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Query: NC_008593:1362218:1378344 Clostridium novyi NT, complete genome

Start: 1378344, End: 1379036, Length: 693

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:1295261:131472713147271315563837Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein3e-114410
NC_014377:1227850:124693612469361247766831Thermosediminibacter oceani DSM 16646 chromosome, complete genomehypothetical protein9e-55213
NC_016641:2587000:261308826130882613918831Paenibacillus terrae HPL-003 chromosome, complete genomehypothetical protein7e-54210
NC_014657:914071:924267924267925100834Caldicellulosiruptor owensensis OL chromosome, complete genomehypothetical protein3e-50198
NC_017191:2223740:222483822248382225698861Bacillus amyloliquefaciens XH7 chromosome, complete genomehypothetical protein3e-50198
NC_017188:2221705:222280322228032223663861Bacillus amyloliquefaciens TA208 chromosome, complete genomehypothetical protein3e-50198
NC_016077:1278104:127855612785561279422867Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein9e-44176
NC_015416:1679188:168935916893591690246888Methanosaeta concilii GP-6 chromosome, complete genomehypothetical protein5e-42171
NC_012590:2117027:212524221252422126144903Corynebacterium aurimucosum ATCC 700975, complete genomehypothetical protein9e-24110
NC_012590:2176948:217694821769482177856909Corynebacterium aurimucosum ATCC 700975, complete genomehypothetical protein2e-21102
NC_015859:952500:987831987831988733903Corynebacterium variabile DSM 44702 chromosome, complete genomehypothetical protein3e-1891.7
NC_010397:1751067:179035717903571791187831Mycobacterium abscessus chromosome Chromosome, complete sequenceBacteriophage protein4e-1478.2
NC_016043:428476:442963442963443832870Taylorella asinigenitalis MCE3 chromosome, complete genomecapsid phage protein2e-1272.8
NC_016109:7445603:745616774561677457081915Kitasatospora setae KM-6054, complete genomehypothetical protein5e-0857.8