Pre_GI: BLASTP Hits

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Query: NC_008593:1461771:1463620 Clostridium novyi NT, complete genome

Start: 1463620, End: 1464276, Length: 657

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012483:656397:671410671410672078669Acidobacterium capsulatum ATCC 51196, complete genomeO-methyltransferase1e-1066.6
NC_013093:3791912:380868138086813809337657Actinosynnema mirum DSM 43827, complete genomeCaffeoyl-CoA O-methyltransferase2e-1479
NC_013093:3068486:310343131034313103922492Actinosynnema mirum DSM 43827, complete genomeO-methyltransferase family 32e-0859.3
NC_018643:641360:659936659936660586651Alpha proteobacterium HIMB5 chromosome, complete genomeO-methyltransferase1e-1686.7
NC_020272:1311932:131699213169921317645654Bacillus amyloliquefaciens IT-45, complete genomeO-methyltransferase5e-33140
NC_007530:4176462:418946241894624190103642Bacillus anthracis str. 'Ames Ancestor', complete genomeo-methyltransferase family protein2e-29129
NC_011658:4171237:418024041802404180881642Bacillus cereus AH187 chromosome, complete genomeO-methyltransferase family protein6e-29127
NC_014335:4113154:412115141211514121792642Bacillus cereus biovar anthracis str. CI chromosome, completeO-methyltransferase family protein2e-29129
NC_011772:4321117:432744543274454328086642Bacillus cereus G9842, complete genomeO-methyltransferase family protein6e-30130
NC_011969:4065460:407560040756004076241642Bacillus cereus Q1 chromosome, complete genomeo-methyltransferase family protein6e-29127
NC_017200:4191963:420078642007864201427642Bacillus thuringiensis serovar finitimus YBT-020 chromosome,O-methyltransferase family protein2e-29129
NC_005957:4169610:417861941786194179260642Bacillus thuringiensis serovar konkukian str. 97-27, completeO-methyltransferase; possible caffeoyl-CoA O-methyltransferase2e-29129
NC_010184:4219257:422585642258564226497642Bacillus weihenstephanensis KBAB4, complete genomeO-methyltransferase family 37e-29127
NC_015164:2859000:286483828648382865476639Bacteroides salanitronis DSM 18170 chromosome, complete genomeO-methyltransferase family 39e-1477
NC_008060:1945597:196075819607581961534777Burkholderia cenocepacia AU 1054 chromosome 1, complete sequenceO-methyltransferase, family 31e-1066.6
NC_008542:2631138:264629926462992647075777Burkholderia cenocepacia HI2424 chromosome 1, complete sequenceO-methyltransferase, family 31e-1066.6
NC_014657:673500:686973686973687611639Caldicellulosiruptor owensensis OL chromosome, complete genomeo-methyltransferase family 32e-37155
NC_019791:570923:591632591632592492861Caldisphaera lagunensis DSM 15908 chromosome, complete genomemethyltransferase1e-0757
NC_010830:718614:728896728896729543648Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein7e-1684
NC_015722:209722:212869212869213519651Candidatus Midichloria mitochondrii IricVA chromosome, completeo-methyltransferase family protein9e-1787
NC_009495:2685646:269199426919942692650657Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeO-methyltransferase1e-81301
NC_009699:2733529:273995627399562740612657Clostridium botulinum F str. Langeland chromosome, complete genomeO-methyltransferase family protein2e-81301
NC_014328:1307490:132241013224101323057648Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative O-methyltransferase1e-78292
NC_004557:749330:7605677605677617811215Clostridium tetani E88, complete genomeprecorrin-6B methylase/decarboxylase cbiT/cbiE1e-0653.5
NC_006958:179690:187688187688188104417Corynebacterium glutamicum ATCC 13032, complete genomeO-METHYL TRANSFERASE (N-terminal FRAGMENT)7e-0960.5
NC_003450:179689:187687187687188103417Corynebacterium glutamicum ATCC 13032, complete genomeSAM-dependent methyltransferase7e-0960.5
NC_013939:492959:502977502977503603627Deferribacter desulfuricans SSM1, complete genomecaffeoyl-CoA O-methyltransferase7e-1890.5
NC_013943:2431643:243959424395942440199606Denitrovibrio acetiphilus DSM 12809 chromosome, complete genomeO-methyltransferase family protein4e-1375.1
NC_011830:4645453:466165246616524662338687Desulfitobacterium hafniense DCB-2, complete genomeO-methyltransferase family 34e-33141
NC_014624:3463272:348444934844493485099651Eubacterium limosum KIST612 chromosome, complete genomeO-methyltransferase family protein1e-57223
NC_008245:1845525:185325518532551853911657Francisella tularensis subsp. tularensis FSC 198, complete genomeO-methyltransferase6e-0960.8
NC_016937:1850382:185332518533251853981657Francisella tularensis subsp. tularensis TI0902 chromosome,O-methyltransferase family protein (C1)6e-0960.8
NC_009257:5615:186941869419350657Francisella tularensis subsp. tularensis WY96-3418 chromosome,O-methyltransferase family protein6e-0960.8
NC_014206:2971304:298734929873492988044696Geobacillus sp. C56-T3 chromosome, complete genomeO-methyltransferase family 32e-1789.4
NC_016593:2447938:247065924706592471294636Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completeO-methyltransferase1e-1996.3
NC_019978:2036779:205706120570612057708648Halobacteroides halobius DSM 5150, complete genomeputative O-methyltransferase2e-45182
NC_013202:2042776:206569220656922066357666Halomicrobium mukohataei DSM 12286, complete genomeO-methyltransferase family 33e-1995.1
NC_015496:2155816:216064721606472161288642Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomeO-methyltransferase family 31e-1376.3
NC_015276:2769000:276900527690052769631627Marinomonas mediterranea MMB-1 chromosome, complete genomeCaffeoyl-CoA O-methyltransferase5e-1064.3
NC_020126:8512908:851564385156438516284642Myxococcus stipitatus DSM 14675, complete genomeO-methyltransferase2e-1479
NC_014752:1363562:136935713693571370025669Neisseria lactamica ST-640, complete genomemethyltransferase3e-1065.1
NC_008767:1363288:136933913693391370007669Neisseria meningitidis FAM18, complete genomeputative methyltransferase4e-0961.2
NC_014840:205723:238316238316238993678Pantoea sp. At-9b plasmid pPAT9B03, complete sequenceO-methyltransferase family 32e-1582.8
NC_009615:3993187:399707039970703997705636Parabacteroides distasonis ATCC 8503 chromosome, complete genomeO-methyltransferase1e-1583.2
NC_014664:1669642:168931316893131689987675Rhodomicrobium vannielii ATCC 17100 chromosome, complete genomeO-methyltransferase family 31e-1480.1
NC_015966:2875140:288730628873062887968663Rhodothermus marinus SG0.5JP17-172 chromosome, complete genomeCaffeoyl-CoA O-methyltransferase2e-1168.9
NC_014623:9089998:909213290921329092752621Stigmatella aurantiaca DW4/3-1 chromosome, complete genomeo-methyltransferase family protein4e-1064.7
NC_007181:333891:339522339522340100579Sulfolobus acidocaldarius DSM 639, complete genomecobalt-precorrin-6Y C(15)-methyltransferase7e-1064.3
NC_013769:87582:965479654797146600Sulfolobus islandicus L.D.8.5 chromosome, complete genomeprecorrin-6Y C5,15-methyltransferase subunit CbiT2e-1169.3
NC_012589:87592:965439654397142600Sulfolobus islandicus L.S.2.15, complete genomeprecorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit2e-1169.3
NC_012588:87592:965439654397142600Sulfolobus islandicus M.14.25 chromosome, complete genomecobalt-precorrin-6Y C(15)-methyltransferase2e-1169.3
NC_012632:87590:965419654197140600Sulfolobus islandicus M.16.27 chromosome, complete genomecobalt-precorrin-6Y C(15)-methyltransferase2e-1169.3
NC_017276:85380:963909639096989600Sulfolobus islandicus REY15A chromosome, complete genomeprecorrin-6Y C5,15-methyltransferase(decarboxylating), CbiT subunit2e-1169.3
NC_003106:1809137:183387218338721834450579Sulfolobus tokodaii str. 7, complete genomecobalt-precorrin-6Y C(15)-methyltransferase1e-0653.5
NC_014831:2082304:210729921072992107949651Thermaerobacter marianensis DSM 12885 chromosome, complete genomeO-methyltransferase family 32e-1376.3
NC_007333:1129826:113348911334891134148660Thermobifida fusca YX, complete genomecaffeoyl-CoA O-methyltransferase1e-0963.2