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Query: NC_008262:1950205 Clostridium perfringens SM101, complete genome

Start: 1950205, End: 1969678, Length: 19474

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_003366:2057656*2057656208209924444Clostridium perfringens str. 13, complete genome08655BLASTN svgBLASTP svg
NC_008593:1461771*1461771148498223212Clostridium novyi NT, complete genome2e-62248BLASTN svgBLASTP svg
NC_021182:2422226*2422226244735325128Clostridium pasteurianum BC1, complete genome1e-57232BLASTN svgBLASTP svg
NC_010516:2511035*2511035254588934855Clostridium botulinum B1 str. Okra, complete genome8e-31143BLASTN svgBLASTP svg
NC_012563:2680246*2680246272077540530Clostridium botulinum A2 str. Kyoto, complete genome8e-28133BLASTN svgBLASTP svg
NC_014328:1307490*1307490133121623727Clostridium ljungdahlii ATCC 49587 chromosome, complete genome3e-24121BLASTN svgBLASTP svg
NC_014964:11699251169925118860418680Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, complete1e-23119BLASTN svgBLASTP svg
NC_014538:1311500*1311500133539723898Thermoanaerobacter sp. X513 chromosome, complete genome1e-23119BLASTN svgBLASTP svg
NC_019978:12440001244000126570721708Halobacteroides halobius DSM 5150, complete genome2e-19105BLASTN svgBLASTP svg
NC_010520:2585014*2585014262041935406Clostridium botulinum A3 str. Loch Maree, complete genome2e-19105BLASTN svgBLASTP svg
NC_010674:24352412435241245936424124Clostridium botulinum B str. Eklund 17B, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_015949:1180755*1180755121693036176Caldicellulosiruptor lactoaceticus 6A chromosome, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_014721:1777644*1777644181600538362Caldicellulosiruptor kristjanssonii 177R1B chromosome, complete6e-1383.8BLASTN svgBLASTP svg
NC_012034:1783912*1783912182367039759Anaerocellum thermophilum DSM 6725, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_014392:969498*969498100915039653Caldicellulosiruptor obsidiansis OB47 chromosome, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_014720:1161841*1161841118148419644Caldicellulosiruptor kronotskyensis 2002 chromosome, complete4e-1177.8BLASTN svgBLASTP svg
NC_014652:1032711*1032711107395141241Caldicellulosiruptor hydrothermalis 108 chromosome, complete2e-0971.9BLASTN svgBLASTP svg
NC_014657:1518721*1518721154034821628Caldicellulosiruptor owensensis OL chromosome, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_015682:205900*20590025109945200Thermodesulfobacterium sp. OPB45 chromosome, complete genome9e-0660BLASTN svgBLASTP svg
NC_012563:22030372203037222476521729Clostridium botulinum A2 str. Kyoto, complete genome9e-0660BLASTN svgBLASTP svg
NC_010516:20640272064027208498120955Clostridium botulinum B1 str. Okra, complete genome9e-0660BLASTN svgBLASTP svg