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Query: NC_008593:1362218:1380741 Clostridium novyi NT, complete genome

Start: 1380741, End: 1382012, Length: 1272

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:1295261:1312456131245613137271272Clostridium botulinum BKT015925 chromosome, complete genomeminor head protein0785
NC_004668:295417:3104103104103118731464Enterococcus faecalis V583, complete genomeminor head protein3e-55216
NC_009641:327325:341183341183342136954Staphylococcus aureus subsp. aureus str. Newman chromosome,hypothetical protein5e-31135
NC_017341:1976000:199993819999382000900963Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,phage minor head protein2e-29130
NC_009632:361229:381728381728382690963Staphylococcus aureus subsp. aureus JH1 chromosome, completeSPP1 family phage head morphogenesis protein7e-29128
NC_009487:362475:381658381658382620963Staphylococcus aureus subsp. aureus JH9 chromosome, completeSPP1 family phage head morphogenesis protein7e-29128
NC_007168:2349894:237586923758692376825957Staphylococcus haemolyticus JCSC1435, complete genomehypothetical protein1e-28127
NC_014551:576000:598963598963599886924Bacillus amyloliquefaciens DSM 7, complete genomeMinor head structural component GP75e-22105
NC_020272:2748733:277805127780512778977927Bacillus amyloliquefaciens IT-45, complete genomeMinor head structural component GP79e-21101
NC_006270:1415001:144302514430251443942918Bacillus licheniformis ATCC 14580, complete genomephage related minor head protein1e-1791.3
NC_006322:1415863:144388714438871444804918Bacillus licheniformis ATCC 14580, complete genomehypothetical protein1e-1791.3
NC_014377:1227850:124857012485701249451882Thermosediminibacter oceani DSM 16646 chromosome, complete genomephage head morphogenesis protein, SPP1 gp7 family1e-1585.1
NC_009706:2023912:2032684203268420340151332Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein6e-1582.4
NC_009089:1093832:1115979111597911174721494Clostridium difficile 630, complete genomeputative phage minor head protein3e-1480.1
NC_017179:1683199:1706968170696817085031536Clostridium difficile BI1, complete genomephage protein2e-1377.4
NC_009089:1093832:10873831087383114439857016Clostridium difficile 630, complete genome3e-1376.6
NC_013171:896802:916388916388917173786Anaerococcus prevotii DSM 20548, complete genomeputative head morphogenesis protein SPP1 gp71e-1274.7
NC_020134:420500:4352584352584365891332Clostridium stercorarium subsp. stercorarium DSM 8532, completephage head morphogenesis protein, SPP1 gp7 family1e-1274.7
NC_009012:2927793:2948505294850529499141410Clostridium thermocellum ATCC 27405, complete genomephage putative head morphogenesis protein, SPP1 gp7 family5e-1169.3
NC_014376:1472304:1494842149484214964161575Clostridium saccharolyticum WM1 chromosome, complete genomephage head morphogenesis protein, SPP1 gp7 family2e-0964.3
NC_015519:1081539:1098996109899611005371542Tepidanaerobacter sp. Re1 chromosome, complete genomephage head morphogenesis protein, SPP1 gp7 family2e-0860.5
NC_016077:1278104:1280922128092212824091488Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein7e-0858.9
NC_017297:2531750:2548457254845725494791023Clostridium botulinum F str. 230613 chromosome, complete genomephage head morphogenesis protein6e-0858.9
NC_000964:2670288:268508226850822685999918Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein8e-0858.5
NC_013891:1639694:164959016495901650354765Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomephage minor head protein, putative3e-0653.5
NC_012658:1810640:1830909183090918319311023Clostridium botulinum Ba4 str. 657 chromosome, complete genomephage head morphogenesis protein, SPP1 gp7 family4e-0653.1
NC_017191:2223740:222374022237402224609870Bacillus amyloliquefaciens XH7 chromosome, complete genomeminor head structural component GP74e-0652.8
NC_017188:2221705:222170522217052222574870Bacillus amyloliquefaciens TA208 chromosome, complete genomehypothetical protein4e-0652.8