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Query: NC_008593:1362218:1377024 Clostridium novyi NT, complete genome

Start: 1377024, End: 1377422, Length: 399

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:1295261:131648513164851316925441Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein7e-55211
NC_006322:1415863:144909914490991449503405Bacillus licheniformis ATCC 14580, complete genomehypothetical protein2e-1787.8
NC_006270:1415001:144829114482911448641351Bacillus licheniformis ATCC 14580, complete genomephage related protein2e-1787.4
NC_020272:2748733:277478327747832775199417Bacillus amyloliquefaciens IT-45, complete genomehypothetical protein5e-1269.7
NC_007168:2349894:237298923729892373402414Staphylococcus haemolyticus JCSC1435, complete genomehypothetical protein3e-1167.4
NC_013891:1639694:164698816469881647398411Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomephage-related protein, putative5e-1166.6
NC_009641:327325:344771344771345220450Staphylococcus aureus subsp. aureus str. Newman chromosome,hypothetical protein1e-1065.1
NC_020054:4933725:493737649373764937795420Fibrella aestuarina BUZ 2 drat genomephage protein, HK97 GP10 family2e-0754.3
NC_017341:1976000:199701419970141997427414Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,phage protein2e-0754.3
NC_021182:1911088:193337119333711933853483Clostridium pasteurianum BC1, complete genomeBacteriophage protein of unknown function (DUF646)2e-0754.3
NC_009632:361229:385201385201385614414Staphylococcus aureus subsp. aureus JH1 chromosome, completeHK97 family phage protein4e-0753.5
NC_009487:362475:385131385131385544414Staphylococcus aureus subsp. aureus JH9 chromosome, completeHK97 family phage protein4e-0753.5