Pre_GI: BLASTP Hits

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Query: NC_008593:1362218:1381999 Clostridium novyi NT, complete genome

Start: 1381999, End: 1383462, Length: 1464

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:1295261:1311015131101513124691455Clostridium botulinum BKT015925 chromosome, complete genomephage portal protein, SPP1 Gp6-like protein0871
NC_004668:295417:3089483089483104801533Enterococcus faecalis V583, complete genomeportal protein1e-132473
NC_014551:576000:5975255975255989761452Bacillus amyloliquefaciens DSM 7, complete genomephage portal protein, SPP1 family2e-51204
NC_017179:1683199:1705536170553617069781443Clostridium difficile BI1, complete genomephage portal protein2e-44180
NC_012658:1810640:1829468182946818309191452Clostridium botulinum Ba4 str. 657 chromosome, complete genomephage portal protein, SPP1 family7e-44178
NC_009089:1093832:1114550111455011159891440Clostridium difficile 630, complete genomephage portal protein2e-43177
NC_017297:2531750:2549469254946925509201452Clostridium botulinum F str. 230613 chromosome, complete genomephage portal protein, SPP1 family3e-43176
NC_020134:420500:4338074338074352401434Clostridium stercorarium subsp. stercorarium DSM 8532, completeportal protein3e-38159
NC_009012:2927793:2946915294691529483481434Clostridium thermocellum ATCC 27405, complete genomephage portal protein, SPP1 family4e-38159
NC_007168:2349894:2376770237677023781131344Staphylococcus haemolyticus JCSC1435, complete genomehypothetical protein2e-35150
NC_015519:1081539:1097522109752210989641443Tepidanaerobacter sp. Re1 chromosome, complete genomephage portal protein, SPP1 family2e-33144
NC_010001:3614314:3633580363358036349681389Clostridium phytofermentans ISDg, complete genomephage portal protein, SPP1 family7e-33142
NC_017341:1976000:2000857200085720022751419Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,phage portal protein, SPP1 family2e-31137
NC_009632:361229:3802933802933817711479Staphylococcus aureus subsp. aureus JH1 chromosome, completeSPP1 family phage portal protein4e-31136
NC_009487:362475:3802833802833817011419Staphylococcus aureus subsp. aureus JH9 chromosome, completeSPP1 family phage portal protein4e-31136
NC_013517:1501276:1501276150127615027271452Sebaldella termitidis ATCC 33386, complete genomeportal protein SPP12e-30134
NC_008530:646207:6585636585636599751413Lactobacillus gasseri ATCC 33323, complete genomePhage portal protein, SPP1 Gp6-like1e-28128
NC_015913:117966:1338771338771352651389Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomephage portal protein4e-28126
NC_014376:1472304:1493436149343614948421407Clostridium saccharolyticum WM1 chromosome, complete genomephage portal protein, SPP1 family9e-28125
NC_017294:115500:1332501332501345751326Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomephage portal protein, SPP1 family4e-26119
NC_017294:403422:4109454109454121561212Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomephage portal protein, SPP1 family4e-26119
NC_020272:2748733:2778964277896427803671404Bacillus amyloliquefaciens IT-45, complete genomephage Portal protein2e-1067.4
NC_006322:1415863:1442488144248814439031416Bacillus licheniformis ATCC 14580, complete genomehypothetical protein3e-0963.5
NC_006270:1415001:1441626144162614430411416Bacillus licheniformis ATCC 14580, complete genomephage related protein3e-0963.5
NC_014925:578759:6016256016256030701446Staphylococcus pseudintermedius HKU10-03 chromosome, completePhage portal protein2e-0757.4
NC_017188:2221705:2224665222466522260981434Bacillus amyloliquefaciens TA208 chromosome, complete genomehypothetical protein8e-0755.8
NC_009487:921884:9385699385699401071539Staphylococcus aureus subsp. aureus JH9 chromosome, completeSPP1 family phage portal protein9e-0755.5
NC_009632:921759:9384449384449399821539Staphylococcus aureus subsp. aureus JH1 chromosome, completeSPP1 family phage portal protein9e-0755.5
NC_017191:2223740:2226700222670022280761377Bacillus amyloliquefaciens XH7 chromosome, complete genomephage-like protein9e-0755.5
NC_009782:920272:9366709366709382051536Staphylococcus aureus subsp. aureus Mu3, complete genomehypothetical protein9e-0755.5
NC_002758:918827:9352269352269367611536Staphylococcus aureus subsp. aureus Mu50, complete genomehypothetical protein9e-0755.5
NC_007622:1842000:1867976186797618695171542Staphylococcus aureus RF122, complete genomehypothetical phage-related protein1e-0655.1
NC_017351:643674:6616886616886632261539Staphylococcus aureus subsp. aureus 11819-97 chromosome, completephage portal protein, SPP1 family2e-0654.7
NC_009641:1979053:2003389200338920049241536Staphylococcus aureus subsp. aureus str. Newman chromosome,phage portal protein2e-0654.3
NC_009641:1105075:1117204111720411187391536Staphylococcus aureus subsp. aureus str. Newman chromosome,phage portal protein2e-0654.3
NC_007795:1922000:1947236194723619487711536Staphylococcus aureus subsp. aureus NCTC 8325, complete genomephage portal protein, SPP1 family3e-0653.5
NC_009674:2985878:3005254300525430066091356Bacillus cytotoxicus NVH 391-98 chromosome, complete genomeSPP1 family phage portal protein5e-0653.1