4113154:412399141239914124257267Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein8e-1992.4
NC_007530:4176462:419230241923024192568267Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein8e-1992.4
NC_011658:4171237:418307841830784183344267Bacillus cereus AH187 chromosome, complete genomehypothetical protein8e-1992.4
NC_017200:4191963:420362442036244203890267Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein8e-1992.4
NC_018515:989616:100353510035351003789255Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein1e-1892
NC_011969:4065460:407843840784384078815378Bacillus cereus Q1 chromosome, complete genomehypothetical protein1e-1892
NC_020272:1311932:131465313146531314919267Bacillus amyloliquefaciens IT-45, complete genomehypothetical protein5e-1786.7
NC_013895:35410:528135281353076264Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completehypothetical protein5e-1786.3
NC_020995:2636519:265023726502372650503267Enterococcus casseliflavus EC20, complete genomehypothetical protein1e-1685.5
NC_014251:440875:458300458300458566267Streptococcus pneumoniae TCH8431/19A chromosome, complete genomehypothetical protein2e-1684.3
NC_010380:254088:272100272100272366267Streptococcus pneumoniae Hungary19A-6, complete genomehypothetical protein2e-1684.3
NC_012469:198096:216088216088216354267Streptococcus pneumoniae Taiwan19F-14, complete genomehypothetical protein2e-1684.3
NC_011830:3786173:378719337871933787444252Desulfitobacterium hafniense DCB-2, complete genomeprotein of unknown function DUF9657e-1475.9
NC_014098:1114076:111898011189801119246267Bacillus tusciae DSM 2912 chromosome, complete genomeprotein of unknown function DUF9655e-1372.8