Pre_GI: BLASTP Hits

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Query: NC_008593:1461771:1470002 Clostridium novyi NT, complete genome

Start: 1470002, End: 1470262, Length: 261

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014098:1114076:111967311196731119948276Bacillus tusciae DSM 2912 chromosome, complete genomeprotein of unknown function DUF12921e-0755.1
NC_003030:1811820:183055718305571830820264Clostridium acetobutylicum ATCC 824, complete genomehypothetical protein2e-1168.2
NC_015687:1811573:183215718321571832420264Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein2e-1168.2
NC_017295:1809386:182997018299701830233264Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein2e-1168.2
NC_009495:2685646:269864326986432698897255Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-1684.7
NC_009699:2733529:274660727466072746861255Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-1684.7
NC_014328:1307490:131730013173001317560261Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein4e-1063.5
NC_021182:2422226:244468124446812444947267Clostridium pasteurianum BC1, complete genomehypothetical protein3e-1167
NC_014377:1298806:130945613094561309752297Thermosediminibacter oceani DSM 16646 chromosome, complete genomeprotein of unknown function DUF12927e-0959.3