Pre_GI: BLASTP Hits

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Query: NC_008593:1362218:1371778 Clostridium novyi NT, complete genome

Start: 1371778, End: 1372461, Length: 684

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:1295261:132121613212161321896681Clostridium botulinum BKT015925 chromosome, complete genomephage-like protein1e-106385
NC_010520:2101515:211484421148442115521678Clostridium botulinum A3 str. Loch Maree, complete genomeputative phage tail protein3e-34145
NC_020291:1122282:113714911371491137850702Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephage-rlike protein6e-28124
NC_011773:549500:557944557944558621678Bacillus cereus AH820 chromosome, complete genomeGp13 protein4e-22104
NC_020291:795500:824893824893825561669Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephage putative tail component8e-22103
NC_008261:1787345:179485417948541795564711Clostridium perfringens ATCC 13124, complete genomeputative phage tail component2e-21102
NC_010674:950276:965214965214965930717Clostridium botulinum B str. Eklund 17B, complete genomeprophage pi2 protein 436e-1994.4
NC_010723:2269372:227265022726502273324675Clostridium botulinum E3 str. Alaska E43, complete genomeputative phage tail component6e-1890.9
NC_003212:2592600:259472325947232595463741Listeria innocua Clip11262, complete genomehypothetical protein1e-1686.7
NC_010674:2328307:233610623361062336783678Clostridium botulinum B str. Eklund 17B, complete genomeputative phage tail component1e-1583.2
NC_014246:1402500:143099214309921431678687Mobiluncus curtisii ATCC 43063 chromosome, complete genomehypothetical protein2e-1479.3
NC_008555:1204000:123664712366471237387741Listeria welshimeri serovar 6b str. SLCC5334, complete genomeconserved phage-related protein3e-1478.6
NC_012471:781063:813226813226813933708Streptococcus equi subsp. equi 4047, complete genomephage protein7e-1477.4
NC_014218:1663486:167891516789151679607693Arcanobacterium haemolyticum DSM 20595 chromosome, complete genomehypothetical protein6e-1374.3
NC_021182:3525523:356016335601633560600438Clostridium pasteurianum BC1, complete genome1e-1169.7
NC_009332:1269000:127924312792431279950708Streptococcus pyogenes str. Manfredo chromosome, complete genomehypothetical protein2e-1169.3
NC_008024:572916:579195579195579902708Streptococcus pyogenes MGAS10750, complete genomephage protein2e-1169.3
NC_008022:556457:562018562018562725708Streptococcus pyogenes MGAS10270, complete genomephage protein2e-1169.3
NC_008021:531730:560741560741561448708Streptococcus pyogenes MGAS9429, complete genomephage protein2e-1169.3
NC_006086:987991:9996179996171000324708Streptococcus pyogenes MGAS10394, complete genomeunknown phage protein2e-0962.8
NC_006086:1329915:134208413420841342800717Streptococcus pyogenes MGAS10394, complete genomeunknown phage protein7e-0960.8
NC_003485:1450045:146247114624711463187717Streptococcus pyogenes MGAS8232, complete genomehypothetical protein7e-0960.8
NC_002737:533291:559855559855560571717Streptococcus pyogenes M1 GAS, complete genomehypothetical protein6e-0960.8
NC_004606:623853:653777653777654493717Streptococcus pyogenes SSI-1, complete genomehypothetical protein8e-0960.5
NC_008022:1255210:126680312668031267519717Streptococcus pyogenes MGAS10270, complete genomephage protein8e-0960.5
NC_007296:1230614:123970512397051240421717Streptococcus pyogenes MGAS6180, complete genomephage protein8e-0960.5
NC_004070:1231883:124239212423921243108717Streptococcus pyogenes MGAS315, complete genomehypothetical protein8e-0960.5
NC_004606:904323:908291908291908953663Streptococcus pyogenes SSI-1, complete genomehypothetical protein1e-0860.1
NC_003485:602640:608575608575609318744Streptococcus pyogenes MGAS8232, complete genomehypothetical protein7e-0754.3